1.0 2026-04-14 19:57:39 UTC 2026-08-22 02:53:53 UTC Ripretinib SmallMolecule Ripretinib is an organic compound with the chemical formula C24H21BrFN5O2. Ripretinib belongs to the phenylpyridines, a subclass of pyridines and derivatives within the organic compounds. With an average molecular weight of 510.37 g/mol, Ripretinib is a heavy molecule. Classified as an organoheterocyclic compound, this substance is found in or released from healthcare, pharmaceuticals, and veterinary products, specifically as part of the antineoplastic agents. The recorded route of exposure for this compound is oral. Ripretinib acts on six recorded protein targets, functioning as an inhibitor of the Mast/stem cell growth factor receptor Kit (KIT), the Platelet-derived growth factor receptor beta (PDGFRB), the Angiopoietin-1 receptor (TEK), and the Vascular endothelial growth factor receptor 2 (KDR), in addition to two other proteins. C24H21BrFN5O2 510.367 509.086266 1442472-39-0 CCN1C(=O)C(=CC2=C1C=C(NC)N=C2)C1=C(Br)C=C(F)C(NC(=O)NC2=CC=CC=C2)=C1 InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33) CEFJVGZHQAGLHS-UHFFFAOYSA-N Detected and Not Quantified Ripretinib Action Pathway SMP0126912 Ripretinib Drug Metabolism Action Pathway SMP0145225 Ripretinib Predicted Metabolism Pathway SMP0174724 logp 4.39 average_mass 510.367 ChemAxon mono_mass 509.086266 ChemAxon smiles CCN1C(=O)C(=CC2=C1C=C(NC)N=C2)C1=C(Br)C=C(F)C(NC(=O)NC2=CC=CC=C2)=C1 ChemAxon formula C24H21BrFN5O2 ChemAxon inchi InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33) ChemAxon inchikey CEFJVGZHQAGLHS-UHFFFAOYSA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f726df0eec0> DB14840 71584930 BE0000453 BE0000205 BE0003379 BE0000369 BE0000634 BE0000852