<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 18:14:18 UTC</creation_date>
  <update_date>2026-08-22 14:20:51 UTC</update_date>
  <accession/>
  <common_name>Sennosides</common_name>
  <class>SmallMolecule</class>
  <description>Sennosides belongs to the anthracenecarboxylic acids and derivatives, a subclass of anthracenes within the organic compounds. With an average molecular weight of 862.75 g/mol, Sennosides is a heavy molecule. It is characterized by the chemical formula C42H38O20 and is classified within the superclass of benzenoids.

The compound is identified in seven recorded sources. These include household cleaning and consumer products such as pipe accessories and non electric simulated smoking devices, as well as electrical and electronic equipment including electrodes, television systems, and electrically stimulated smoking devices. Additionally, it is found in food preservation within the category of food, food processing and cookware, and is used in healthcare, pharmaceuticals and veterinary products as drugs for constipation. The recorded route of exposure for this compound is oral.

At the molecular level, sennosides interact with two recorded protein targets. It acts as an inhibitor of Aquaporin-3 (AQP3) and Reverse transcriptase/RNaseH (pol).</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C42H38O20</chemical_formula>
  <average_molecular_weight>862.746</average_molecular_weight>
  <monisotopic_moleculate_weight>862.195643624</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>517-43-1</cas_registry_number>
  <smiles>OCC1OC(OC2=C3C(=O)C4=C(C=C(C=C4O)C(O)=O)C(C4C5=CC=CC(OC6OC(CO)C(O)C(O)C6O)=C5C(=O)C5=C4C=C(C=C5O)C(O)=O)C3=CC=C2)C(O)C(O)C1O</smiles>
  <inchi>InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)</inchi>
  <inchikey>IPQVTOJGNYVQEO-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>1.19</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>862.746</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>862.195643624</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>OCC1OC(OC2=C3C(=O)C4=C(C=C(C=C4O)C(O)=O)C(C4C5=CC=CC(OC6OC(CO)C(O)C(O)C6O)=C5C(=O)C5=C4C=C(C=C5O)C(O)=O)C3=CC=C2)C(O)C(O)C1O</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C42H38O20</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>IPQVTOJGNYVQEO-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
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  <use_source/>
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  <symptoms/>
  <treatment/>
  <drugbank_id>DB11365</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>5199</pubchem_compound_id>
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