<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 20:17:57 UTC</creation_date>
  <update_date>2026-08-22 03:51:16 UTC</update_date>
  <accession/>
  <common_name>Trilaciclib</common_name>
  <class>SmallMolecule</class>
  <description>Trilaciclib is an organic compound with the chemical formula C24H30N8O and an average molecular weight of 446.56 g/mol. Trilaciclib belongs to the piperazines, a subclass of diazinanes within the organic compounds.

This compound is associated with two recorded sources: electrical and electronic equipment, specifically electric hearing aids, and healthcare, pharmaceuticals and veterinary products, specifically unclassified therapeutic products. The recorded route of exposure for this substance is intravenous.

In terms of biological activity, trilaciclib acts on six recorded protein targets. It functions as an inhibitor of cyclin-dependent kinase 2 (CDK2), cyclin-dependent kinase 4 (CDK4), cyclin-dependent kinase 6 (CDK6), and cyclin-dependent kinase 9 (CDK9), in addition to two other proteins.</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C24H30N8O</chemical_formula>
  <average_molecular_weight>446.559</average_molecular_weight>
  <monisotopic_moleculate_weight>446.254257618</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1374743-00-6</cas_registry_number>
  <smiles>CN1CCN(CC1)C1=CN=C(NC2=NC3=C(C=C4N3C3(CCCCC3)CNC4=O)C=N2)C=C1</smiles>
  <inchi>InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)</inchi>
  <inchikey>PDGKHKMBHVFCMG-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Trilaciclib Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0145246</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>2.74</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>446.559</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>446.254257618</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CN1CCN(CC1)C1=CN=C(NC2=NC3=C(C=C4N3C3(CCCCC3)CNC4=O)C=N2)C=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C24H30N8O</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C24H30N8O/c1-30-9-11-31(12-10-30)18-5-6-20(25-15-18)28-23-26-14-17-13-19-22(33)27-16-24(7-3-2-4-8-24)32(19)21(17)29-23/h5-6,13-15H,2-4,7-12,16H2,1H3,(H,27,33)(H,25,26,28,29)</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>PDGKHKMBHVFCMG-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f721f43e390&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB15442</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>68029831</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
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  <biocyc_id/>
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