1.0 2026-04-05 11:40:09 UTC 2026-08-22 05:02:49 UTC Rolapitant SmallMolecule Rolapitant is an organic compound with the formula C25H26F6N2O2. Rolapitant belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. With an average molecular weight of 500.49 g/mol, Rolapitant is a heavy molecule. It acts as an antagonist of the Substance-P receptor (TACR1). Used in healthcare, pharmaceuticals, and veterinary products as an antiemetic and antinauseant, the compound is administered via oral or intravenous exposure routes. C25H26F6N2O2 500.485 500.1898474 552292-08-7 C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1 FIVSJYGQAIEMOC-ZGNKEGEESA-N Detected and Not Quantified Rolapitant Drug Metabolism Action Pathway SMP0144404 logp 5 average_mass 500.485 ChemAxon mono_mass 500.1898474 ChemAxon smiles C[C@@H](OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)C1=CC=CC=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F ChemAxon formula C25H26F6N2O2 ChemAxon inchi InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1 ChemAxon inchikey FIVSJYGQAIEMOC-ZGNKEGEESA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7277e99080> DB09291 10311306 BE0000384