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This work was supported by the Canada Foundation for Innovation (CFI MSIF #42495), Genome Alberta, a division of Genome Canada, Genome Canada and the Canada Research Chairs Program (CRC Tier 1 #100628). Additional support was provided by the Natural Sciences and Engineering Research Council of Canada (NSERC) through a Discovery Grant (NSERC RGPIN-2025-04867), the NSERC Brockhouse Canada Prize (NSERC BCPIR-590317-2024) and the NSERC Gerhard Herzberg Canada Gold Medal (NSERC GLDSU 601838-2025).