1.0 2026-04-14 18:33:34 UTC 2026-08-22 07:46:33 UTC Nirogacestat SmallMolecule Nirogacestat is an organic compound with the chemical formula $\text{C}_{27}\text{H}_{41}\text{F}_2\text{N}_5\text{O}$ and an average molecular weight of 489.66 g/mol. Nirogacestat belongs to the amino acids, peptides, and analogues, a subclass of carboxylic acids and derivatives within the organic compounds. This compound is identified as an antineoplastic agent within the category of healthcare, pharmaceuticals, and veterinary products. It is administered via the oral exposure route. In terms of its biological activity, Nirogacestat acts as an inhibitor or modulator of six recorded protein targets. These targets include Presenilin-1 (PSEN1), Presenilin-2 (PSEN2), Gamma-secretase subunit APH-1A (APH1A), and Gamma-secretase subunit PEN-2 (PSENEN), as well as two additional proteins. C27H41F2N5O 489.656 489.327917286 1290543-63-3 CCC[C@H](N[C@H]1CCC2=CC(F)=CC(F)=C2C1)C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1 VFCRKLWBYMDAED-REWPJTCUSA-N Detected and Not Quantified logp 5.5 average_mass 489.656 ChemAxon mono_mass 489.327917286 ChemAxon smiles CCC[C@H](N[C@H]1CCC2=CC(F)=CC(F)=C2C1)C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C ChemAxon formula C27H41F2N5O ChemAxon inchi InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1 ChemAxon inchikey VFCRKLWBYMDAED-REWPJTCUSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3baf239118> DB12005 46224413 BE0010960 BE0011014 BE0003409 BE0003410 BE0017533 BE0017775