<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 20:23:54 UTC</creation_date>
  <update_date>2026-08-19 15:08:18 UTC</update_date>
  <accession/>
  <common_name>Fezolinetant</common_name>
  <class>SmallMolecule</class>
  <description>Fezolinetant is an organic compound with the formula C16H15FN6OS and an average molecular weight of 358.40 g/mol. Fezolinetant belongs to the benzoic acids and derivatives, a subclass of benzene and substituted derivatives within the organic compounds. It acts as an antagonist of the Neuromedin-K receptor (TACR3). This compound is recorded as a source in healthcare, pharmaceuticals, and veterinary products, specifically within gynecologicals, and is administered via the oral exposure route.</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C16H15FN6OS</chemical_formula>
  <average_molecular_weight>358.4</average_molecular_weight>
  <monisotopic_moleculate_weight>358.101208464</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1629229-37-3</cas_registry_number>
  <smiles>C[C@H]1N(CCN2C1=NN=C2C1=NC(C)=NS1)C(=O)C1=CC=C(F)C=C1</smiles>
  <inchi>InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1</inchi>
  <inchikey>PPSNFPASKFYPMN-SECBINFHSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>1.78</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>358.4</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>358.101208464</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>C[C@H]1N(CCN2C1=NN=C2C1=NC(C)=NS1)C(=O)C1=CC=C(F)C=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C16H15FN6OS</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>PPSNFPASKFYPMN-SECBINFHSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3baf1b8f40&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB15669</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>117604931</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
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  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
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      <target_id>BE0002371</target_id>
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</compound>
