<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 18:18:50 UTC</creation_date>
  <update_date>2026-05-14 19:11:09 UTC</update_date>
  <accession/>
  <common_name>Pitolisant</common_name>
  <class>SmallMolecule</class>
  <description>Pitolisant is an organic compound with the formula C17H26ClNO and an average molecular weight of 295.85 g/mol. Pitolisant belongs to the halobenzenes, a subclass of benzene and substituted derivatives within the organic compounds.

This compound is found in or released from healthcare, pharmaceuticals, and veterinary products, specifically categorized as unclassified nervous system drugs, and is administered via the oral exposure route. Pitolisant acts on two recorded protein targets: it serves as an antagonist and inverse agonist/blocker of the Histamine H3 receptor (HRH3), and it targets the voltage-gated inwardly rectifying potassium channel KCNH2.</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C17H26ClNO</chemical_formula>
  <average_molecular_weight>295.85</average_molecular_weight>
  <monisotopic_moleculate_weight>295.1702922</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>362665-56-3</cas_registry_number>
  <smiles>ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1</smiles>
  <inchi>InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2</inchi>
  <inchikey>NNACHAUCXXVJSP-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>4.12</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>295.85</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>295.1702922</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>ClC1=CC=C(CCCOCCCN2CCCCC2)C=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C17H26ClNO</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C17H26ClNO/c18-17-9-7-16(8-10-17)6-4-14-20-15-5-13-19-11-2-1-3-12-19/h7-10H,1-6,11-15H2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>NNACHAUCXXVJSP-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f72267ec580&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB11642</drugbank_id>
  <hmdb_id/>
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  <biocyc_id/>
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  <wikipidia/>
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  <targets>
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</compound>
