1.0 2026-03-31 21:20:03 UTC 2026-08-19 16:13:29 UTC Amifloxacin SmallMolecule Amifloxacin is an organic compound with the formula C16H19F1N4O3 and an average molecular weight of 334.35 g/mol. Amifloxacin belongs to the quinoline carboxylic acids, a subclass of quinolines and derivatives within the organic compounds. It is categorized as an organoheterocyclic compound. This compound is found in or released from healthcare, pharmaceuticals, and veterinary products used as antibiotics. Recorded exposure routes for amifloxacin include inhalation and oral administration. In terms of biological activity, the substance acts on two recorded protein targets, serving as an inhibitor of DNA topoisomerase 2-alpha (TOP2A) and DNA topoisomerase 2-beta (TOP2B). 2-(2-aminopropan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1 289-231-8 3-Quinolinecarboxylic acid, 6-fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo- 6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)- 4-oxo-3-quinolinecarboxylic acid 6-Fluoro-1,4-dihydro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 6-Fluoro-1-(methylamino)-7-(4-methyl-1-piperazinyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 6-Fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 6-fluoro-1-methylamino-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid 6-Fluoro-1-methylamino-7-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid 6-fluoro-1-methylamino-7-(4-methylpiperazin-1-yl)-4-oxo-quinoline-3-carboxylic acid 6-fluoro-1-methylamino-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 6-fluoro-4-keto-1-methylamino-7-(4-methylpiperazin-1-yl)quinoline-3-carboxylic acid 88036-80-0 (MESYLATE SALT) Amifloxacin Amifloxacin (USAN/INN) Amifloxacin [USAN:BAN:INN] Amifloxacine [French] Amifloxacino [Spanish] Amifloxacinum [Latin] EINECS 289-231-8 UNII-5TU5227KYQ UNII:5TU5227KYQ C16H19F1N4O3 334.351 334.144119 6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid amifloxacin 86393-37-5 CNN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCN(C)CC1 InChI=1S/C16H19FN4O3/c1-18-21-9-11(16(23)24)15(22)10-7-12(17)14(8-13(10)21)20-5-3-19(2)4-6-20/h7-9,18H,3-6H2,1-2H3,(H,23,24) RUXPNBWPIRDVTH-UHFFFAOYSA-N Organic compounds Phenylpropanoids and polyketides Macrolides and analogues Macrolides and analogues 1-hydroxy-2-unsubstituted benzenoids 1-hydroxy-4-unsubstituted benzenoids Carboxylic acid esters Hydrocarbon derivatives Hydroxybenzoic acid derivatives Lactones Monocarboxylic acids and derivatives Organic oxides Oxacyclic compounds Polyols Secondary alcohols Vinylogous acids 1-hydroxy-2-unsubstituted benzenoid 1-hydroxy-4-unsubstituted benzenoid Alcohol Aromatic heteropolycyclic compound Benzenoid Carboxylic acid derivative Carboxylic acid ester Dihydroxybenzoic acid Hydrocarbon derivative Lactone Macrolide Monocarboxylic acid or derivatives Organic oxide Organic oxygen compound Organoheterocyclic compound Organooxygen compound Oxacycle Polyol Secondary alcohol Vinylogous acid Aromatic heteropolycyclic compounds Mycotoxins macrolide Detected and Not Quantified logp 0.2 logp -0.95 ALOGPS logs -2.40 ALOGPS solubility 1.34e+00 g/l ALOGPS logp 0.003 ChemAxon pka_strongest_acidic 5.75 ChemAxon pka_strongest_basic 6.51 ChemAxon iupac 6-fluoro-1-(methylamino)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ChemAxon average_mass 334.351 ChemAxon mono_mass 334.144119 ChemAxon smiles CNN1C=C(C(O)=O)C(=O)C2=CC(F)=C(C=C12)N1CCN(C)CC1 ChemAxon formula C16H19F1N4O3 ChemAxon inchi InChI=1S/C16H19FN4O3/c1-18-21-9-11(16(23)24)15(22)10-7-12(17)14(8-13(10)21)20-5-3-19(2)4-6-20/h7-9,18H,3-6H2,1-2H3,(H,23,24) ChemAxon inchikey RUXPNBWPIRDVTH-UHFFFAOYSA-N ChemAxon polar_surface_area 76.12 ChemAxon refractivity 109.43 ChemAxon polarizability 33.63 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 7 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7280cffd38> DB20048 55492 50111 BE0000742 BE0002425