1.0 2026-04-05 11:58:18 UTC 2026-08-21 22:31:05 UTC Halobetasol SmallMolecule Halobetasol belongs to the pregnane steroids, a subclass of steroids and steroid derivatives within the organic compounds. This compound has the chemical formula $\text{C}_{22}\text{H}_{27}\text{ClF}_2\text{O}_4$ and an average molecular weight of 428.90 g/mol. It is classified as a lipid and lipid-like molecule. The substance is found in or released from three recorded sources, including household cleaning and consumer products specifically categorized as other smoking requisites, as well as healthcare, pharmaceuticals, and veterinary products where it is used as a corticosteroid and antipsoriatic. The recorded route of exposure for this compound is topical. Halobetasol interacts with four recorded protein targets, acting as an agonist or modulator of the glucocorticoid receptor (NR3C1), the steroid hormone receptor ERR1 (ESRRA), the steroid hormone receptor ERR2 (ESRRB), and the estrogen-related receptor gamma (ESRRG). C22H27ClF2O4 428.9 428.1565935 98651-66-2 C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 LEHFPXVYPMWYQD-XHIJKXOTSA-N Detected and Not Quantified Ulobetasol Action Pathway SMP0126240 Ulobetasol Drug Metabolism Action Pathway SMP0143044 logp 2.7 average_mass 428.9 ChemAxon mono_mass 428.1565935 ChemAxon smiles C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CCl ChemAxon formula C22H27ClF2O4 ChemAxon inchi InChI=1S/C22H27ClF2O4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1 ChemAxon inchikey LEHFPXVYPMWYQD-XHIJKXOTSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72261f0780> DB00596 5311167 BE0000794 BE0003722 BE0005001 BE0002088