<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-03-31 19:24:17 UTC</creation_date>
  <update_date>2026-08-22 01:50:46 UTC</update_date>
  <accession/>
  <common_name>2,2'-Methylenebis(4-methyl-6-tert-butylphenol)</common_name>
  <class>SmallMolecule</class>
  <description>2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is an organic compound with the formula C23H32O2 and an average molecular weight of 340.51 g/mol. 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds.

The compound is found in or released from 35 recorded sources. Within electrical and electronic equipment, these sources include antennas, coils, discharge lamps, communication cables or conductors, and conductors or conductive bodies characterised by the conductive materials. It is found in household cleaning and consumer products such as soap detergents, bleaching agents, perfumes within detergents and soaps, cigar cigarettes, and other smoking requisites. In the category of food, food processing and cookware, it is associated with food preservation, processing meats, food contact materials, and fermentation processes for beer. Additionally, it is found in drinking water and water supply, as well as building and construction materials including ladders, fencing, and ceilings. Recorded exposure routes for the compound include touch, oral, and inhalation.

Regarding plastics, 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) is used in low-density polyethylene and high-density polyethylene. It is released in polyethylene terephthalate and polypropylene, and it is present in polyvinyl chloride, polystyrene, and acrylonitrile butadiene styrene. The compound has not been detected in polycarbonate.</description>
  <categories/>
  <types/>
  <synonyms>
    <synonym>-Methylenebis(6-tert-butyl-4-methylphenol)</synonym>
    <synonym>119471</synonym>
    <synonym>1X1&amp;1&amp;R BQ E1 C1R BQ E1 CX1&amp;1&amp;1</synonym>
    <synonym>2, 2'-Bis-6-terc.butyl-p-kresylmethan</synonym>
    <synonym>2, 2'-Methylenebis[4-methyl-6-tert-butylphenol]</synonym>
    <synonym>2, 2'-Methylenebis[6-(1,1-dimethylethyl)-p-cresol]</synonym>
    <synonym>2, 2'-Methylenebis[6-tert-butyl-p-cresol]</synonym>
    <synonym>2,2'-Bis-6-terc.butyl-p-kresylmethan</synonym>
    <synonym>2,2'-Bis-6-terc.butyl-p-kresylmethan [Czech]</synonym>
    <synonym>2,2'-methanediylbis(6-tert-butyl-4-methylphenol)</synonym>
    <synonym>2,2'-methanediylbis[6-(1,1-dimethylethyl)-4-methylphenol]</synonym>
    <synonym>2,2'-Methylene-bis(6-tert-butyl-4-methylphenol)</synonym>
    <synonym>2,2'-METHYLENE-BIS-(4-METHYL-6-TERT-BUTYLPHENOL)</synonym>
    <synonym>2,2'-METHYLENEBIS(4-METHYL-6-TERT-BUTYL-PHENOL)</synonym>
    <synonym>2,2'-Methylenebis(4-methyl-6-tert-butylphenol)</synonym>
    <synonym>2,2'-Methylenebis(6-(1,1-dimethylethyl)-4-methylphenol)</synonym>
    <synonym>2,2'-Methylenebis(6-(1,1-dimethylethyl)-p-cresol)</synonym>
    <synonym>2,2'-Methylenebis(6-tert-butyl-4-methyl phenol)</synonym>
    <synonym>2,2'-Methylenebis(6-tert-butyl-4-methyl-phenol)</synonym>
    <synonym>2,2'-methylenebis(6-tert-butyl-4-methylphenol)</synonym>
    <synonym>2,2'-Methylenebis(6-tert-butyl-p-cresol)</synonym>
    <synonym>2,2'-Methylenebis(6-tert.-butyl-4-methyl phenol)</synonym>
    <synonym>2,2'-Methylenebis[4-methyl-6-(2-methyl-2-propanyl)phenol]</synonym>
    <synonym>2,2'-Methylenebis[4-Methyl-6-tert-butylphenol]</synonym>
    <synonym>2,2'-Methylenebis[6-(1,1-dimethylethyl)-p-cresol]</synonym>
    <synonym>2,2'-Methylenebis[6-tert-butyl-p-cresol]</synonym>
    <synonym>2,2-Methylene-Bis(4-Methyl-6-Tertiarybutylphenol)</synonym>
    <synonym>2,2-Methylenebis(4-methyl-6-t-butylphenol)</synonym>
    <synonym>2,2-METHYLENEBIS(6-TERT-BUTYL-4-METHYLPHENOL)</synonym>
    <synonym>2,2Ã¢â‚¬Â²</synonym>
    <synonym>2,2ÃƒÂ¢Ã‚â‚¬Ã‚Â²-methylene-bis(6-tert-butyl-4-methylphenol)</synonym>
    <synonym>2,2ÃƒÂ¢Ã‚â‚¬Ã‚Â²-Methylenebis(6-tert-butyl-4-methylphenol)</synonym>
    <synonym>2,2`-Methylenebis(4-methyl-6-tert-butylphenol)</synonym>
    <synonym>2-(tert-butyl)-6-{[3-(tert-butyl)-2-hydroxy-5-methylphenyl]methyl}-4-methylphe nol</synonym>
    <synonym>2-(tert-butyl)-6-{[3-(tert-butyl)-2-hydroxy-5-methylphenyl]methyl}-4-methylphenol</synonym>
    <synonym>2-tert-Butyl-6-(2-hydroxy-3-tert-butyl-5-methyl-benzyl)-4-methyl-phenol</synonym>
    <synonym>2-tert-butyl-6-(3-tert-butyl-2-hydroxy-5-methyl-benzyl)-4-methyl-phenol</synonym>
    <synonym>2-tert-butyl-6-[(2-hydroxyphenyl)methyl]-4-methylphenol</synonym>
    <synonym>2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methyl-phenyl)methyl]-4-methyl-phenol</synonym>
    <synonym>2-tert-Butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol</synonym>
    <synonym>6,6'-Di-tert-butyl-2,2'-methylenedi-p-cresol</synonym>
    <synonym>6,6'-Methylenebis(2-(tert-butyl)-4-methylphenol)</synonym>
    <synonym>A 22-46</synonym>
    <synonym>A-22-46</synonym>
    <synonym>Advastab 405</synonym>
    <synonym>Alterungsschutzmittel BKF</synonym>
    <synonym>Antage W 400</synonym>
    <synonym>Anti Ox</synonym>
    <synonym>Antioxidant 1</synonym>
    <synonym>Antioxidant 2246</synonym>
    <synonym>Antioxidant BKF</synonym>
    <synonym>Antioxidant NG-2246</synonym>
    <synonym>AO 1</synonym>
    <synonym>AO 1 (Antioxidant)</synonym>
    <synonym>AO 1 (VAN)</synonym>
    <synonym>AO1</synonym>
    <synonym>BIS (2-HYDROXY-3TERT-BUTYL-5-METHYLPHENYL) METHA</synonym>
    <synonym>bis(2-hydroxy-3-tert-butyl-5-methylphenyl)methane</synonym>
    <synonym>Bis(6-hydroxy-3-methyl-5-tert-butylphenyl)methane</synonym>
    <synonym>Bisaklofen BP</synonym>
    <synonym>Bisalkofen BP</synonym>
    <synonym>BKF</synonym>
    <synonym>CAO 5</synonym>
    <synonym>Catolin 14</synonym>
    <synonym>Chemanox 21</synonym>
    <synonym>Cyanox 2246</synonym>
    <synonym>Di(2-hydroxy-5-methyl-3-tert-butylphenyl)methane</synonym>
    <synonym>EINECS 204-327-1</synonym>
    <synonym>FR-0126</synonym>
    <synonym>Lederle 2246</synonym>
    <synonym>Methane, 2,2'-bis(6-t-butyl-p-cresyl)-</synonym>
    <synonym>Methane, 2,2'-bis(6-tert-butyl-p-cresyl)-</synonym>
    <synonym>Methylene bis methyl butyl phenol</synonym>
    <synonym>METHYLENE DI-T-BUTYLCRESOL</synonym>
    <synonym>MLS-0146298.0001</synonym>
    <synonym>NCGC00164172-01</synonym>
    <synonym>Nocrac NS 6</synonym>
    <synonym>Nocrack NS 6</synonym>
    <synonym>Oprea1_122036</synonym>
    <synonym>Oxy Chek 114</synonym>
    <synonym>p-Cresol, 2,2'-methylenebis(6-tert-butyl-</synonym>
    <synonym>p-Cresol, 2,2'-methylenebis(6-tert-butyl- (8CI)</synonym>
    <synonym>p-Cresol, 2,2'-methylenebis[6-tert-butyl-</synonym>
    <synonym>PA3500000</synonym>
    <synonym>Phenol, 2,2'-methylenebis(6-(1,1-dimethylethyl)-4-methyl-</synonym>
    <synonym>phenol, 2,2'-methylenebis-(4-methyl-6-t-butyl-</synonym>
    <synonym>Phenol, 2,2'-methylenebis[6-(1,1-dimethylethyl)-4-methyl-</synonym>
    <synonym>Plastanox 2246</synonym>
    <synonym>Plastanox 2246 Antioxidant</synonym>
    <synonym>Rubber Antioxidant 2246</synonym>
    <synonym>SBB007695</synonym>
    <synonym>Sumilizer MDP</synonym>
    <synonym>Synox 5LT</synonym>
    <synonym>UNII-KVM0X4X57B</synonym>
    <synonym>UNII:KVM0X4X57B</synonym>
    <synonym>Vulkanox BKF</synonym>
    <synonym>WLN: 1X1 &amp; 1 &amp; R BQ C3R BQ CX1 &amp; 1 &amp; 1</synonym>
    <synonym>[119-47-1]</synonym>
  </synonyms>
  <chemical_formula>C23H32O2</chemical_formula>
  <average_molecular_weight>340.507</average_molecular_weight>
  <monisotopic_moleculate_weight>340.24023</monisotopic_moleculate_weight>
  <iupac_name>2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol</iupac_name>
  <traditional_iupac>cyanox 2246</traditional_iupac>
  <cas_registry_number>119-47-1;107397-49-9;110736-51-1;111214-56-3;12737-12-1;129514-93-8;149984-87-2;37268-48-7;52683-48-4;537040-81-6;53807-25-3;54650-81-6;56509-58-1;59112-68-4;62339-93-9;67556-84-7;69645-40-5;90297-42-0;92880-05-2</cas_registry_number>
  <smiles>CC1=CC(CC2=CC(C)=CC(=C2O)C(C)(C)C)=C(O)C(=C1)C(C)(C)C</smiles>
  <inchi>InChI=1S/C23H32O2/c1-14-9-16(20(24)18(11-14)22(3,4)5)13-17-10-15(2)12-19(21(17)25)23(6,7)8/h9-12,24-25H,13H2,1-8H3</inchi>
  <inchikey>KGRVJHAUYBGFFP-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom>Organic compounds</kingdom>
    <super_class>Benzenoids</super_class>
    <class>Benzene and substituted derivatives</class>
    <sub_class>Diphenylmethanes</sub_class>
    <direct_parent>Diphenylmethanes</direct_parent>
    <alternate_parents>
      <alternative_parent>Hydrocarbon derivatives</alternative_parent>
      <alternative_parent>Organooxygen compounds</alternative_parent>
      <alternative_parent>Para cresols</alternative_parent>
      <alternative_parent>Phenylpropanes</alternative_parent>
      <alternative_parent>Toluenes</alternative_parent>
    </alternate_parents>
    <substituents>
      <substituent>Aromatic homomonocyclic compound</substituent>
      <substituent>Diphenylmethane</substituent>
      <substituent>Hydrocarbon derivative</substituent>
      <substituent>Organic oxygen compound</substituent>
      <substituent>Organooxygen compound</substituent>
      <substituent>P-cresol</substituent>
      <substituent>Phenol</substituent>
      <substituent>Phenylpropane</substituent>
      <substituent>Toluene</substituent>
    </substituents>
    <molecular_framework>Aromatic homomonocyclic compounds</molecular_framework>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>7.2</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>logp</kind>
      <value>5.89</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>logs</kind>
      <value>-5.55</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>solubility</kind>
      <value>9.62e-04 g/l</value>
      <source>ALOGPS</source>
    </property>
    <property>
      <kind>logp</kind>
      <value>7.57</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>pka_strongest_acidic</kind>
      <value>9.21</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>pka_strongest_basic</kind>
      <value>-5</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>iupac</kind>
      <value>2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>average_mass</kind>
      <value>340.507</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>340.24023</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CC1=CC(CC2=CC(C)=CC(=C2O)C(C)(C)C)=C(O)C(=C1)C(C)(C)C</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C23H32O2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C23H32O2/c1-14-9-16(20(24)18(11-14)22(3,4)5)13-17-10-15(2)12-19(21(17)25)23(6,7)8/h9-12,24-25H,13H2,1-8H3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>KGRVJHAUYBGFFP-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polar_surface_area</kind>
      <value>40.46</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>refractivity</kind>
      <value>107.17</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>polarizability</kind>
      <value>40.86</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>rotatable_bond_count</kind>
      <value>4</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>acceptor_count</kind>
      <value>2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>donor_count</kind>
      <value>2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>physiological_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formal_charge</kind>
      <value>0</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72a903a840&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id/>
  <hmdb_id/>
  <pubchem_compound_id>8398</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id>8092</chemspider_id>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
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  <wikipidia/>
  <general_references/>
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</compound>
