1.0 2026-04-04 20:51:04 UTC 2026-08-21 22:38:01 UTC Clocortolone SmallMolecule Clocortolone is an organic compound with the formula C22H28ClFO4 and an average molecular weight of 410.91 g/mol. Clocortolone belongs to the hydroxysteroids, a subclass of steroids and steroid derivatives within the organic compounds. This substance is identified as an agonist/inducer of the glucocorticoid receptor (NR3C1) and targets phospholipase A2 (PLA2G1B). The compound is found in or released from three recorded sources, including corticosteroids within healthcare, pharmaceuticals, and veterinary products, as well as other smoking requisites and non-electric simulated smoking devices within household cleaning and consumer products. The recorded route of exposure for clocortolone is topical. C22H28ClFO4 410.907 410.1660153 4828-27-7 [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C InChI=1/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3 YMTMADLUXIRMGX-RFPWEZLHSA-N Detected and Not Quantified Clocortolone Action Pathway SMP0126193 Clocortolone Drug Metabolism Action Pathway SMP0143275 logp 2.47 average_mass 410.907 ChemAxon mono_mass 410.1660153 ChemAxon smiles [H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C ChemAxon formula C22H28ClFO4 ChemAxon inchi InChI=1/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3 ChemAxon inchikey YMTMADLUXIRMGX-RFPWEZLHSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7225dc25a0> DB00838 5311052 BE0000794 BE0003997