1.0 2026-04-05 11:09:18 UTC 2026-08-21 21:17:48 UTC Tivozanib SmallMolecule Tivozanib is an organic compound with the chemical formula C22H19ClN4O5 and an average molecular weight of 454.87 g/mol. Tivozanib belongs to the ethers, a subclass of organooxygen compounds within the organic compounds. This compound is recorded as being released from a single source: healthcare, pharmaceuticals & veterinary products, where it is categorized as an antineoplastic agent. The recorded route of exposure for this substance is oral. Tivozanib acts on nine recorded protein targets. It functions as an inhibitor of the Mast/stem cell growth factor receptor Kit (KIT), as well as Vascular endothelial growth factor receptor 1 (FLT1), Vascular endothelial growth factor receptor 2 (KDR), and Vascular endothelial growth factor receptor 3 (FLT4). Additionally, the compound targets five other proteins. C22H19ClN4O5 454.87 454.1043974 475108-18-0 COC1=C(OC)C=C2C(OC3=CC(Cl)=C(C=C3)N=C(O)N=C3NOC(C)=C3)=CC=NC2=C1 InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) SPMVMDHWKHCIDT-UHFFFAOYSA-N Detected and Not Quantified Tivozanib Action Pathway SMP0126910 Tivozanib Drug Metabolism SMP0130851 Tivozanib Drug Metabolism Action Pathway SMP0144785 logp 4.22 average_mass 454.87 ChemAxon mono_mass 454.1043974 ChemAxon smiles COC1=C(OC)C=C2C(OC3=CC(Cl)=C(C=C3)N=C(O)N=C3NOC(C)=C3)=CC=NC2=C1 ChemAxon formula C22H19ClN4O5 ChemAxon inchi InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28) ChemAxon inchikey SPMVMDHWKHCIDT-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f727b43dcb8> DB11800 9911830 BE0000029 BE0000369 BE0000023 BE0000453 BE0000205 BE0000147 BE0000852 BE0004731 BE0000915