1,4-Dioxane (CED0002622)

1,4-Dioxane (C4H8O2) is an exogenous organic compound with an average molecular weight of 88.11 g/mol that exists as a liquid at room temperature. 1,4-Dioxane belongs to the 1,4-dioxanes, a subclass of dioxanes within the organic compounds. This compound is classified as a superclass organoheterocyclic compound. It serves as an industrial solvent (PMC11733951, PMC8880212, PMC9056551), industrial stabilizer (PMC8633123), surfactant, and fragrance, as well as a non-polar chemical solvent. Biologically, it is identified as a carcinogenic agent. Exposure to 1,4-Dioxane occurs through oral, touch, and inhalation routes, with literature support specifically for inhalation (PMC13303702). It has been recorded in 46 sources, including drinking water, tap water, bottled water, and desalinated water. It is also found in aquatic systems such as groundwater, surface water, seawater, and freshwater, as well as in wastewater, industrial wastewater, and wastewater treatment effluent. Other sources include food contact materials, fermentation processes for beer, preparation of malt, preparation of wine or sparkling wine, and processing meats. It is also present in household cleaning and consumer products like soap dispensers and bleaching agents, and in electrical and electronic equipment including amplifiers, antennas, communication cables or conductors, and auxiliary devices. The compound is associated with cancer (PMC10005944, PMC9835328). Six protein targets have been recorded for 1,4-Dioxane, including Epsin-1 (EPN1), Tumor necrosis factor ligand superfamily member 13B (TNFSF13B), Transforming growth factor beta-3 proprotein (TGFB3), and Transient receptor potential cation channel subfamily A member 1 (TRPA1).