<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-05 14:00:37 UTC</creation_date>
  <update_date>2026-08-22 09:05:12 UTC</update_date>
  <accession/>
  <common_name>Trifarotene</common_name>
  <class>SmallMolecule</class>
  <description>Trifarotene is an organic compound with the formula C29H33NO4 and an average molecular weight of 459.59 g/mol. Trifarotene belongs to the terphenyls, a subclass of benzene and substituted derivatives within the organic compounds.

This compound is recorded as being found in or released from two sources: building and construction floors, and healthcare, pharmaceuticals and veterinary products specifically used in anti-acne preparations. The recorded route of exposure is topical. Trifarotene acts as an agonist for three protein targets: Retinoic acid receptor gamma (RARG), Retinoic acid receptor alpha (RARA), and Retinoic acid receptor beta (RARB).</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C29H33NO4</chemical_formula>
  <average_molecular_weight>459.586</average_molecular_weight>
  <monisotopic_moleculate_weight>459.2409585</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>895542-09-3</cas_registry_number>
  <smiles>CC(C)(C)C1=C(C=CC(=C1)C1=C(OCCO)C=CC(=C1)C1=CC=C(C=C1)C(O)=O)N1CCCC1</smiles>
  <inchi>InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33)</inchi>
  <inchikey>MFBCDACCJCDGBA-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Trifarotene Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0144890</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>5.15</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>459.586</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>459.2409585</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CC(C)(C)C1=C(C=CC(=C1)C1=C(OCCO)C=CC(=C1)C1=CC=C(C=C1)C(O)=O)N1CCCC1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C29H33NO4</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33)</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>MFBCDACCJCDGBA-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7267819d00&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB12808</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>11518241</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
    <target>
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</compound>
