Clofenotane (CED0000008)

Record Information

Version

1.0

Creation Date

2009-03-06 18:57:55 UTC

Update Date

2026-05-14 19:33:16 UTC

Accession Number

CHEM000010

Identification

Common Name

Clofenotane

Class

Small Molecule

Description

Clofenotane (C14H9Cl5) is an exogenous organic compound with an average molecular weight of 354.49 g/mol. It exists as a solid at room temperature. Clofenotane belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. Industrially and biologically, clofenotane is used as an insecticide (PMC2737010, PMC11207698), pesticide (PMC5464684, PMC10999928), organochlorine pesticide (PMC12536502, PMC7983487, PMC8477732, PMC9754092), and organochlorine insecticide (PMC6915086, PMC1761136). It serves as a bridged diphenyl acaricide and has been used in the treatment of malaria (PMC10895053, PMC11108254, PMC11253139, PMC11664077, PMC11873108, PMC12249414, PMC12648036, PMC12686108, PMC2721868, PMC2737010). Chemically and environmentally, it is categorized as a persistent organic pollutant (PMC12536502, PMC3282903, PMC4633696, PMC5983739, PMC8959818) and an environmental contaminant (PMC13306574). It has been used in High-Density Polyethylene and Low-Density Polyethylene. Clofenotane is a xenoestrogen (PMC10895053, PMC10901106, PMC3084477, PMC8395949), endocrine disruptor (PMC10664694, PMC12536502, PMC2685838, PMC4633696, PMC8539486, PMC9739031), and carcinogenic agent (PMC12536502, PMC3282903, PMC4633696, PMC5983739, PMC8959818). Health effects include increased risks of obesity (PMC10048338, PMC10598475, PMC11277516, PMC11672798, PMC11873108, PMC11916920, PMC12686108), overweight (PMC3295349, PMC4113857, PMC6312913, PMC8477732), and various cancers, including breast (PMC10895053, PMC11225013, PMC11253139, PMC11873108), liver (PMC2737010, PMC3496877), pancreatic (PMC2737010, PMC6394840), and ovarian, testicular, prostate, and cervical cancers (PMC13255893). Other effects include spontaneous abortion (PMC1069659, PMC2737010, PMC4827016), low birth weight (PMC1069659), cryptorchidism (PMC6358230), and hypospadias (PMC6358230, PMC8502235). Exposure occurs via inhalation (PMC10895053, PMC3084477, PMC3094425, PMC3496877, PMC7215452), oral, or touch routes. Sources include electrical and electronic equipment, food processing materials, household cleaning products, building materials, and household items. It targets several proteins, including the estrogen receptor (ESR1, ESR2), androgen receptor (AR), and various ATPase subunits and sodium channels.

Contaminant Type

Cigarette Toxin
Food Toxin
Metabolite
Organic Compound
Organochloride
Pesticide
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1,1'-(2,2,2-Trichloroethylidene)bis[4-chlorobenzene]	ChEBI
1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane	ChEBI
1,1,1-Trichloro-2,2-bis-(4'-chlorophenyl)ethane	ChEBI
1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethane	ChEBI
4,4'-DDT	ChEBI
alpha,alpha-Bis(p-chlorophenyl)-beta,beta,beta-trichlorethane	ChEBI
Dichlorodiphenyltrichloroethane	ChEBI
p,P'-DDT	ChEBI
p,P'-dichlorodiphenyltrichloroethane	ChEBI
Dichlorojiphinyltrichloroethane	Kegg
DDT	Kegg
a,a-Bis(p-chlorophenyl)-b,b,b-trichlorethane	Generator
Α,α-bis(p-chlorophenyl)-β,β,β-trichlorethane	Generator
1,1'-(2,2,2-Trichloroethane-1,1-diyl)bis(4-chlorobenzene)	HMDB
1,1'-(2,2,2-Trichloroethylidene)bis(4-chloro)-benzene	HMDB
1,1'-(2,2,2-Trichloroethylidene)bis(4-chlorobenzene), 9ci	HMDB
1,1,1-trichloro-2,2-Bis(4,4'-dichlorodiphenyl)ethane	HMDB
1,1,1-trichloro-2,2-Bis(4-chlorophenyl)-ethane	HMDB
1,1,1-trichloro-2,2-Bis(P-chlorophenyl)-ethane	HMDB
1,1,1-trichloro-2,2-Bis(P-chlorophenyl)ethane	HMDB, MeSH
1,1,1-trichloro-2,2-Di(4-chlorophenyl)-ethane	HMDB
1,1,1-trichloro-2-2-Bis(4-chlorophenyl)ethane	HMDB
1,1,1-Trichlorobis(chlorophenyl)ethane	HMDB
1,1-Bis(P-chlorophenyl)-2,2,2-trichioroethane	HMDB
1,1-Bis-(P-chlorophenyl)-2,2,2-trichloroethane	HMDB
1-chloro-4-[2,2,2-trichloro-1-(4-Chlorophenyl)ethyl]benzene	HMDB
2,2,2-trichloro-1,1-Bis(4-chlorophenyl)ethane	HMDB
2,2,2-trichloro-1,1-Bis(P-chlorophenyl)-ethane	HMDB
2,2,2-Trichlorobis(4-chlorophenyl)ethane	HMDB
2,2-Bis(P-chlorophenyl)-1,1,1-trichloroethane	HMDB
Bis(P-chlorophenyl)-2,2,2-trichloroethane	HMDB
Chlofenotan	HMDB
Chlorophenothane	HMDB, MeSH
Chlorphenotane	HMDB
Dicophane, ban	HMDB
Diphenyltrichloroethane	HMDB
P,P'-DDT, bsi	HMDB
Zeidane	HMDB
Zerdane	HMDB
Zithiol	HMDB
TbisC-ethane	MeSH, HMDB
Benzochloryl	MeSH, HMDB
P',p'-DDT	MeSH, HMDB
4,4' Dichlorodiphenyltrichloroethane	MeSH, HMDB
4,4' DDT	MeSH, HMDB
4,4'-Dichlorodiphenyltrichloroethane	MeSH, HMDB
TbisC ethane	MeSH, HMDB
Clofenotane	ChEBI

Chemical Formula

C₁₄H₉Cl₅

Average Molecular Mass

354.486 g/mol

Monoisotopic Mass

351.915 g/mol

CAS Registry Number

50-29-3

IUPAC Name

1-chloro-4-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]benzene

Traditional Name

detox

SMILES

ClC1=CC=C(C=C1)C(C1=CC=C(Cl)C=C1)C(Cl)(Cl)Cl

InChI Identifier

InChI=1S/C14H9Cl5/c15-11-5-1-9(2-6-11)13(14(17,18)19)10-3-7-12(16)8-4-10/h1-8,13H

InChI Key

YVGGHNCTFXOJCH-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Diphenylmethanes

Direct Parent

Diphenylmethanes

Alternative Parents

Substituents

Diphenylmethane
Halobenzene
Chlorobenzene
Aryl halide
Aryl chloride
Hydrocarbon derivative
Organochloride
Organohalogen compound
Alkyl halide
Alkyl chloride
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

organochlorine insecticide (CHEBI:16130 )
monochlorobenzenes (CHEBI:16130 )
chlorophenylethane (CHEBI:16130 )
benzenoid aromatic compound (CHEBI:16130 )
Organochlorine pesticides (C04623 )
Organochlorine insecticides (C04623 )
an insecticide (CPD-43 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

bridged diphenyl acaricide

Biological Roles

Chemical Roles

persistent organic pollutant

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	108.5 - 109°C
Boiling Point	Not Available
Solubility	5.5e-06 mg/mL at 25°C

Predicted Properties

Property	Value	Source
Water Solubility	3.5e-06 g/L	ALOGPS
logP	6.29	ALOGPS
logP	6.46	ChemAxon
logS	-8	ALOGPS
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	85.32 m³·mol⁻¹	ChemAxon
Polarizability	32.28 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum	splash10-000i-3390000000-676266969a9e4afcfeb3	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-4590000000-8e90af62825794d4ed32	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-0390000000-a23b93b08974f28c17ea	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-2690000000-56d8c5298b5593a66540	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-3390000000-676266969a9e4afcfeb3	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-4590000000-8e90af62825794d4ed32	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-0390000000-a23b93b08974f28c17ea	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-000i-2690000000-56d8c5298b5593a66540	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-000i-2391000000-465776e134f2d14e4200	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-e4d354c1abce5df3562f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-5eec9abfcedc700c1772	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-014i-0019000000-c51586281a4bc626b427	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-9ede63c6934bd954c6fa	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-1339aaa8050c984b8945	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-03di-0009000000-80a4d52beed84a9206f1	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-dd77118949b674041bd9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-dd77118949b674041bd9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-0092000000-b7ea5b5c363c85b85916	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-17d9b4a570d431baa8a9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-17d9b4a570d431baa8a9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-17d9b4a570d431baa8a9	Not Available	View Spectrum
MS	MS Spectrum	splash10-000i-2590000000-25fc1b81a71c7822ba39	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

DDT toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDT reduces potassium transport across the membrane. DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. DDT inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. DDT also inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. All these inhibited functions reduce the rate of depolarization and increase the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. DDT is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (8, 2)

Carcinogenicity (IARC Classification)

DDT is possibly carcinogenic to humans (Group 2B). (7)

Minimum Risk Level

Acute Oral: 0.0005 mg/kg/day (3) Intermediate Oral: 0.0005 mg/kg/day (3)

Symptoms

Acute signs of DDT poisoning include paresthesia after oral ingestion. Studies have shown that a mammal poisoned with DDT-type agents displays periodic persistent tremoring and/or convulsive seizures that are suggestive of repetitive discharges in neurons. These repetitive tremors and seizures can be initiated by tactile and auditory stimuli. (8)

Treatment

Treatment of DDT exposure should be primarily directed towards decontamination and supportive care, as there is no specific antidote. The use of gastric lavage and activated charcoal for large ingestions may be effective. (5)

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
87.0	mg/kg	Not Available	Rat	LD50	Oral	experimental	L141
1931.0	mg/kg	Not Available	Rat	LD50	Dermal	experimental	L141
1500.0	mg/kg	Not Available	Rat	LD50	Subcutaneous	experimental	L141

Health Effects

Health Effect	Relationship	Direction	Reference
hypertension	associated_with	Not Available	PMC12686108
blood pressure	associated_with	Not Available	PMC12686108
inflammation	associated_with	Not Available	PMC12686108
cancer	associated_with	Not Available	PMC10048338 , PMC10895053 , PMC10895053 , PMC3439832 , PMC4949043 , PMC4949043 , PMC5409556 , PMC7610456 , PMC8395949
malaria	is_treatment_for	Not Available	PMC10895053 , PMC11108254 , PMC11253139 , PMC11664077 , PMC11873108 , PMC12249414 , PMC12648036 , PMC12686108 , PMC2721868 , PMC2737010
leishmaniasis	is_treatment_for	Not Available	PMC10895053 , PMC11108254 , PMC5629760 , PMC5629760
breast cancer	associated_with	increase	PMC10895053 , PMC10895053 , PMC11225013 , PMC11253139 , PMC11873108 , PMC11873108 , PMC11873108 , PMC11873108 , PMC11873108 , PMC11873108
breast cancer	associated_with	Not Available	PMC11873108 , PMC11873108
low birth weight	associated_with	increase	PMC1069659
type 2 diabetes mellitus	associated_with	Not Available	PMC2759028 , PMC8477732
overweight	associated_with	increase	PMC3295349 , PMC3295349 , PMC3295349 , PMC4113857 , PMC6312913 , PMC8477732
overweight	associated_with	Not Available	PMC3295349
abortion	associated_with	Not Available	PMC11225013
cervical cancer	associated_with	Not Available	PMC13255893 , PMC13255893
cervical cancer	elevated_in_blood_in	increase	PMC13255893
endometrial cancer	associated_with	Not Available	PMC4933552
Prostate cancer	associated_with	increase	PMC13255893 , PMC13255893
liver cancer	associated_with	increase	PMC2737010 , PMC3496877
leukemia	associated_with	increase	PMC5453502
obesity	associated_with	increase	PMC10048338 , PMC10598475 , PMC11277516 , PMC11672798 , PMC11873108 , PMC11873108 , PMC11873108 , PMC11873108 , PMC11916920 , PMC12686108
obesity	associated_with	Not Available	PMC11873108
congenital hypothyroidism	associated_with	increase	PMC7009407
congenital hypothyroidism	elevated_in_blood_in	increase	PMC2737010
lymphoma	associated_with	Not Available	PMC6625894
hyperuricemia	associated_with	Not Available	PMC13307085
cognitive impairment	associated_with	Not Available	PMC11225013
male infertility	associated_with	increase	PMC13411564
male infertility	associated_with	Not Available	PMC11672798
testicular cancer	associated_with	Not Available	PMC13255893 , PMC13255893 , PMC13255893
ovarian cancer	associated_with	increase	PMC13255893 , PMC13255893 , PMC13255893
disease	associated_with	Not Available	PMC5287152
aplastic anemia	associated_with	Not Available	PMC2737010
miscarriage	associated_with	Not Available	PMC7103533
breast	associated_with	increase	PMC13255893 , PMC13255893 , PMC13255893
pancreatic cancer	associated_with	Not Available	PMC2737010 , PMC6394840
non-Hodgkin lymphoma	associated_with	Not Available	PMC11664077 , PMC3734498 , PMC6351946
spontaneous abortion	associated_with	increase	PMC1069659 , PMC2737010 , PMC4827016
neurodegenerative disease	associated_with	Not Available	PMC6826260
cryptorchidism	associated_with	Not Available	PMC6358230
neurodevelopmental delay	associated_with	Not Available	PMC4827016
hypospadias	associated_with	Not Available	PMC6358230 , PMC8502235
visceral leishmaniasis	is_treatment_for	Not Available	PMC8539486
Japanese encephalitis	is_treatment_for	Not Available	PMC11108254
carcinoma	associated_with	Not Available	PMC10895053
trypanosomiasis	is_treatment_for	Not Available	PMC7886647
typhus	is_treatment_for	Not Available	PMC6826260 , PMC6915086
bubonic plague	is_treatment_for	Not Available	PMC9761600

Exposure Sources

Source ID	Source	Sector	Reference
10	Insecticides	Agriculture & land management	Not Available
233	Brushes	Personal care & cosmetics	Not Available
494	Food contact materials	Food, food processing & cookware	Not Available
495	Ceilings	Building & Construction	Not Available
499	Roofs	Building & Construction	Not Available
505	Amplifiers	Electrical & Electronic Equipment	Not Available
506	Antennas	Electrical & Electronic Equipment	Not Available
507	Auxiliary Devices	Electrical & Electronic Equipment	Not Available
509	Colour Television Systems	Electrical & Electronic Equipment	Not Available
511	Conductors Or Conductive Bodies Characterised By The Conductive Materials	Electrical & Electronic Equipment	Not Available
514	Discharge Lamps	Electrical & Electronic Equipment	Not Available
516	Electric Hearing Aids	Electrical & Electronic Equipment	Not Available
517	Electric Switches	Electrical & Electronic Equipment	Not Available
518	Electrically Stimulated Smoking Devices	Electrical & Electronic Equipment	Not Available
519	Electrodes	Electrical & Electronic Equipment	Not Available
521	Fixed Capacitors And Their Manufacture	Electrical & Electronic Equipment	Not Available
524	Hybrid Capacitors	Electrical & Electronic Equipment	Not Available
525	Line Transmission Systems	Electrical & Electronic Equipment	Not Available
527	Magnets	Electrical & Electronic Equipment	Not Available
530	Radio Transmission Systems	Electrical & Electronic Equipment	Not Available
531	Relays	Electrical & Electronic Equipment	Not Available
533	Sparking Plugs	Electrical & Electronic Equipment	Not Available
537	Television Systems	Electrical & Electronic Equipment	Not Available
538	Thin Magnetic Films	Electrical & Electronic Equipment	Not Available
539	Video Games	Electrical & Electronic Equipment	Not Available
540	X Ray Tubes	Electrical & Electronic Equipment	Not Available
544	Fermentation Processes For Beer	Food, food processing & cookware	Not Available
545	Food Preservation	Food, food processing & cookware	Not Available
546	Molasses And Treatment Of Molasses	Food, food processing & cookware	Not Available
547	Preparation Of Malt	Food, food processing & cookware	Not Available
548	Preparation Of Vinegar	Food, food processing & cookware	Not Available
549	Preparation Of Wine Or Sparkling Wine	Food, food processing & cookware	Not Available
552	Processing Meats	Food, food processing & cookware	Not Available
553	Treatment Of Hops	Food, food processing & cookware	Not Available
556	Cigar Cigarettes	Household cleaning & consumer products	Not Available
559	Non Electric Simulated Smoking Devices	Household cleaning & consumer products	Not Available
560	Other Smoking Requisites	Household cleaning & consumer products	Not Available
561	Perfumes Within Detergents And Soaps	Household cleaning & consumer products	Not Available
562	Pipe Accessories	Household cleaning & consumer products	Not Available
563	Soap Detergents	Household cleaning & consumer products	Not Available
566	Tobacco Pipes	Household cleaning & consumer products	Not Available
569	Tobacco Smoke Filters	Household cleaning & consumer products	Not Available
572	Credit Card Holders	Household items	Not Available
578	Making Cigars	Industrial manufacturing & chemical processing	Not Available
579	Manufacture Of Iron Or Steel	Industrial manufacturing & chemical processing	Not Available
580	Manufacture Preparation Of Tobacco Products	Industrial manufacturing & chemical processing	Not Available
583	Anchoring Equipment	Marine, shipping & aquaculture	Not Available
588	Inflatable Life Saving Equipment	Marine, shipping & aquaculture	Not Available
589	Life Buoys	Marine, shipping & aquaculture	Not Available
592	Marine Propulsion Or Steering	Marine, shipping & aquaculture	Not Available
596	Acaricides	Agriculture & land management	Not Available
597	Chemosterilants	Agriculture & land management	Not Available
598	Fertiliser Distributors	Agriculture & land management	Not Available
600	Herbicides And Algicides	Agriculture & land management	Not Available
602	Molluscicides	Agriculture & land management	Not Available
603	Nematocides	Agriculture & land management	Not Available
604	Pest Attractants	Agriculture & land management	Not Available
605	Pest Repellants	Agriculture & land management	Not Available
606	Plant Growth Regulators	Agriculture & land management	Not Available
607	Rodenticides(1)	Agriculture & land management	Not Available
608	Rodenticides	Agriculture & land management	Not Available
609	Aftershave	Personal care & cosmetics	Not Available
610	Aftersun Products	Personal care & cosmetics	Not Available
611	Anti Perspirants Or Body Deoderants	Personal care & cosmetics	Not Available
614	Essential Oils Or Perfumes	Personal care & cosmetics	Not Available
615	Eye Makeup Products	Personal care & cosmetics	Not Available
616	Face Mask Cosmetics	Personal care & cosmetics	Not Available
617	Lip Care Products	Personal care & cosmetics	Not Available
618	Lip Makeup Products	Personal care & cosmetics	Not Available
620	Card Games	Recreation & sports surfaces	Not Available
630	Toys	Recreation & sports surfaces	Not Available
632	Apparel	Textiles, leather & furnishings	Not Available
634	Buckles	Textiles, leather & furnishings	Not Available
641	Foam Dyeing	Textiles, leather & furnishings	Not Available
642	Footwear	Textiles, leather & furnishings	Not Available
650	Purses Luggage Hand Bags	Textiles, leather & furnishings	Not Available
653	Sewing	Textiles, leather & furnishings	Not Available
662	Yarns Or Threads	Textiles, leather & furnishings	Not Available

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Predicted (SEA)	211.283
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	444.986
Click to view 3D structure	Sodium-dependent dopamine transporter	P23977	Rattus norvegicus	Predicted (SEA)	243.123
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	395.785
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	769.929
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Predicted (SEA)	347.597
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	288.042
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	3011.91
Click to view 3D structure	Aromatase	P22443	Rattus norvegicus	Predicted (SEA)	1.47914
Click to view 3D structure	Androgen receptor	P15207	Rattus norvegicus	Predicted (SEA)	87.5804
Click to view 3D structure	Aromatase	P11511	Humans	Predicted (SEA)	316.457
Click to view 3D structure	Superoxide dismutase [Cu-Zn]	P00441	Humans	Predicted (SEA)	21.175
Click to view 3D structure	Glutamate (NMDA) receptor subunit zeta 1	O19067	Sus scrofa	Predicted (SEA)	60.6445
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	5877.77
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	3388.62
Click to view 3D structure	Transporter	Q63380	Rattus norvegicus	Predicted (SEA)	271.927
Click to view 3D structure	RAC-alpha serine/threonine-protein kinase	P31749	Humans	Predicted (SEA)	4153.41
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Predicted (SEA)	2665.64
Click to view 3D structure	Cytochrome P450 1A2	P05177	Humans	Predicted (SEA)	4840.43
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	3320.11
Click to view 3D structure	Adenosine receptor A3	P0DMS8	Humans	Predicted (SEA)	2338.36
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	3197.11
Click to view 3D structure	Histamine H1 receptor	P35367	Humans	Predicted (SEA)	3872.77
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	4581.04
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	4969.89
Click to view 3D structure	Nuclear receptor subfamily 1 group I member 2	O75469	Humans	Known	Not Available
Click to view 3D structure	Estrogen receptor	P03372	Humans	Known	Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (A590)
Click to view 3D structure	Androgen receptor	P10275	Humans	Known	DDT is also believed to adversely affect the reproductive system by mimicking endogenous hormones and binding to the estrogen and adrogen receptors. (L85)
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Known	Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (A590)
Click to view 3D structure	Aryl hydrocarbon receptor	P35869	Humans	Known	Not Available
Click to view 3D structure	Calcium-transporting ATPase type 2C member 1	P98194	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	G-protein coupled estrogen receptor 1	Q99527	Humans	Known	Not Available
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-1	P14867	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-2	P47869	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-3	P34903	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-5	P31644	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-6	Q16445	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-1	P18505	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-2	P47870	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-3	P28472	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit delta	O14764	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit epsilon	P78334	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-1	Q8N1C3	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-2	P18507	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-3	Q99928	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit pi	O00591	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-1	P24046	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-2	P28476	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-3	A8MPY1	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit theta	Q9UN88	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	Q9UL51	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Progesterone receptor	P06401	Humans	Known	Not Available
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	O14983	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P16615	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium channel protein type 1 subunit alpha	P35498	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 10 subunit alpha	Q9Y5Y9	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 11 subunit alpha	Q9UI33	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 2 subunit alpha	Q99250	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 3 subunit alpha	Q9NY46	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 4 subunit alpha	P35499	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 5 subunit alpha	Q14524	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 8 subunit alpha	Q9UQD0	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel protein type 9 subunit alpha	Q15858	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel regulatory subunit beta-1	Q07699	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel regulatory subunit beta-2	O60939	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel regulatory subunit beta-3	Q9NY72	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium channel regulatory subunit beta-4	Q8IWT1	Humans	Known	DDT inhibits the inactivation of voltaged-gated sodium channels. The channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization and resulting in a state of hyperexcitability. (A99)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-1	P05023	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-2	P50993	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-3	P13637	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-4	Q13733	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-1	P05026	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-2	P14415	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-3	P54709	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit gamma	P54710	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Thyrotropin receptor	P16473	Humans	Known	Not Available
Click to view 3D structure	Hepatocyte nuclear factor 4-alpha	P41235	Humans	Known	Not Available