<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-05 10:43:44 UTC</creation_date>
  <update_date>2026-08-22 00:06:10 UTC</update_date>
  <accession/>
  <common_name>Suvorexant</common_name>
  <class>SmallMolecule</class>
  <description>Suvorexant is an organic compound with the formula C23H23ClN6O2 and an average molecular weight of 450.93 g/mol. Suvorexant belongs to the toluenes, a subclass of benzene and substituted derivatives within the organic compounds.

This compound is recorded as a source in healthcare, pharmaceuticals, and veterinary products, specifically categorized as a hypnotic and sedative. Its recorded route of exposure is oral. In terms of biological activity, suvorexant acts on two protein targets as an antagonist of Orexin receptor type 2 (HCRTR2) and Orexin/Hypocretin receptor type 1 (HCRTR1).</description>
  <categories/>
  <types>
    <type>Human Neurotoxin</type>
  </types>
  <synonyms/>
  <chemical_formula>C23H23ClN6O2</chemical_formula>
  <average_molecular_weight>450.93</average_molecular_weight>
  <monisotopic_moleculate_weight>450.1571017</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1030377-33-3</cas_registry_number>
  <smiles>C[C@@H]1CCN(CCN1C(=O)C1=C(C=CC(C)=C1)N1N=CC=N1)C1=NC2=C(O1)C=CC(Cl)=C2</smiles>
  <inchi>InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1</inchi>
  <inchikey>JYTNQNCOQXFQPK-MRXNPFEDSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Suvorexant Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144261</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>4.04</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>450.93</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>450.1571017</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>C[C@@H]1CCN(CCN1C(=O)C1=C(C=CC(C)=C1)N1N=CC=N1)C1=NC2=C(O1)C=CC(Cl)=C2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C23H23ClN6O2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>JYTNQNCOQXFQPK-MRXNPFEDSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bafc3a1f8&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB09034</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>24965990</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
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  <chebi_id/>
  <biocyc_id/>
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  <wikipidia/>
  <general_references/>
  <targets>
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</compound>
