1.0 2026-04-14 20:11:04 UTC 2026-08-22 06:22:51 UTC Avapritinib SmallMolecule Avapritinib is an organic compound with the formula C26H27FN10 and an average molecular weight of 498.57 g/mol. Avapritinib belongs to the piperazines, a subclass of diazinanes within the organic compounds. This compound is classified as an antineoplastic agent and is found in healthcare, pharmaceuticals, and veterinary products. Its recorded route of exposure is oral. Avapritinib acts as an inhibitor for two protein targets: the Platelet-derived growth factor receptor alpha (PDGFRA) and the Mast/stem cell growth factor receptor Kit (KIT). C26H27FN10 498.57 498.240419072 1703793-34-3 CN1C=C(C=N1)C1=CN2N=CN=C(N3CCN(CC3)C3=NC=C(C=N3)[C@@](C)(N)C3=CC=C(F)C=C3)C2=C1 InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1 DWYRIWUZIJHQKQ-SANMLTNESA-N Detected and Not Quantified Avapritinib Drug Metabolism SMP0130893 Avapritinib Drug Metabolism Action Pathway SMP0145241 logp 3.26 average_mass 498.57 ChemAxon mono_mass 498.240419072 ChemAxon smiles CN1C=C(C=N1)C1=CN2N=CN=C(N3CCN(CC3)C3=NC=C(C=N3)[C@@](C)(N)C3=CC=C(F)C=C3)C2=C1 ChemAxon formula C26H27FN10 ChemAxon inchi InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1 ChemAxon inchikey DWYRIWUZIJHQKQ-SANMLTNESA-N ChemAxon #<HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3bf30d44c8> DB15233 118023034 BE0000453 BE0000852