1.0 2026-04-05 11:39:56 UTC 2026-08-21 18:14:16 UTC Lenvatinib SmallMolecule Lenvatinib is an organic compound with the formula C21H19ClN4O4 and an average molecular weight of 426.86 g/mol. Lenvatinib belongs to the quinoline carboxamides, a subclass of quinolines and derivatives within the organic compounds. It is found in or released from healthcare, pharmaceuticals & veterinary products as an antineoplastic agent, with oral recorded exposure routes. The compound acts as an inhibitor of ten recorded protein targets, including Vascular endothelial growth factor receptor 1 (FLT1), Vascular endothelial growth factor receptor 2 (KDR), Vascular endothelial growth factor receptor 3 (FLT4), Fibroblast growth factor receptor 1 (FGFR1), and six other proteins. Lenvatinib is used as a treatment for cancer (PMC13048889), specifically liver cancer (PMC11651419), thyroid cancer (PMC13048889), renal cell carcinoma (PMC13048889), and Hepatocellular carcinoma (PMC13048889). Associated health effects include hypertension (PMC11651419) and diarrhea (PMC11651419). C21H19ClN4O4 426.86 426.1094828 417716-92-8 COC1=CC2=NC=CC(OC3=CC(Cl)=C(NC(=O)NC4CC4)C=C3)=C2C=C1C(N)=O InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28) WOSKHXYHFSIKNG-UHFFFAOYSA-N Detected and Not Quantified Lenvatinib Action Pathway SMP0126908 Lenvatinib Drug Metabolism SMP0130768 Lenvatinib Drug Metabolism Action Pathway SMP0144290 logp 2.52 average_mass 426.86 ChemAxon mono_mass 426.1094828 ChemAxon smiles COC1=CC2=NC=CC(OC3=CC(Cl)=C(NC(=O)NC4CC4)C=C3)=C2C=C1C(N)=O ChemAxon formula C21H19ClN4O4 ChemAxon inchi InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28) ChemAxon inchikey WOSKHXYHFSIKNG-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726f964b08> DB09078 9823820 BE0000029 BE0000369 BE0000023 BE0002131 BE0000748 BE0002133 BE0001203 BE0000852 BE0002411 BE0000453