<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-05 11:55:10 UTC</creation_date>
  <update_date>2026-08-30 11:36:42 UTC</update_date>
  <accession/>
  <common_name>Ceftaroline Fosamil</common_name>
  <class>SmallMolecule</class>
  <description>Ceftaroline Fosamil belongs to the beta lactams, a subclass of lactams within the organic compounds. With an average molecular weight of 685.68 g/mol, Ceftaroline Fosamil is a heavy molecule. It is characterized by the chemical formula C22H22N8O8PS4 and is classified within the superclass of organoheterocyclic compounds.

The compound is identified as a beta-lactam antibacterial used in healthcare, pharmaceuticals, and veterinary products. Its recorded route of exposure is intravenous. Ceftaroline Fosamil acts on seven recorded protein targets, functioning as an inhibitor of Penicillin-binding protein 1A (mrcA), Penicillin-binding protein 1B (mrcB), D-alanyl-D-alanine carboxypeptidase DacC (dacC), and Peptidoglycan D,D-transpeptidase MrdA (mrdA), in addition to three other proteins.</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C22H22N8O8PS4</chemical_formula>
  <average_molecular_weight>685.68</average_molecular_weight>
  <monisotopic_moleculate_weight>685.0181053</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>229016-73-3</cas_registry_number>
  <smiles>CCON=C(/C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3=CC=[N+](C)C=C3)=C(N2C1=O)C(O)=O)C1=NSC(NP(O)(O)=O)=N1</smiles>
  <inchi>InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/p+1/b26-13-/t14-,19-/m1/s1</inchi>
  <inchikey>ZCCUWMICIWSJIX-NQJJCJBVSA-O</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Ceftaroline fosamil Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144051</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>-3.7</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>685.68</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>685.0181053</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CCON=C(/C(=O)N[C@H]1[C@H]2SCC(SC3=NC(=CS3)C3=CC=[N+](C)C=C3)=C(N2C1=O)C(O)=O)C1=NSC(NP(O)(O)=O)=N1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C22H22N8O8PS4</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C22H21N8O8PS4/c1-3-38-26-13(16-25-21(43-28-16)27-39(35,36)37)17(31)24-14-18(32)30-15(20(33)34)12(9-40-19(14)30)42-22-23-11(8-41-22)10-4-6-29(2)7-5-10/h4-8,14,19H,3,9H2,1-2H3,(H4-,24,25,27,28,31,33,34,35,36,37)/p+1/b26-13-/t14-,19-/m1/s1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>ZCCUWMICIWSJIX-NQJJCJBVSA-O</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
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  <metabolism/>
  <toxicity/>
  <lethaldose/>
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  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bcff5e8a0&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB06590</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>9852982</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
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  <biocyc_id/>
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  <wikipidia/>
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  <targets>
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