<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-05 11:59:37 UTC</creation_date>
  <update_date>2026-05-14 19:02:41 UTC</update_date>
  <accession/>
  <common_name>Zucapsaicin</common_name>
  <class>SmallMolecule</class>
  <description>Zucapsaicin is an organic compound with the formula C18H27NO3 and an average molecular weight of 305.42 g/mol. Zucapsaicin belongs to the methoxyphenols, a subclass of phenols within the organic compounds. It is further classified as a benzenoid.

The compound is found in or released from two recorded sources: household cleaning and consumer products, specifically non-electric simulated smoking devices, and healthcare, pharmaceuticals and veterinary products, specifically topical products for joint and muscular pain. The recorded exposure route for zucapsaicin is topical. Regarding its biological activity, zucapsaicin has one recorded protein target, acting as an agonist and activator of Transient receptor potential cation channel subfamily V member 1 (TRPV1).</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C18H27NO3</chemical_formula>
  <average_molecular_weight>305.418</average_molecular_weight>
  <monisotopic_moleculate_weight>305.1990937</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>25775-90-0</cas_registry_number>
  <smiles>COC1=C(O)C=CC(CNC(=O)CCCC\C=C/C(C)C)=C1</smiles>
  <inchi>InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6-</inchi>
  <inchikey>YKPUWZUDDOIDPM-VURMDHGXSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Zucapsaicin Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144324</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>3.75</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>305.418</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>305.1990937</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>COC1=C(O)C=CC(CNC(=O)CCCC\C=C/C(C)C)=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C18H27NO3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6-</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>YKPUWZUDDOIDPM-VURMDHGXSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf331a840&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB09120</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>1548942</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
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      <target_id>BE0001023</target_id>
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</compound>
