1.0 2026-04-04 18:13:36 UTC 2026-08-18 22:06:59 UTC Teriflunomide SmallMolecule Teriflunomide is an organic compound with the formula C12H9F3N2O2 and an average molecular weight of 270.21 g/mol. Teriflunomide belongs to the trifluoromethylbenzenes, a subclass of benzene and substituted derivatives within the organic compounds. The substance is found in or released from two recorded sources: household cleaning and consumer products, specifically tobacco pipes, and healthcare, pharmaceuticals, and veterinary products, specifically immunosuppressants. The recorded exposure route for this compound is oral. Teriflunomide acts on three recorded protein targets, serving as an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH). 2-Butenamide, 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]- 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide A77 1726 A77 1726-D4 Leflunomide-d4 Metabolite (Teriflunomide-d4) C12H9F3N2O2 270.211 270.061612 163451-81-8 CC(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19) UTNUDOFZCWSZMS-UHFFFAOYSA-N Detected and Not Quantified Teriflunomide Drug Metabolism Action Pathway SMP0144197 logp 2.14 average_mass 270.211 ChemAxon mono_mass 270.061612 ChemAxon smiles CC(O)=C(/C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F ChemAxon formula C12H9F3N2O2 ChemAxon inchi InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19) ChemAxon inchikey UTNUDOFZCWSZMS-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bae6ddfd0> DB08880 54684141 16737143 BE0000382 BE0000574 BE0000612