<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-04 18:01:41 UTC</creation_date>
  <update_date>2026-08-21 22:57:20 UTC</update_date>
  <accession/>
  <common_name>4,4'-Thiobis[2-tert-butyl-6-methylphenol]</common_name>
  <class>SmallMolecule</class>
  <description>4,4'-Thiobis[2-tert-butyl-6-methylphenol] is an organic compound with the chemical formula C22H30O2S1 and an average molecular weight of 358.54 g/mol. 4,4'-Thiobis[2-tert-butyl-6-methylphenol] belongs to the aryl thioethers, a subclass of thioethers within the organic compounds.

This substance is found in or released from 15 recorded sources. Within the category of electrical and electronic equipment, it is associated with communication cables or conductors, electrodes, fixed capacitors and their manufacture, electric switches, and conductors or conductive bodies characterised by the conductive materials, among four other sources. In the realm of food, food processing, and cookware, it is linked to food contact materials, food preservation, brew kettles, and the preparation of wort. Additionally, it is found in household cleaning and consumer products, specifically in tobacco smoke filters and cigar cigarettes. Recorded exposure routes for this compound include inhalation, oral, and touch.</description>
  <categories/>
  <types>
    <type>Phenolic Antioxidant</type>
  </types>
  <synonyms>
    <synonym>2-(tert-butyl)-4-[3-(tert-butyl)-4-hydroxy-5-methylphenylthio]-6-methylphenol</synonym>
    <synonym>2-tert-butyl-4-(3-tert-butyl-4-hydroxy-5-methyl-phenyl)sulfanyl-6-methyl-phenol</synonym>
    <synonym>2-tert-butyl-4-(3-tert-butyl-4-hydroxy-5-methylphenyl)sulfanyl-6-methylphenol</synonym>
    <synonym>2-tert-butyl-4-[(3-tert-butyl-4-hydroxy-5-methyl-phenyl)thio]-6-methyl-phenol</synonym>
    <synonym>2-tert-butyl-4-[(3-tert-butyl-4-hydroxy-5-methylphenyl)thio]-6-methylphenol</synonym>
    <synonym>3-tert-Butyl-4-hydroxy-5-methylphenyl sulfide</synonym>
    <synonym>4, 4'-Thio-bis (6-tert-butyl-o-cresol)</synonym>
    <synonym>4,4'-Sulfanediylbis(2-tert-butyl-6-methylphenol)</synonym>
    <synonym>4,4'-Sulfanediylbis[2-methyl-6-(2-methyl-2-propanyl)phenol]</synonym>
    <synonym>4,4'-Thio-bis(6-tert-butyl-o-cresol)</synonym>
    <synonym>4,4'-Thiobis(2-(1,1-dimethylethyl)-6-methylphenol)</synonym>
    <synonym>4,4'-Thiobis(2-(tert-butyl)-6-methylphenol)</synonym>
    <synonym>4,4'-thiobis(2-methyl-6-tert-butylphenol)</synonym>
    <synonym>4,4'-Thiobis(2-tert-butyl-6-methylphenol)</synonym>
    <synonym>4,4'-Thiobis(6-tert-butyl-o-cresol)</synonym>
    <synonym>4,4'-Thiobis[2-tert-butyl-6-methylphenol]</synonym>
    <synonym>4,4-THIOBIS(6-TERT-BUTYL-O-CRESOL)</synonym>
    <synonym>6,6'-di-tert-butyl-4,4'-thiodi-o-cresol</synonym>
    <synonym>Antioxidant 736</synonym>
    <synonym>Antioxidant E 736</synonym>
    <synonym>EINECS 202-522-6</synonym>
    <synonym>Ethanox 736</synonym>
    <synonym>Ethyl antioxidant 736</synonym>
    <synonym>o-Cresol, 4,4'-thiobis(6-t-butyl-</synonym>
    <synonym>o-Cresol, 4,4'-thiobis(6-tert-butyl- (8CI)</synonym>
    <synonym>o-Cresol, 4,4'-thiobis[6-tert-butyl-</synonym>
    <synonym>Oprea1_507371</synonym>
    <synonym>Oprea1_649972</synonym>
    <synonym>Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-6-met</synonym>
    <synonym>Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-6-methyl-</synonym>
    <synonym>Phenol, 4,4'-thiobis[2-(1,1-dimethylethyl)-6-methyl-</synonym>
    <synonym>ST033361</synonym>
    <synonym>TB 2</synonym>
    <synonym>Thioalkofen BM</synonym>
    <synonym>Tioalkofen BM</synonym>
    <synonym>UNII-9NZP7NUO2Y</synonym>
    <synonym>UNII:9NZP7NUO2Y</synonym>
    <synonym>WLN: 1X1&amp;1&amp;R BQ C1 ESR DQ C1 DX1&amp;1&amp;1</synonym>
    <synonym>[96-66-2]</synonym>
  </synonyms>
  <chemical_formula>C22H30O2S1</chemical_formula>
  <average_molecular_weight>358.54</average_molecular_weight>
  <monisotopic_moleculate_weight>358.196651</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>96-66-2</cas_registry_number>
  <smiles>CC1=CC(SC2=CC(=C(O)C(C)=C2)C(C)(C)C)=CC(=C1O)C(C)(C)C</smiles>
  <inchi>InChI=1S/C22H30O2S/c1-13-9-15(11-17(19(13)23)21(3,4)5)25-16-10-14(2)20(24)18(12-16)22(6,7)8/h9-12,23-24H,1-8H3</inchi>
  <inchikey>YFHKLSPMRRWLKI-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>7.4</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>358.54</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>358.196651</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CC1=CC(SC2=CC(=C(O)C(C)=C2)C(C)(C)C)=CC(=C1O)C(C)(C)C</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C22H30O2S1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C22H30O2S/c1-13-9-15(11-17(19(13)23)21(3,4)5)25-16-10-14(2)20(24)18(12-16)22(6,7)8/h9-12,23-24H,1-8H3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>YFHKLSPMRRWLKI-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7244069560&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id/>
  <hmdb_id/>
  <pubchem_compound_id>7306</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id>7033</chemspider_id>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
    <target>
      <target_id/>
      <mechanism_of_action/>
      <constants/>
      <references/>
    </target>
  </targets>
</compound>
