Carbon disulfide (CED0001147)

Carbon disulfide (CS2) is a liquid at room temperature with an average molecular weight of 76.14 g/mol. Carbon disulfide belongs to the other non-metal sulfides, a subclass of other non-metal organides within the inorganic compounds. This exogenous compound is released from 48 recorded sources, including electrical and electronic equipment such as amplifiers, antennas, auxiliary devices, adjustable resistors, and colour television systems. It is also found in household cleaning and consumer products, including bleaching agents, perfumes within detergents and soaps, cigar cigarettes, other smoking requisites, and non electric simulated smoking devices. Additional sources include food, food processing and cookware—specifically food contact materials, food preservation, the preparation of malt, the preparation of wine or sparkling wine, and fermentation processes for beer—as well as building and construction materials such as floors, ceilings, roofs, stairs and ramps, and ladders. It is released in polyethylene terephthalate plastics. Recorded exposure routes include oral, touch, and inhalation (PMC9202949). Carbon disulfide inhibits the protein targets cytochrome P450 1A1 (CYP1A1) and cytochrome P450 2E1 (CYP2E1). It also inhibits dopamine beta-hydroxylase (DBH); it is hypothesized that this occurs via the formation of dithiocarbamate metabolites which bind to enzymic copper, as CS2 can react with endogenous amines. Exposure to carbon disulfide is associated with blood pressure (PMC9202949).