<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 20:38:25 UTC</creation_date>
  <update_date>2026-08-21 18:48:44 UTC</update_date>
  <accession/>
  <common_name>Finerenone</common_name>
  <class>SmallMolecule</class>
  <description>Finerenone is an organic compound with the formula C21H22N4O3 and an average molecular weight of 378.43 g/mol. Finerenone belongs to the naphthyridines, a subclass of diazanaphthalenes within the organic compounds. It is recorded as a pharmaceutical product used as a diuretic and is administered via the oral exposure route. In terms of its biological activity, it acts as an antagonist of the mineralocorticoid receptor (NR3C2).</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C21H22N4O3</chemical_formula>
  <average_molecular_weight>378.432</average_molecular_weight>
  <monisotopic_moleculate_weight>378.169190584</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1050477-31-0</cas_registry_number>
  <smiles>CCOC1=NC=C(C)C2=C1[C@H](C1=CC=C(C=C1OC)C#N)C(C(N)=O)=C(C)N2</smiles>
  <inchi>InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1</inchi>
  <inchikey>BTBHLEZXCOBLCY-QGZVFWFLSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Finerenone Action Pathway</name>
      <smpdb_id>SMP0126009</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Finerenone Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0145287</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>1.85</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>378.432</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>378.169190584</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CCOC1=NC=C(C)C2=C1[C@H](C1=CC=C(C=C1OC)C#N)C(C(N)=O)=C(C)N2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C21H22N4O3</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>BTBHLEZXCOBLCY-QGZVFWFLSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7226c873b0&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB16165</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>60150535</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
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  <pdb_id/>
  <wikipidia/>
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</compound>
