<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-04 18:11:38 UTC</creation_date>
  <update_date>2026-08-22 00:56:02 UTC</update_date>
  <accession/>
  <common_name>Empagliflozin</common_name>
  <class>SmallMolecule</class>
  <description>Empagliflozin is an organic compound with the formula C23H27Cl1O7 and an average molecular weight of 450.91 g/mol. Empagliflozin belongs to the carbohydrates and carbohydrate conjugates, a subclass of organooxygen compounds within the organic compounds. It is categorized as an organic oxygen compound. This substance is found in or released from healthcare, pharmaceuticals &amp; veterinary products, specifically among blood glucose lowering drugs excluding insulins, and is administered via the oral exposure route.

At the molecular level, the compound acts as an inhibitor of the protein target Sodium/glucose cotransporter 2 (SLC5A2). Empagliflozin is used in the treatment of neutropenia (PMC10074227). Additionally, it has been noted for its therapeutic effects on heart failure (PMC13084601), blood pressure (PMC11490188), and arrhythmia (PMC11490188).</description>
  <categories/>
  <types/>
  <synonyms>
    <synonym>(2S,3R,4R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol</synonym>
    <synonym>1,5-Anhydro-1-{4-chloro-3-[4-(tetrahydro-3-furanyloxy)benzyl]phenyl}hexitol</synonym>
    <synonym>Empagliflozin (BI 10773)</synonym>
    <synonym>Hexitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[(tetrahydro-3-furanyl)oxy]phenyl]methyl]phenyl]-</synonym>
  </synonyms>
  <chemical_formula>C23H27Cl1O7</chemical_formula>
  <average_molecular_weight>450.91</average_molecular_weight>
  <monisotopic_moleculate_weight>450.144531</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>864070-44-0</cas_registry_number>
  <smiles>OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=CC=C(Cl)C(CC2=CC=C(O[C@H]3CCOC3)C=C2)=C1</smiles>
  <inchi>InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2</inchi>
  <inchikey>OBWASQILIWPZMG-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Empagliflozin Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144262</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>1.66</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>450.91</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>450.144531</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=CC=C(Cl)C(CC2=CC=C(O[C@H]3CCOC3)C=C2)=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C23H27Cl1O7</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C23H27ClO7/c24-18-6-3-14(23-22(28)21(27)20(26)19(11-25)31-23)10-15(18)9-13-1-4-16(5-2-13)30-17-7-8-29-12-17/h1-6,10,17,19-23,25-28H,7-9,11-12H2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>OBWASQILIWPZMG-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf0cf9260&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB09038</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>11949646</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id>10123957</chemspider_id>
  <kegg_id/>
  <uniprot_id/>
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  <chebi_id/>
  <biocyc_id/>
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  <wikipidia/>
  <general_references/>
  <targets>
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      <target_id>BE0004753</target_id>
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</compound>
