1.0 2026-04-14 17:34:14 UTC 2026-08-22 06:05:29 UTC Trametinib SmallMolecule Trametinib belongs to the pyridopyrimidines, a class of organoheterocyclic compounds within the organic compounds. With an average molecular weight of 615.39 g/mol, Trametinib is a heavy molecule with the chemical formula C26H23FIN5O4. It is found in or released from two recorded sources: electrical and electronic equipment, specifically electric hearing aids, and healthcare, pharmaceuticals, and veterinary products, where it is categorized as an antineoplastic agent. The recorded exposure route for this compound is oral. At the molecular level, Trametinib acts on two recorded protein targets as an inhibitor of dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) and dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2). Regarding health effects, the compound is used as a treatment for melanoma (PMC13053802, PMC4554797, PMC5157796). It is also associated with rash (PMC10519171, PMC5157796), alopecia (PMC5157796), thrombosis (PMC10519171), and squamous cell carcinoma (PMC5157796). C26H23FIN5O4 615.3948 615.077875874 871700-17-3 CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1 InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) LIRYPHYGHXZJBZ-UHFFFAOYSA-N Detected and Not Quantified Trametinib Drug Metabolism Action Pathway SMP0144218 logp 3.18 average_mass 615.3948 ChemAxon mono_mass 615.077875874 ChemAxon smiles CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1 ChemAxon formula C26H23FIN5O4 ChemAxon inchi InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) ChemAxon inchikey LIRYPHYGHXZJBZ-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226457460> DB08911 11707110 BE0000870 BE0004744