Trichloroethylene (CED0000011)

Record Information

Version

1.0

Creation Date

2009-03-06 18:57:55 UTC

Update Date

2026-05-14 19:32:13 UTC

Accession Number

CHEM000014

Identification

Common Name

Trichloroethylene

Class

Small Molecule

Description

Trichloroethylene (C2HCl3) is an exogenous organic compound with an average molecular weight of 131.39 g/mol. Trichloroethylene belongs to the vinyl chlorides, a subclass of vinyl halides within the organic compounds. At room temperature, this organohalogen compound is a liquid. It serves as an industrial solvent (PMC12184642), an industrial additive (PMC2630226), and an inhalation anaesthetic. Biologically, it acts as an electron acceptor (PMC91463). It is used in the production of acrylonitrile butadiene styrene and polyvinyl chloride and is present in polyethylene terephthalate. As an environmental contaminant (PMC7272693), trichloroethylene is found in aquatic systems and sediments, including groundwater, surface water, seawater, and freshwater, as well as in drinking water, tap water, bottled water, and desalinated water. Other recorded sources include electrical and electronic equipment, building and construction materials, and household cleaning and consumer products. Exposure routes include oral, touch, and inhalation (PMC3889157, PMC4253867, PMC7272693). Health effects associated with trichloroethylene include hepatitis, toxic encephalopathy (PMC1007956), necrosis, and acute renal failure (PMC2847015). It is linked to low birth weight (PMC7103533) and various cancers, including childhood leukemia (PMC5161115), liver cancer (PMC9142031), pancreatic cancer (PMC6394840), renal cell carcinoma (PMC6310611), non-Hodgkin lymphoma (PMC12327356), and an increase in breast cancer (PMC11425761, PMC12327356), as well as cancer generally (PMC10218431, PMC8475335, PMC9961358). It causes endocrine disruption by inhibiting the estrogen receptor. Additionally, it antagonizes GABA-A receptors, causing central nervous system hyperexcitability, and inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, leading to intracellular free calcium ion accumulation. Its toxicity is largely attributed to metabolites such as chloral hydrate, trichloroacetic acid, and dichloroacetic acid.

Contaminant Type

Anesthetic
Cigarette Toxin
Food Toxin
Household Toxin
Human Neurotoxin
Industrial/Workplace Toxin
Metabolite
Organic Compound
Organochloride
PMT
Pollutant
Solvent
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1,1-Dichloro-2-chloroethylene	ChEBI
Acetylene trichloride	ChEBI
Ethinyl trichloride	ChEBI
Ethylene trichloride	ChEBI
Narcogen	ChEBI
TCE	ChEBI
Trichlor	ChEBI
Trichloraethylenum pro narcosi	ChEBI
Trichloraethen	ChEBI
Trichloraethylen	ChEBI
Trichlorethylene	ChEBI
Trichloroethylenum	ChEBI
Triciene	ChEBI
1,1,1-Trichloroethylene	HMDB
1,1,2-Trichloro-ethene	HMDB
1,1,2-Trichloroethene	HMDB
1,1,2-Trichloroethylene	HMDB
1,2,2-Trichloroethylene	HMDB
1-Chloro-2,2-dichloroethylene	HMDB
Algylen	HMDB
Altene DG	HMDB
Anamenth	HMDB
Benzinol	HMDB
Blacosolv	HMDB
Blancosolv	HMDB
C2HCL3	HMDB
Cecolene	HMDB
Chlorilen	HMDB
Chlorylea	HMDB
Chlorylen	HMDB
Chorylen	HMDB
Circosolv	HMDB
Crawhaspol	HMDB
Densi nfluat	HMDB
Densinfluat	HMDB
Disparit b	HMDB
Distillex DS2	HMDB
Dow-tri	HMDB
Dukeron	HMDB
Fleck-flip	HMDB
Flock flip	HMDB
Fluate	HMDB
Gemalgene	HMDB
Germalgene	HMDB
Lanadin	HMDB
Lethurin	HMDB
Narkogen	HMDB
Narkosoid	HMDB
Nialk	HMDB
Perm-a-chlor	HMDB
Perm-a-clor	HMDB
Petzinol	HMDB
Philex	HMDB
R 1120	HMDB
Tce (chlorohydrocarbon)	HMDB
Threthylen	HMDB
Threthylene	HMDB
Trethylene	HMDB
TRI	HMDB
Tri-clene	HMDB
Tri-plus	HMDB
Tri-plus m	HMDB
Trial	HMDB
Triasol	HMDB
Tric hloroethene	HMDB
Trichlooretheen	HMDB
Trichloorethyleen, tri	HMDB
Trichloraethylen, tri	HMDB
Trichloraethylenum	HMDB
Trichloran	HMDB
Trichlorathane	HMDB
Trichloren	HMDB
Trichlorethene	HMDB
Trichlorethylene, tri	HMDB
Trichlorethylenum	HMDB
Trichloride, ethinyl	HMDB
Trichloro-ethene	HMDB
Trichloro-ethylene	HMDB
Trichloroethene	HMDB
Trichloroethene, 9ci	HMDB
Trichloroethylene (iupac)	HMDB
Trichloroethylene (tce)	HMDB
Trichloroethylene (with epichlorohydrin)	HMDB
Trichloroethylene (without epichlorohydrin)	HMDB
Trichlorothene	HMDB
Tricloretene	HMDB
Tricloroetilene	HMDB
Tricloroetileno	HMDB
Trielene	HMDB
Trielin	HMDB
Trielina	HMDB
Trieline	HMDB
Trik lone	HMDB
Triklone	HMDB
Triklone N	HMDB
Trilen	HMDB
Trilene	HMDB
Trilene te-141	HMDB
Triline	HMDB
Trimar	HMDB
Triol	HMDB
Vestrol	HMDB
Vitran	HMDB
Westrosol	HMDB
Trichloroethylene	ChEBI

Chemical Formula

C₂HCl₃

Average Molecular Mass

131.388 g/mol

Monoisotopic Mass

129.914 g/mol

CAS Registry Number

1979-01-06

IUPAC Name

1,1,2-trichloroethene

Traditional Name

trichloroethylene

SMILES

ClC=C(Cl)Cl

InChI Identifier

InChI=1S/C2HCl3/c3-1-2(4)5/h1H

InChI Key

XSTXAVWGXDQKEL-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as vinyl chlorides. These are vinyl halides in which a chlorine atom is bonded to an sp2-hybridised carbon atom.

Kingdom

Organic compounds

Super Class

Organohalogen compounds

Class

Vinyl halides

Sub Class

Vinyl chlorides

Direct Parent

Vinyl chlorides

Alternative Parents

Substituents

Chloroalkene
Haloalkene
Vinyl chloride
Hydrocarbon derivative
Organochloride
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

chloroethenes (CHEBI:16602 )
a small molecule (TRICHLOROETHENE )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular
Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

inhalation anaesthetic

Biological Roles

electron acceptor

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Liquid

Appearance

Colorless liquid.

Experimental Properties

Property	Value
Melting Point	-84.8°C
Boiling Point	86.7°C (188.1°F)
Solubility	1.28 mg/mL at 25°C

Predicted Properties

Property	Value	Source
Water Solubility	1.96 g/L	ALOGPS
logP	2.45	ALOGPS
logP	2.18	ChemAxon
logS	-1.8	ALOGPS
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	35.18 m³·mol⁻¹	ChemAxon
Polarizability	9.59 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum	splash10-001j-9600000000-35bd416ad747042a0c53	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-001j-9800000000-152d0336467c74545ec4	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-03ea-9200000000-655b220bf877474e22b4	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-001j-9600000000-35bd416ad747042a0c53	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-001j-9800000000-152d0336467c74545ec4	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-03ea-9200000000-655b220bf877474e22b4	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-003v-7900000000-401c79c003cea991b031	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-1c5d55a90bcf42fd6a79	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-54723e87d2cf07e437d3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-9400000000-2160348c43ed061e6433	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0900000000-ddeffc3538dadd85ccfd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0900000000-ddeffc3538dadd85ccfd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0900000000-ddeffc3538dadd85ccfd	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-ebd2d5562c347d9a033c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-ebd2d5562c347d9a033c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0006-9000000000-60c1e7d06db736d34d7e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0900000000-8c6a5ccbef32738aa756	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-9000000000-c2fa753da65a4bac80a1	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-4900000000-ba44c814cacfb3422385	Not Available	View Spectrum
MS	MS Spectrum	splash10-001j-9600000000-1c547ee123cf751604dc	Not Available	View Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, predicted)	Not Available	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

The toxic and carcinogenic effects of trichloroethylene are believed to be caused mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase, while chloral hydrate inhibits alcohol dehydrogenase. Studies in rodents have shown that neurotoxic effects may be caused by trichloroethylene's incorporation into brain membranes or ability to alter the fatty acid pattern of brain phospholipids and amino acids. One of the mechanisms of trichloroethylene's carcinogenicity is believed to be the peroxisome proliferation induced by its metabolites. (19, 24, 1)

Carcinogenicity (IARC Classification)

1, carcinogenic to humans. (22)

Minimum Risk Level

Acute Inhalation: 2 ppm (21) Intermediate Inhalation: 0.1 ppm (21) Acute Oral: 0.2 mg/kg/day (21)

Symptoms

Inhalation of trichloroethylene causes headaches, lung irritation, dizziness, poor coordination, and difficulty concentrating, while ingestion results in nausea. Larger amounts may cause unconciousness and impaired heart function. Skin contact often results in rashes. (19)

Treatment

There is no known antidote for trichloroethylene. Exposure is usually handled with symptomatic treatment. (20)

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
2402.0	mg/kg	Not Available	Mouse	LD50	Oral	experimental	T18
20001.0	mg/kg	Not Available	Rabbit	LD50	Dermal	experimental	T18
3222.0	mg/kg	Not Available	Mouse	LD50	Intraperitoneal	experimental	T18

Health Effects

Health Effect	Relationship	Direction	Reference
cancer	associated_with	Not Available	PMC10218431 , PMC10218431 , PMC8475335 , PMC9961358
breast cancer	associated_with	increase	PMC11425761 , PMC11425761 , PMC12327356 , PMC12327356 , PMC12327356 , PMC12327356 , PMC12327356
low birth weight	associated_with	Not Available	PMC7103533
liver cancer	associated_with	Not Available	PMC9142031
necrosis	associated_with	Not Available	PMC2847015
hepatitis	associated_with	Not Available	PMC1007956
renal cell carcinoma	associated_with	Not Available	PMC6310611
acute renal failure	associated_with	Not Available	PMC2847015
childhood leukemia	associated_with	Not Available	PMC5161115
pancreatic cancer	associated_with	Not Available	PMC6394840
non-Hodgkin lymphoma	associated_with	Not Available	PMC12327356
Toxic encephalopathy	associated_with	Not Available	PMC1007956
kidney cancer	associated_with	increase	PMC2898922 , PMC9142031
spina bifida	associated_with	increase	PMC4429479 , PMC4429479 , PMC4429479
carpal tunnel syndrome	associated_with	Not Available	PMC11650800

Exposure Sources

Source ID	Source	Sector	Reference
3	Irrigation water	Agriculture & land management	Not Available
10	Insecticides	Agriculture & land management	Not Available
27	Water Coolers	Appliances, HVAC & refrigerants	Not Available
43	Water heaters	Appliances, HVAC & refrigerants	Not Available
50	Groundwater	Aquatic systems & sediments	Not Available
51	Surface water	Aquatic systems & sediments	Not Available
52	Seawater	Aquatic systems & sediments	Not Available
53	Freshwater	Aquatic systems & sediments	Not Available
70	Stormwater runoff	Automotive & urban infrastructure	Not Available
88	Waterproofing sprays	Building & Construction	Not Available
115	Drinking water	Drinking water & water supply	Not Available
116	Tap water	Drinking water & water supply	Not Available
117	Bottled water	Drinking water & water supply	Not Available
118	Desalinated water	Drinking water & water supply	Not Available
181	Ballast water	Marine, shipping & aquaculture	Not Available
182	Bilge water	Marine, shipping & aquaculture	Not Available
233	Brushes	Personal care & cosmetics	Not Available
468	Industrial wastewater	Wastewater, sanitation & biosolids	Not Available
470	Wastewater treatment effluent	Wastewater, sanitation & biosolids	Not Available
475	Mine wastewater	Wastewater, sanitation & biosolids	Not Available
477	Wastewater, unspecified	Wastewater, sanitation & biosolids	Not Available
494	Food contact materials	Food, food processing & cookware	Not Available
495	Ceilings	Building & Construction	Not Available
499	Roofs	Building & Construction	Not Available
500	Stairs And Ramps	Building & Construction	Not Available
501	Sunshades Awnings Or Outside Screens	Building & Construction	Not Available
502	Sunshades Awnings Or Outside Screens	Building & Construction	Not Available
503	Tents Or Canopies	Building & Construction	Not Available
504	Adjustable Resistors	Electrical & Electronic Equipment	Not Available
505	Amplifiers	Electrical & Electronic Equipment	Not Available
506	Antennas	Electrical & Electronic Equipment	Not Available
507	Auxiliary Devices	Electrical & Electronic Equipment	Not Available
508	Coils	Electrical & Electronic Equipment	Not Available
509	Colour Television Systems	Electrical & Electronic Equipment	Not Available
510	Communication Cables Or Conductors	Electrical & Electronic Equipment	Not Available
511	Conductors Or Conductive Bodies Characterised By The Conductive Materials	Electrical & Electronic Equipment	Not Available
513	Cores Yokes Or Armatures	Electrical & Electronic Equipment	Not Available
514	Discharge Lamps	Electrical & Electronic Equipment	Not Available
515	Discharge Tubes With Liquid Pool Cathodes	Electrical & Electronic Equipment	Not Available
517	Electric Switches	Electrical & Electronic Equipment	Not Available
518	Electrically Stimulated Smoking Devices	Electrical & Electronic Equipment	Not Available
519	Electrodes	Electrical & Electronic Equipment	Not Available
520	Emergency Protective Devices	Electrical & Electronic Equipment	Not Available
521	Fixed Capacitors And Their Manufacture	Electrical & Electronic Equipment	Not Available
523	Gas Filled Discharge Tubes With Solid Cathode	Electrical & Electronic Equipment	Not Available
524	Hybrid Capacitors	Electrical & Electronic Equipment	Not Available
527	Magnets	Electrical & Electronic Equipment	Not Available
529	Power Cables	Electrical & Electronic Equipment	Not Available
530	Radio Transmission Systems	Electrical & Electronic Equipment	Not Available
531	Relays	Electrical & Electronic Equipment	Not Available
532	Selectors	Electrical & Electronic Equipment	Not Available
533	Sparking Plugs	Electrical & Electronic Equipment	Not Available
536	Superconductive Or Hyperconductive Conductors Cables Or Transmission Lines	Electrical & Electronic Equipment	Not Available
537	Television Systems	Electrical & Electronic Equipment	Not Available
538	Thin Magnetic Films	Electrical & Electronic Equipment	Not Available
544	Fermentation Processes For Beer	Food, food processing & cookware	Not Available
545	Food Preservation	Food, food processing & cookware	Not Available
547	Preparation Of Malt	Food, food processing & cookware	Not Available
549	Preparation Of Wine Or Sparkling Wine	Food, food processing & cookware	Not Available
550	Preparation Of Wort	Food, food processing & cookware	Not Available
552	Processing Meats	Food, food processing & cookware	Not Available
553	Treatment Of Hops	Food, food processing & cookware	Not Available
555	Bleaching Agents	Household cleaning & consumer products	Not Available
556	Cigar Cigarettes	Household cleaning & consumer products	Not Available
559	Non Electric Simulated Smoking Devices	Household cleaning & consumer products	Not Available
560	Other Smoking Requisites	Household cleaning & consumer products	Not Available
561	Perfumes Within Detergents And Soaps	Household cleaning & consumer products	Not Available
563	Soap Detergents	Household cleaning & consumer products	Not Available
566	Tobacco Pipes	Household cleaning & consumer products	Not Available
569	Tobacco Smoke Filters	Household cleaning & consumer products	Not Available
572	Credit Card Holders	Household items	Not Available
578	Making Cigars	Industrial manufacturing & chemical processing	Not Available
579	Manufacture Of Iron Or Steel	Industrial manufacturing & chemical processing	Not Available
580	Manufacture Preparation Of Tobacco Products	Industrial manufacturing & chemical processing	Not Available
581	Paper Making Machines	Industrial manufacturing & chemical processing	Not Available
583	Anchoring Equipment	Marine, shipping & aquaculture	Not Available
584	Buoys	Marine, shipping & aquaculture	Not Available
589	Life Buoys	Marine, shipping & aquaculture	Not Available
592	Marine Propulsion Or Steering	Marine, shipping & aquaculture	Not Available
596	Acaricides	Agriculture & land management	Not Available
597	Chemosterilants	Agriculture & land management	Not Available
598	Fertiliser Distributors	Agriculture & land management	Not Available
600	Herbicides And Algicides	Agriculture & land management	Not Available
602	Molluscicides	Agriculture & land management	Not Available
603	Nematocides	Agriculture & land management	Not Available
604	Pest Attractants	Agriculture & land management	Not Available
605	Pest Repellants	Agriculture & land management	Not Available
606	Plant Growth Regulators	Agriculture & land management	Not Available
607	Rodenticides(1)	Agriculture & land management	Not Available
608	Rodenticides	Agriculture & land management	Not Available
609	Aftershave	Personal care & cosmetics	Not Available
610	Aftersun Products	Personal care & cosmetics	Not Available
611	Anti Perspirants Or Body Deoderants	Personal care & cosmetics	Not Available
612	Body Washing Or Cleaning Implements	Personal care & cosmetics	Not Available
614	Essential Oils Or Perfumes	Personal care & cosmetics	Not Available
615	Eye Makeup Products	Personal care & cosmetics	Not Available
617	Lip Care Products	Personal care & cosmetics	Not Available
618	Lip Makeup Products	Personal care & cosmetics	Not Available
619	Manicure Pedicure	Personal care & cosmetics	Not Available
630	Toys	Recreation & sports surfaces	Not Available
631	Anthraquinone Dyes	Textiles, leather & furnishings	Not Available
632	Apparel	Textiles, leather & furnishings	Not Available
633	Azo Dyes	Textiles, leather & furnishings	Not Available
634	Buckles	Textiles, leather & furnishings	Not Available
635	Buttons	Textiles, leather & furnishings	Not Available
638	Decorating Textiles	Textiles, leather & furnishings	Not Available
639	Degreasing Leather	Textiles, leather & furnishings	Not Available
640	Embroidering And Tufting	Textiles, leather & furnishings	Not Available
641	Foam Dyeing	Textiles, leather & furnishings	Not Available
642	Footwear	Textiles, leather & furnishings	Not Available
643	Headwear	Textiles, leather & furnishings	Not Available
647	Multicolour Dyeing	Textiles, leather & furnishings	Not Available
648	Nitro Dyes	Textiles, leather & furnishings	Not Available
650	Purses Luggage Hand Bags	Textiles, leather & furnishings	Not Available
651	Purses Money Bags Wallets	Textiles, leather & furnishings	Not Available
652	Ropes	Textiles, leather & furnishings	Not Available
653	Sewing	Textiles, leather & furnishings	Not Available
655	Slide Fasteners	Textiles, leather & furnishings	Not Available
657	Surface Finishing Of Leather	Textiles, leather & furnishings	Not Available
659	Transfer Printing	Textiles, leather & furnishings	Not Available
662	Yarns Or Threads	Textiles, leather & furnishings	Not Available

Pathways

1 pathway

Trichloroethylene Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Type IV secretion-like conjugative transfer relaxase protein TraI	B1LRJ1	Escherichia coli (strain SMS-3-5 / SECEC)	Predicted (SEA)	14.0907
Click to view 3D structure	Dihydropyrimidine dehydrogenase [NADP(+)]	Q12882	Humans	Predicted (SEA)	657.359
Click to view 3D structure	Cyclic AMP-dependent transcription factor ATF-1	P18846	Humans	Predicted (SEA)	5250.07
Click to view 3D structure	Nuclear factor NF-kappa-B p105 subunit	P19838	Humans	Predicted (SEA)	7591.23
Click to view 3D structure	Amine oxidase [flavin-containing] A	P21397	Humans	Predicted (SEA)	7783.29
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	7784.38
Click to view 3D structure	Acetylcholine receptor subunit beta-like 2	P25162	Drosophila melanogaster	Predicted (SEA)	7054.15
Click to view 3D structure	Kynurenine 3-monooxygenase	P38169	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	Predicted (SEA)	5463.69
Click to view 3D structure	Endothelin-converting enzyme 2	P0DPD6	Humans	Predicted (SEA)	2631.07
Click to view 3D structure	Alpha-2B adrenergic receptor	P18089	Humans	Predicted (SEA)	7784.07
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Predicted (SEA)	7784.22
Click to view 3D structure	Neuronal acetylcholine receptor subunit alpha-4	P09482	Gallus gallus	Predicted (SEA)	6899.15
Click to view 3D structure	Transthyretin	P02766	Humans	Predicted (SEA)	7763.75
Click to view 3D structure	Acetylcholine-binding protein	P58154	Lymnaea stagnalis	Predicted (SEA)	7744.6
Click to view 3D structure	Soluble acetylcholine receptor	Q8WSF8	Aplysia californica	Predicted (SEA)	7668.46
Click to view 3D structure	Alpha-2C adrenergic receptor	P18825	Humans	Predicted (SEA)	7784.14
Click to view 3D structure	Glutamate receptor ionotropic, NMDA 1	P35439	Rattus norvegicus	Predicted (SEA)	7742.18
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	7784.38
Click to view 3D structure	E3 ubiquitin-protein ligase pellino homolog 1	Q96FA3	Humans	Predicted (SEA)	3849.33
Click to view 3D structure	Protein phosphatase 1 regulatory subunit 15A	O75807	Humans	Predicted (SEA)	2979.91
Click to view 3D structure	Protein phosphatase 1 regulatory subunit 15B	Q5SWA1	Humans	Predicted (SEA)	2979.91
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	7784.53
Click to view 3D structure	Tyrosinase	P14679	Humans	Predicted (SEA)	7727.62
Click to view 3D structure	Tyrosine-protein kinase JAK3	P52333	Humans	Predicted (SEA)	7784.3
Click to view 3D structure	Neuronal acetylcholine receptor subunit alpha-7	P36544	Humans	Predicted (SEA)	7782.43
Click to view 3D structure	Estrogen receptor	P03372	Humans	Known	Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (A590)
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Known	Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (A590)
Click to view 3D structure	Alcohol dehydrogenase 1A	P07327	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	All-trans-retinol dehydrogenase [NAD(+)] ADH1B	P00325	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	Alcohol dehydrogenase 1C	P00326	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	All-trans-retinol dehydrogenase [NAD(+)] ADH4	P08319	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	Alcohol dehydrogenase 6	P28332	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	All-trans-retinol dehydrogenase [NAD(+)] ADH7	P40394	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	Alcohol dehydrogenase class-3	P11766	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Chloral hydrate inhibits alcohol dehydrogenase. (A51)
Click to view 3D structure	Calcium-transporting ATPase type 2C member 1	P98194	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-1	P14867	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-2	P47869	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-3	P34903	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-5	P31644	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-6	Q16445	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-1	P18505	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-2	P47870	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-3	P28472	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit delta	O14764	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit epsilon	P78334	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-1	Q8N1C3	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-2	P18507	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-3	Q99928	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit pi	O00591	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-1	P24046	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-2	P28476	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-3	A8MPY1	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit theta	Q9UN88	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	O14983	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P16615	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-1	P05023	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-2	P50993	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-3	P13637	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-4	Q13733	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-1	P05026	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-2	P14415	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-3	P54709	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit gamma	P54710	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Q15118	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (A50)
Click to view 3D structure	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (A50)
Click to view 3D structure	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	Q15120	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (A50)
Click to view 3D structure	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	Q16654	Humans	Known	The toxic and carcinogenic effects of trichloroethylene are believed to be cause mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and chloral hydrate. The nephrotoxicity and nephrocarcinogenicity of TRI have been attributed to glutathione conjunction, which forms reactive, sulfur-containing metabolites. Dichloroacetic acid is known to inhibit pyruvate dehydrogenase kinase. (A50)