1.0 2026-04-05 13:34:17 UTC 2026-08-22 03:07:50 UTC Olaparib SmallMolecule Olaparib is an organic compound with the formula C24H23FN4O3 and an average molecular weight of 434.47 g/mol. Olaparib belongs to the benzodiazines, a subclass of diazanaphthalenes within the organic compounds. It is used as a biological drug (PMC7968072) and is found in healthcare, pharmaceuticals, and veterinary products as an antineoplastic agent, with oral recorded exposure routes. The compound acts as an inhibitor of several protein targets, including Poly [ADP-ribose] polymerase 1 (PARP1), Poly [ADP-ribose] polymerase 2 (PARP2), Protein mono-ADP-ribosyltransferase PARP3, and Aldo-keto reductase family 1 member C3 (AKR1C3). Olaparib is used as a treatment for cancer (PMC8839250), specifically breast cancer (PMC13319688), prostate cancer (PMC5436301), and ovarian cancer (PMC12735847, PMC12964609, PMC5436301, PMC6781350, PMC8015234). It has demonstrated therapeutic effects on breast cancer (PMC6921965), ovarian cancer (PMC5436301, PMC6921965), and pancreatic cancer (PMC8015234). The administration of the compound is associated with health effects such as anemia (PMC13319688), neutropenia (PMC13319688), thrombocytopenia (PMC13319688), and acute myeloid leukemia (PMC5436301). C24H23FN4O3 434.471 434.1754188 763113-22-0 OC1=NN=C(CC2=CC(C(=O)N3CCN(CC3)C(=O)C3CC3)=C(F)C=C2)C2=CC=CC=C12 InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30) FDLYAMZZIXQODN-UHFFFAOYSA-N Detected and Not Quantified Olaparib Drug Metabolism Action Pathway SMP0144287 Olaparib Predicted Metabolism Pathway SMP0174550 logp 1.96 average_mass 434.471 ChemAxon mono_mass 434.1754188 ChemAxon smiles OC1=NN=C(CC2=CC(C(=O)N3CCN(CC3)C(=O)C3CC3)=C(F)C=C2)C2=CC=CC=C12 ChemAxon formula C24H23FN4O3 ChemAxon inchi InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30) ChemAxon inchikey FDLYAMZZIXQODN-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7224ce8b80> DB09074 23725625 BE0001717 BE0003798 BE0004049 BE0000592