<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-05 13:48:36 UTC</creation_date>
  <update_date>2026-08-22 07:29:23 UTC</update_date>
  <accession/>
  <common_name>Eravacycline</common_name>
  <class>SmallMolecule</class>
  <description>Eravacycline belongs to the tetracyclines, a class of phenylpropanoids and polyketides within the organic compounds. With an average molecular weight of 558.56 g/mol, Eravacycline is a heavy molecule. It has the chemical formula C27H31FN4O8. This compound is found in healthcare, pharmaceuticals, and veterinary products, and is administered through intravenous exposure. In terms of its biological activity, Eravacycline acts as an inhibitor of the small ribosomal subunit protein uS4 (rpsD).</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C27H31FN4O8</chemical_formula>
  <average_molecular_weight>558.563</average_molecular_weight>
  <monisotopic_moleculate_weight>558.2125922</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1207283-85-9</cas_registry_number>
  <smiles>[H][C@@]12CC3=C(C(O)=C(NC(=O)CN4CCCC4)C=C3F)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2</smiles>
  <inchi>InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34,36-37,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1</inchi>
  <inchikey>HLFSMUUOKPBTSM-ISIOAQNYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Eravacycline Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144848</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>-3.5</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>558.563</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>558.2125922</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>[H][C@@]12CC3=C(C(O)=C(NC(=O)CN4CCCC4)C=C3F)C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C27H31FN4O8</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34,36-37,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>HLFSMUUOKPBTSM-ISIOAQNYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721f8ad2a0&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB12329</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>54726192</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id>28495485</chemspider_id>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
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  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
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