1.0 2026-04-14 17:47:28 UTC 2026-08-19 06:33:18 UTC Ixazomib SmallMolecule Ixazomib is an organic compound with the formula C14H19BCl2N2O4 and an average molecular weight of 361.03 g/mol. Ixazomib belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. Functioning as a biological proteasome inhibitor (PMC10344838, PMC10351539, PMC6223128, PMC7532106, PMC8786921, PMC9387011), it acts as an inhibitor of Proteasome subunit beta type-5 (PSMB5). This compound is found in healthcare, pharmaceuticals, and veterinary products as an antineoplastic agent and is administered via the oral exposure route. Ixazomib is used in the treatment of cancer (PMC10351539), lymphoma (PMC7532106), and multiple myeloma (PMC10351539, PMC12014722, PMC4559079, PMC6223128, PMC7474576, PMC8678348, PMC8713771, PMC9387011). Use of the compound is associated with several health effects, including neutropenia (PMC4559079), thrombocytopenia (PMC10351539, PMC4559079, PMC7532106, PMC8786921), fever (PMC4559079), bleeding (PMC4559079), fatigue (PMC10351539, PMC4559079), and pain (PMC4559079). Additional associated effects include nausea (PMC10351539, PMC7532106), vomiting (PMC10351539, PMC7532106), pneumonia (PMC12014722), gastroenteritis (PMC12014722), diarrhea (PMC7598776), heart failure (PMC10351539), rash (PMC10351539), and itching (PMC10351539). C14H19BCl2N2O4 361.03 360.081492 1072833-77-2 CC(C)C[C@H](NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl)B(O)O InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 MXAYKZJJDUDWDS-LBPRGKRZSA-N Detected and Not Quantified Ixazomib Drug Metabolism Action Pathway SMP0144533 logp 2.57 average_mass 361.03 ChemAxon mono_mass 360.081492 ChemAxon smiles CC(C)C[C@H](NC(=O)CNC(=O)C1=CC(Cl)=CC=C1Cl)B(O)O ChemAxon formula C14H19BCl2N2O4 ChemAxon inchi InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1 ChemAxon inchikey MXAYKZJJDUDWDS-LBPRGKRZSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7274b8e118> DB09570 25183872 BE0002348