<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-05 11:52:46 UTC</creation_date>
  <update_date>2026-08-20 04:22:05 UTC</update_date>
  <accession/>
  <common_name>8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid</common_name>
  <class>SmallMolecule</class>
  <description>8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid belongs to the fatty acids and conjugates, a subclass of fatty acyls within the organic compounds. This compound has the formula C19H36O5 and an average molecular weight of 344.49 g/mol. It acts as an inhibitor of the protein target ATP-citrate synthase (ACLY). 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid is found in or released from healthcare, pharmaceuticals, and veterinary products used as lipid modifying agents, with oral exposure being the recorded route.</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C19H36O5</chemical_formula>
  <average_molecular_weight>344.492</average_molecular_weight>
  <monisotopic_moleculate_weight>344.2562743</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>738606-46-7</cas_registry_number>
  <smiles>CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O</smiles>
  <inchi>InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)</inchi>
  <inchikey>HYHMLYSLQUKXKP-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Bempedoic acid Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144802</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>5.3</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>344.492</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>344.2562743</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CC(C)(CCCCCC(O)CCCCCC(C)(C)C(O)=O)C(O)=O</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C19H36O5</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>HYHMLYSLQUKXKP-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f722552c260&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB11936</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>10472693</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
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  <stitch_id/>
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  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
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</compound>
