<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 20:41:17 UTC</creation_date>
  <update_date>2026-08-22 03:28:23 UTC</update_date>
  <accession/>
  <common_name>Mitapivat</common_name>
  <class>SmallMolecule</class>
  <description>Mitapivat is an organic compound with the formula C24H26N4O3S and an average molecular weight of 450.56 g/mol. Mitapivat belongs to the quinolines and derivatives, a class of organoheterocyclic compounds within the organic compounds.

This compound is found in or released from two recorded sources: healthcare, pharmaceuticals &amp; veterinary products, specifically within hematological agents and gynecologicals. The recorded route of exposure for this substance is oral. Mitapivat interacts with two recorded protein targets, acting as an activator or inhibitor of Pyruvate kinase PKLR and Aromatase (CYP19A1).</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C24H26N4O3S</chemical_formula>
  <average_molecular_weight>450.56</average_molecular_weight>
  <monisotopic_moleculate_weight>450.172561887</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1260075-17-9</cas_registry_number>
  <smiles>O=C(N1CCN(CC2CC2)CC1)C1=CC=C(NS(=O)(=O)C2=CC=CC3=C2N=CC=C3)C=C1</smiles>
  <inchi>InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2</inchi>
  <inchikey>XAYGBKHKBBXDAK-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways>
    <pathway>
      <name>Mitapivat Drug Metabolism Action Pathway</name>
      <smpdb_id>SMP0145289</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>1.62</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>450.56</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>450.172561887</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>O=C(N1CCN(CC2CC2)CC1)C1=CC=C(NS(=O)(=O)C2=CC=CC3=C2N=CC=C3)C=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C24H26N4O3S</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C24H26N4O3S/c29-24(28-15-13-27(14-16-28)17-18-6-7-18)20-8-10-21(11-9-20)26-32(30,31)22-5-1-3-19-4-2-12-25-23(19)22/h1-5,8-12,18,26H,6-7,13-17H2</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>XAYGBKHKBBXDAK-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
  <mechanism_of_toxicity/>
  <metabolism/>
  <toxicity/>
  <lethaldose/>
  <carcinogenicity/>
  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f3baf8b2940&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB16236</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>59634741</pubchem_compound_id>
  <chembl_id/>
  <chemspider_id/>
  <kegg_id/>
  <uniprot_id/>
  <omim_id/>
  <chebi_id/>
  <biocyc_id/>
  <ctd_id/>
  <stitch_id/>
  <actor_id/>
  <pdb_id/>
  <wikipidia/>
  <general_references/>
  <targets>
    <target>
      <target_id/>
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      <target_id>BE0000046</target_id>
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      <target_id>BE0002090</target_id>
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</compound>
