<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <version>1.0</version>
  <creation_date>2026-04-14 21:31:38 UTC</creation_date>
  <update_date>2026-08-21 23:29:55 UTC</update_date>
  <accession/>
  <common_name>Belvarafenib</common_name>
  <class>SmallMolecule</class>
  <description>Belvarafenib is an organic compound with the chemical formula C23H16ClFN6OS and an average molecular weight of 478.93 g/mol. Belvarafenib belongs to the isoquinolines and derivatives, a class of organoheterocyclic compounds within the organic compounds.

In terms of biological activity, the compound acts as an inhibitor of the RAF proto-oncogene serine/threonine-protein kinase (RAF1).

Belvarafenib has been identified in or released from nine recorded sources. Within the category of electrical and electronic equipment, it is associated with antennas, electric hearing aids, line transmission systems, microphones, relays, and one additional source. In the building and construction sector, it is found in ladders as well as tents or canopies. Additionally, it is linked to food, food processing and cookware, specifically regarding the treatment of hops.</description>
  <categories/>
  <types/>
  <synonyms/>
  <chemical_formula>C23H16ClFN6OS</chemical_formula>
  <average_molecular_weight>478.93</average_molecular_weight>
  <monisotopic_moleculate_weight>478.0778862</monisotopic_moleculate_weight>
  <iupac_name/>
  <traditional_iupac/>
  <cas_registry_number>1446113-23-0</cas_registry_number>
  <smiles>CC1=C(NC(=O)C2=CSC3=C(N)N=CN=C23)C2=CC=NC(NC3=CC=CC(Cl)=C3F)=C2C=C1</smiles>
  <inchi>InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)</inchi>
  <inchikey>KVCQTKNUUQOELD-UHFFFAOYSA-N</inchikey>
  <taxonomy>
    <kingdom/>
    <super_class/>
    <class/>
    <sub_class/>
    <direct_parent/>
    <alternate_parents/>
    <substituents/>
    <molecular_framework/>
    <descriptors/>
  </taxonomy>
  <status>Detected and Not Quantified</status>
  <origin/>
  <cellular_locations/>
  <biofluid_locations/>
  <tissue_locations/>
  <pathways/>
  <state/>
  <appearance/>
  <experimental_properties>
    <property>
      <kind>logp</kind>
      <value>5.24</value>
    </property>
  </experimental_properties>
  <predicted_properties>
    <property>
      <kind>average_mass</kind>
      <value>478.93</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>mono_mass</kind>
      <value>478.0778862</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>smiles</kind>
      <value>CC1=C(NC(=O)C2=CSC3=C(N)N=CN=C23)C2=CC=NC(NC3=CC=CC(Cl)=C3F)=C2C=C1</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>formula</kind>
      <value>C23H16ClFN6OS</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchi</kind>
      <value>InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)</value>
      <source>ChemAxon</source>
    </property>
    <property>
      <kind>inchikey</kind>
      <value>KVCQTKNUUQOELD-UHFFFAOYSA-N</value>
      <source>ChemAxon</source>
    </property>
  </predicted_properties>
  <route_of_exposure/>
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  <metabolism/>
  <toxicity/>
  <lethaldose/>
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  <use_source/>
  <min_risk_level/>
  <health_effects>#&lt;HealthEffect::ActiveRecord_Associations_CollectionProxy:0x00007f7275a94ec8&gt;</health_effects>
  <symptoms/>
  <treatment/>
  <drugbank_id>DB17568</drugbank_id>
  <hmdb_id/>
  <pubchem_compound_id>89655386</pubchem_compound_id>
  <chembl_id/>
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  <omim_id/>
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  <biocyc_id/>
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  <wikipidia/>
  <general_references/>
  <targets>
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</compound>
