1,2-Dibromo-3-chloropropane (CED0000030)

Record Information

Version

1.0

Creation Date

2009-03-06 18:57:58 UTC

Update Date

2026-08-22 12:57:55 UTC

Accession Number

CHEM000040

Identification

Common Name

1,2-Dibromo-3-chloropropane

Class

Small Molecule

Description

1,2-Dibromo-3-chloropropane belongs to the organochlorides, a class of organohalogen compounds within the organic compounds. With the formula C3H5Br2Cl and an average molecular weight of 236.33 g/mol, this exogenous compound is a liquid at room temperature. It has been used as an industrial pesticide (PMC7807371). Exposure can occur through inhalation, oral intake, or touch. The compound has been released from 26 recorded sources, including drinking water and water supply (bottled, tap, desalinated, and drinking water), aquatic systems and sediments (freshwater, seawater, surface water, and groundwater), wastewater, sanitation and biosolids (unspecified wastewater, mine wastewater, wastewater treatment effluent, and industrial wastewater), appliances and HVAC and refrigerants (water heaters and water coolers), marine, shipping and aquaculture (bilge water and ballast water), and electrical and electronic equipment (hybrid capacitors, amplifiers, thin magnetic films, and conductors or conductive bodies characterised by the conductive materials). This organochloride targets 47 recorded proteins. It antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) at GABA-A receptors, blocking GABA-induced chloride ion uptake and causing central nervous system hyperexcitability. It inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, leading to intracellular free calcium ion accumulation, which promotes neurotransmitter release from storage vesicles, depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. It causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. Testicular toxicity is linked to the inhibition of sperm carbohydrate metabolism at the step of NADH dehydrogenase activity in the mitochondrial electron transport chain or direct DNA damage. Hepatotoxicity and nephrotoxicity may result from the initial metabolism of the compound into reactive epoxide metabolites that bind to DNA and other macromolecules. Health effects include infertility (PMC7173497), male infertility (PMC11432267), azoospermia (PMC10841502), and an increase in cancer (PMC11380803).

Contaminant Type

Bromide Compound
Organic Compound
Organobromide
Organochloride
PMT
Pesticide
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
DBCP	Kegg
Fumazone	MeSH
Nemagon	MeSH
Dibromochloropropane	MeSH

Chemical Formula

C₃H₅Br₂Cl

Average Molecular Mass

236.333 g/mol

Monoisotopic Mass

233.845 g/mol

CAS Registry Number

96-12-8

IUPAC Name

1,2-dibromo-3-chloropropane

Traditional Name

1,2-dibromo-3-chloropropane

SMILES

ClCC(Br)CBr

InChI Identifier

InChI=1S/C3H5Br2Cl/c4-1-3(5)2-6/h3H,1-2H2

InChI Key

WBEJYOJJBDISQU-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as organochlorides. Organochlorides are compounds containing a chemical bond between a carbon atom and a chlorine atom.

Kingdom

Organic compounds

Super Class

Organohalogen compounds

Class

Organochlorides

Sub Class

Not Available

Direct Parent

Organochlorides

Alternative Parents

Substituents

Hydrocarbon derivative
Organochloride
Organobromide
Alkyl halide
Alkyl chloride
Alkyl bromide
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

organochlorine compound (CHEBI:34044 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytosol
Membrane
Microsome
Mitochondrion

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Liquid

Appearance

Colorless liquid.

Experimental Properties

Property	Value
Melting Point	6°C
Boiling Point	Not Available
Solubility	1.23 mg/mL at 20 °C [MUNNECKE,DE & VANGUNDY,SD (1979)]

Predicted Properties

Property	Value	Source
Water Solubility	0.18 g/L	ALOGPS
logP	2.95	ALOGPS
logP	2.6	ChemAxon
logS	-3.1	ALOGPS
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	35.64 m³·mol⁻¹	ChemAxon
Polarizability	14.5 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0190000000-f0bca5ddedb90e7a3148	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0190000000-7d23b3a37f8710b52434	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0uea-2900000000-c9c1099b64d41ad21084	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0290000000-56143355a779c964900f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000t-0930000000-772ba1158fddcd576fe0	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udj-1900000000-6c76a8263e2e1b3e0cde	Not Available	View Spectrum
MS	MS Spectrum	splash10-0a6r-9800000000-7431833bc5f35bfd0c4b	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

The initial metabolism of 1,2-dibromo-3-chloropropane to reactive epoxide metabolites that bind to DNA and other macromolecules may be responsible for its hepatotoxicity and nephrotoxicity. The mechanism of 1,2-dibromo-3-chloropropane's testicular toxicity is believed to be due to either the inhibition of sperm carbohydrate metabolism, probably at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain, or drect DNA damage caused by its metabolites. (2, 1)

Carcinogenicity (IARC Classification)

2B, possibly carcinogenic to humans. (5)

Minimum Risk Level

Intermediate Inhalation: 0.0002 ppm (4) Intermediate Oral: 0.002 mg/kg/day (4)

Symptoms

Symptoms of 1,2-dibromo-3-chloropropane exposure include headaches, nausea, lightheadedness, and weakness. (2)

Treatment

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
100.0	mg/kg	Not Available	Rabbit	LD50	Oral	experimental	T25
1480.0	mg/m3	Not Available	Rat	LC50	Inhalation (1 hour)	experimental	T25

Health Effects

Health Effect	Relationship	Direction	Reference
cancer	associated_with	increase	PMC11380803
infertility	associated_with	Not Available	PMC7173497
male infertility	associated_with	Not Available	PMC11432267
azoospermia	associated_with	Not Available	PMC10841502
oligospermia	associated_with	Not Available	PMC10841502

Exposure Sources

Source ID	Source	Sector	Reference
3	Irrigation water	Agriculture & land management	Not Available
10	Insecticides	Agriculture & land management	Not Available
27	Water Coolers	Appliances, HVAC & refrigerants	Not Available
43	Water heaters	Appliances, HVAC & refrigerants	Not Available
50	Groundwater	Aquatic systems & sediments	Not Available
51	Surface water	Aquatic systems & sediments	Not Available
52	Seawater	Aquatic systems & sediments	Not Available
53	Freshwater	Aquatic systems & sediments	Not Available
70	Stormwater runoff	Automotive & urban infrastructure	Not Available
88	Waterproofing sprays	Building & Construction	Not Available
115	Drinking water	Drinking water & water supply	Not Available
116	Tap water	Drinking water & water supply	Not Available
117	Bottled water	Drinking water & water supply	Not Available
118	Desalinated water	Drinking water & water supply	Not Available
181	Ballast water	Marine, shipping & aquaculture	Not Available
182	Bilge water	Marine, shipping & aquaculture	Not Available
468	Industrial wastewater	Wastewater, sanitation & biosolids	Not Available
470	Wastewater treatment effluent	Wastewater, sanitation & biosolids	Not Available
475	Mine wastewater	Wastewater, sanitation & biosolids	Not Available
477	Wastewater, unspecified	Wastewater, sanitation & biosolids	Not Available
505	Amplifiers	Electrical & Electronic Equipment	Not Available
511	Conductors Or Conductive Bodies Characterised By The Conductive Materials	Electrical & Electronic Equipment	Not Available
524	Hybrid Capacitors	Electrical & Electronic Equipment	Not Available
538	Thin Magnetic Films	Electrical & Electronic Equipment	Not Available
545	Food Preservation	Food, food processing & cookware	Not Available
561	Perfumes Within Detergents And Soaps	Household cleaning & consumer products	Not Available
563	Soap Detergents	Household cleaning & consumer products	Not Available
580	Manufacture Preparation Of Tobacco Products	Industrial manufacturing & chemical processing	Not Available
583	Anchoring Equipment	Marine, shipping & aquaculture	Not Available
584	Buoys	Marine, shipping & aquaculture	Not Available
596	Acaricides	Agriculture & land management	Not Available
597	Chemosterilants	Agriculture & land management	Not Available
600	Herbicides And Algicides	Agriculture & land management	Not Available
602	Molluscicides	Agriculture & land management	Not Available
603	Nematocides	Agriculture & land management	Not Available
604	Pest Attractants	Agriculture & land management	Not Available
605	Pest Repellants	Agriculture & land management	Not Available
606	Plant Growth Regulators	Agriculture & land management	Not Available
607	Rodenticides(1)	Agriculture & land management	Not Available
608	Rodenticides	Agriculture & land management	Not Available
618	Lip Makeup Products	Personal care & cosmetics	Not Available
652	Ropes	Textiles, leather & furnishings	Not Available

Pathways

1 pathway

Apoptosis

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	3-ketoacyl-CoA synthase 20	Q9FG87	Arabidopsis thaliana	Predicted (SEA)	167.22
Click to view 3D structure	Putative agmatine deiminase	Q8DW17	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	Predicted (SEA)	296.138
Click to view 3D structure	Actin nucleation-promoting factor WASL	O08816	Rattus norvegicus	Predicted (SEA)	3230.74
Click to view 3D structure	Palmitoyltransferase ZDHHC7	Q9NXF8	Humans	Predicted (SEA)	1361.74
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Predicted (SEA)	7784.46
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	7784.22
Click to view 3D structure	Protein RecA	P9WHJ3	Mycobacterium tuberculosis	Predicted (SEA)	7782.9
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	7784.3
Click to view 3D structure	Phospho-2-dehydro-3-deoxyheptonate aldolase	C3TIE2	Escherichia coli	Predicted (SEA)	1010.17
Click to view 3D structure	Replicase polyprotein 1ab	P0DTD1	SARS-CoV-2	Predicted (SEA)	7784.38
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P08909	Rat	Predicted (SEA)	7783.37
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	7784.61
Click to view 3D structure	Phospholipase B	Q9P8P2	Cryptococcus neoformans	Predicted (SEA)	262.508
Click to view 3D structure	Beta-lactamase VIM-1	Q9XAY4	Pseudomonas aeruginosa	Predicted (SEA)	1175.21
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	7784.14
Click to view 3D structure	Retinal dehydrogenase 2	O93344	Gallus gallus	Predicted (SEA)	2281.06
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	7784.61
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P30994	Rattus norvegicus	Predicted (SEA)	7772.0
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	7784.61
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P14842	Rattus norvegicus	Predicted (SEA)	7784.22
Click to view 3D structure	Sodium-dependent dopamine transporter	P23977	Rattus norvegicus	Predicted (SEA)	7784.22
Click to view 3D structure	Asc-type amino acid transporter 1	P63116	Rat	Predicted (SEA)	1737.75
Click to view 3D structure	Serotonin N-acetyltransferase	Q16613	Humans	Predicted (SEA)	6534.12
Click to view 3D structure	Tyrosine-protein kinase Lck	P06239	Humans	Predicted (SEA)	7784.53
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	7784.53
Click to view 3D structure	Estrogen receptor	P03372	Humans	Known	Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (A590)
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Known	Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (A590)
Click to view 3D structure	Calcium-transporting ATPase type 2C member 1	P98194	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-2	P47869	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-3	P34903	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-4	P48169	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-5	P31644	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit alpha-6	Q16445	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-1	P18505	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit beta-2	P47870	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit delta	O14764	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit epsilon	P78334	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-1	Q8N1C3	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit gamma-3	Q99928	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit pi	O00591	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-1	P24046	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-2	P28476	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit rho-3	A8MPY1	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	Gamma-aminobutyric acid receptor subunit theta	Q9UN88	Humans	Known	This organochloride antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. (T10)
Click to view 3D structure	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	P49821	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	P19404	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	P56181	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	O75306	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	O75489	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	O43181	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	O43920	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	O75380	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	O75251	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	O00217	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	P28331	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 1	P03886	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 2	P03891	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 3	P03897	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 4	P03905	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 4L	P03901	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 5	P03915	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	NADH-ubiquinone oxidoreductase chain 6	P03923	Humans	Known	Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity.
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	O14983	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P16615	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-1	P05023	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-2	P50993	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-3	P13637	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-4	Q13733	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-1	P05026	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-2	P14415	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-3	P54709	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit gamma	P54710	Humans	Known	This organochloride inhibits Na+/K+ ATPase and Ca2+ and Mg2+ ATPase, which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. (T10)