1.0 2026-04-05 13:50:50 UTC 2026-08-22 05:07:45 UTC Brexpiprazole SmallMolecule Brexpiprazole is an organic compound with the chemical formula C25H27N3O2S and an average molecular weight of 433.57 g/mol. Brexpiprazole belongs to the piperazines, a subclass of diazinanes within the organic compounds. It is categorized under the superclass of organoheterocyclic compounds. The compound is found in or released from one recorded source: healthcare, pharmaceuticals & veterinary products, specifically as an antipsychotic. The recorded exposure route for this substance is oral. Brexpiprazole interacts with twelve recorded protein targets. It acts as an antagonist or partial agonist of the D(2) dopamine receptor (DRD2), 5-hydroxytryptamine receptor 1A (HTR1A), 5-hydroxytryptamine receptor 2A (HTR2A), and the Alpha-2C adrenergic receptor (ADRA2C), in addition to eight other proteins. C25H27N3O2S 433.57 433.1823981 913611-97-9 O=C1NC2=C(C=C1)C=CC(OCCCCN1CCN(CC1)C1=C3C=CSC3=CC=C1)=C2 InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29) ZKIAIYBUSXZPLP-UHFFFAOYSA-N Detected and Not Quantified Brexpiprazole Dopamine Agonist Action Pathway SMP0126698 Brexpiprazole Serotonin Action Action Pathway SMP0126699 Brexpiprazole Drug Metabolism Action Pathway SMP0144329 Brexpiprazole Predicted Metabolism Pathway SMP0174646 logp 4.65 average_mass 433.57 ChemAxon mono_mass 433.1823981 ChemAxon smiles O=C1NC2=C(C=C1)C=CC(OCCCCN1CCN(CC1)C1=C3C=CSC3=CC=C1)=C2 ChemAxon formula C25H27N3O2S ChemAxon inchi InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29) ChemAxon inchikey ZKIAIYBUSXZPLP-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7278267810> DB09128 11978813 BE0000291 BE0000756 BE0000451 BE0000342 BE0000575 BE0000581 BE0000393 BE0000650 BE0000501 BE0000715 BE0000442 BE0000092