1.0 2026-04-05 11:40:51 UTC 2026-08-19 16:41:46 UTC Tofacitinib SmallMolecule Tofacitinib is an organic compound with the formula C16H20N6O and an average molecular weight of 312.38 g/mol. Tofacitinib belongs to the n-acylpiperidines, a subclass of piperidines within the organic compounds. It is categorized as an organoheterocyclic compound. The substance is found in or released from healthcare, pharmaceuticals & veterinary products used as immunosuppressants, as well as electrical & electronic equipment specifically electric hearing aids, with oral exposure recorded. At the molecular level, this compound acts as an inhibitor for four protein targets: tyrosine-protein kinase JAK1, tyrosine-protein kinase JAK2, tyrosine-protein kinase JAK3, and non-receptor tyrosine-protein kinase TYK2. Tofacitinib is used for various health effects, demonstrating therapeutic effects on psoriasis (PMC8423598) and atopic dermatitis (PMC8423598). Additionally, it is utilized as a treatment for COVID-19 (PMC9380879). C16H20N6O 312.377 312.1698593 477600-75-2 C[C@@H]1CCN(C[C@@H]1N(C)C1=NC=NC2=C1C=CN2)C(=O)CC#N InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 UJLAWZDWDVHWOW-YPMHNXCESA-N Detected and Not Quantified Tofacitinib Drug Metabolism Action Pathway SMP0144206 Tofacitinib Predicted Metabolism Pathway SMP0174801 logp 1.24 average_mass 312.377 ChemAxon mono_mass 312.1698593 ChemAxon smiles C[C@@H]1CCN(C[C@@H]1N(C)C1=NC=NC2=C1C=CN2)C(=O)CC#N ChemAxon formula C16H20N6O ChemAxon inchi InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 ChemAxon inchikey UJLAWZDWDVHWOW-YPMHNXCESA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721f2ddf28> DB08895 9926791 BE0004146 BE0002408 BE0004145 BE0003493