Cadmium sulphide (CED0004888)

Record Information
Version1.0
Creation Date2009-03-06 18:58:40 UTC
Update Date2026-08-26 00:10:21 UTC
Accession NumberCHEM000329
Identification
Common NameCadmium sulphide
ClassSmall Molecule
Description
Cadmium sulphide is an exogenous inorganic compound with the formula CdH2S and an average molecular weight of 146.49 g/mol. It exists as a solid at room temperature. Cadmium sulphide belongs to the transition metal sulfides, a subclass of transition metal organides within the inorganic compounds. It is primarily used as a pigment and a semiconductor. The compound is found in or released from 45 recorded sources. These include household items such as key rings, and household cleaning and consumer products including soap dispensers, soap detergents, bleaching agents, cigar cigarettes, and non-electric simulated smoking devices. In the building and construction sector, it is associated with ceilings, fencing, roofs, stairs and ramps, and sunshades awnings or outside screens. It is also present in electrical and electronic equipment, such as amplifiers, antennas, coils, and adjustable resistors, among 23 others. Additionally, it is linked to food processing and cookware, specifically cellar tools, the processing of meats, the preparation of vinegar, and fermentation processes for beer. Cadmium sulphide interacts with 12 recorded protein targets. It activates mitogen-activated protein kinases, including MAPK1, MAPK3, MAPK8, and MAPK10, which causes cell apoptosis. Furthermore, it binds to and activates the estrogen receptor beta (ESR2) and estrogen receptor (ESR1). This activity likely causes reproductive dysfunction and stimulates the growth of certain types of cancer cells through other estrogenic effects.
Contaminant Type
  • Cadmium Compound
  • Household Toxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Natural Compound
  • Pollutant
Chemical Structure
Synonyms
ValueSource
Cadmium sulphaneGenerator
Chemical FormulaCdH2S
Average Molecular Mass146.490 g/mol
Monoisotopic Mass147.891 g/mol
CAS Registry Number1306-23-6
IUPAC Namecadmium sulfane
Traditional Namecadmium sulfane
SMILESS.[Cd]
InChI IdentifierInChI=1S/Cd.H2S/h;1H2
InChI KeyBBBXWHWGTUXPKK-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as transition metal sulfides. These are inorganic compounds containing a sulfur atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a transition metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassTransition metal organides
Sub ClassTransition metal sulfides
Direct ParentTransition metal sulfides
Alternative Parents
Substituents
  • Transition metal sulfide
  • Inorganic cadmium salt
  • Inorganic sulfide
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateSolid
AppearanceLight yellow, orange or brown crystals.
Experimental Properties
PropertyValue
Melting Point1750°C at 100 bar (10 MPa)
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
Water Solubility152 g/LALOGPS
logP-1.3ALOGPS
logP-0.07ChemAxon
logS0.02ALOGPS
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyDeposition DateView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-0900000000-6ed3cf6091ee4954477eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-0900000000-6ed3cf6091ee4954477eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-0900000000-6ed3cf6091ee4954477eNot AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-0900000000-9a52bacf583aa62ab185Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-0900000000-9a52bacf583aa62ab185Not AvailableView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrumsplash10-0002-0900000000-9a52bacf583aa62ab185Not AvailableView Spectrum
Toxicity Profile
Mechanism of ToxicityCadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available metallothionein, and it has also been shown that the cadmium-metallothionein complex may be damaging. Accumulation of cadmium in the kidney results in increased excretion of vital low and high weight molecular proteins. Cadmium is a high affinity zinc analog and can interfere in its biological processes. It also binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. Cadmium causes cell apoptosis by activating mitogen-activated protein kinases. (5, 1, 2, 3)
Carcinogenicity (IARC Classification)1, carcinogenic to humans. (8)
Minimum Risk LevelAcute Inhalation: 0.00003 mg/m3 (7) Chronic Inhalation: 0.00001 mg/m3 (7) Intermediate Oral: 0.0005 mg/kg/day (7) Chronic Oral: 0.0001 mg/kg/day (7)
SymptomsAcute inhalation of cadmium fumes results in metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Ingestion of cadmium causes vomiting and diarrhea. (4)
TreatmentCadmium poisoning is treated by removal from exposure and supportive care. If ingested, induced vomiting or gastric lavage may be performed. (9)
Toxicity Values
Toxicity ValueUnitValue RangeOrganismDose DescriptorRoute of ExposurePredicted or ExperimentalReference
1166.0mg/kgNot AvailableMouseLD50OralexperimentalT14
Health Effects
Health EffectRelationshipDirectionReference
Exposure Sources
Source IDSourceSectorReference
10InsecticidesAgriculture & land managementNot Available
233BrushesPersonal care & cosmeticsNot Available
495CeilingsBuilding & ConstructionNot Available
496FencingBuilding & ConstructionNot Available
499RoofsBuilding & ConstructionNot Available
500Stairs And RampsBuilding & ConstructionNot Available
501Sunshades Awnings Or Outside ScreensBuilding & ConstructionNot Available
502Sunshades Awnings Or Outside ScreensBuilding & ConstructionNot Available
504Adjustable ResistorsElectrical & Electronic EquipmentNot Available
505AmplifiersElectrical & Electronic EquipmentNot Available
506AntennasElectrical & Electronic EquipmentNot Available
507Auxiliary DevicesElectrical & Electronic EquipmentNot Available
508CoilsElectrical & Electronic EquipmentNot Available
509Colour Television SystemsElectrical & Electronic EquipmentNot Available
510Communication Cables Or ConductorsElectrical & Electronic EquipmentNot Available
513Cores Yokes Or ArmaturesElectrical & Electronic EquipmentNot Available
514Discharge LampsElectrical & Electronic EquipmentNot Available
516Electric Hearing AidsElectrical & Electronic EquipmentNot Available
517Electric SwitchesElectrical & Electronic EquipmentNot Available
518Electrically Stimulated Smoking DevicesElectrical & Electronic EquipmentNot Available
520Emergency Protective DevicesElectrical & Electronic EquipmentNot Available
521Fixed Capacitors And Their ManufactureElectrical & Electronic EquipmentNot Available
523Gas Filled Discharge Tubes With Solid CathodeElectrical & Electronic EquipmentNot Available
524Hybrid CapacitorsElectrical & Electronic EquipmentNot Available
525Line Transmission SystemsElectrical & Electronic EquipmentNot Available
526LoudspeakersElectrical & Electronic EquipmentNot Available
527MagnetsElectrical & Electronic EquipmentNot Available
529Power CablesElectrical & Electronic EquipmentNot Available
530Radio Transmission SystemsElectrical & Electronic EquipmentNot Available
531RelaysElectrical & Electronic EquipmentNot Available
533Sparking PlugsElectrical & Electronic EquipmentNot Available
534Still Video CamerasElectrical & Electronic EquipmentNot Available
537Television SystemsElectrical & Electronic EquipmentNot Available
538Thin Magnetic FilmsElectrical & Electronic EquipmentNot Available
539Video GamesElectrical & Electronic EquipmentNot Available
540X Ray TubesElectrical & Electronic EquipmentNot Available
543Cellar ToolsFood, food processing & cookwareNot Available
544Fermentation Processes For BeerFood, food processing & cookwareNot Available
548Preparation Of VinegarFood, food processing & cookwareNot Available
552Processing MeatsFood, food processing & cookwareNot Available
555Bleaching AgentsHousehold cleaning & consumer productsNot Available
556Cigar CigarettesHousehold cleaning & consumer productsNot Available
559Non Electric Simulated Smoking DevicesHousehold cleaning & consumer productsNot Available
563Soap DetergentsHousehold cleaning & consumer productsNot Available
564Soap DispensersHousehold cleaning & consumer productsNot Available
569Tobacco Smoke FiltersHousehold cleaning & consumer productsNot Available
573Key RingsHousehold itemsNot Available
579Manufacture Of Iron Or SteelIndustrial manufacturing & chemical processingNot Available
580Manufacture Preparation Of Tobacco ProductsIndustrial manufacturing & chemical processingNot Available
581Paper Making MachinesIndustrial manufacturing & chemical processingNot Available
583Anchoring EquipmentMarine, shipping & aquacultureNot Available
584BuoysMarine, shipping & aquacultureNot Available
592Marine Propulsion Or SteeringMarine, shipping & aquacultureNot Available
596AcaricidesAgriculture & land managementNot Available
600Herbicides And AlgicidesAgriculture & land managementNot Available
603NematocidesAgriculture & land managementNot Available
605Pest RepellantsAgriculture & land managementNot Available
606Plant Growth RegulatorsAgriculture & land managementNot Available
613DepilatoriesPersonal care & cosmeticsNot Available
614Essential Oils Or PerfumesPersonal care & cosmeticsNot Available
615Eye Makeup ProductsPersonal care & cosmeticsNot Available
617Lip Care ProductsPersonal care & cosmeticsNot Available
618Lip Makeup ProductsPersonal care & cosmeticsNot Available
619Manicure PedicurePersonal care & cosmeticsNot Available
620Card GamesRecreation & sports surfacesNot Available
624Merry Go RoundsRecreation & sports surfacesNot Available
630ToysRecreation & sports surfacesNot Available
633Azo DyesTextiles, leather & furnishingsNot Available
634BucklesTextiles, leather & furnishingsNot Available
635ButtonsTextiles, leather & furnishingsNot Available
638Decorating TextilesTextiles, leather & furnishingsNot Available
640Embroidering And TuftingTextiles, leather & furnishingsNot Available
642FootwearTextiles, leather & furnishingsNot Available
643HeadwearTextiles, leather & furnishingsNot Available
647Multicolour DyeingTextiles, leather & furnishingsNot Available
650Purses Luggage Hand BagsTextiles, leather & furnishingsNot Available
652RopesTextiles, leather & furnishingsNot Available
653SewingTextiles, leather & furnishingsNot Available
655Slide FastenersTextiles, leather & furnishingsNot Available
656Snap FastenersTextiles, leather & furnishingsNot Available
657Surface Finishing Of LeatherTextiles, leather & furnishingsNot Available
658Touch FastenersTextiles, leather & furnishingsNot Available
659Transfer PrintingTextiles, leather & furnishingsNot Available
662Yarns Or ThreadsTextiles, leather & furnishingsNot Available
Pathways
0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
C-Jun-amino-terminal kinase-interacting protein 1 structureClick to view 3D structureC-Jun-amino-terminal kinase-interacting protein 1Q9UQF2HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Estrogen receptor structureClick to view 3D structureEstrogen receptorP03372HumansKnownCadmium binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. (A19)
Estrogen receptor beta structureClick to view 3D structureEstrogen receptor betaQ92731HumansKnownCadmium binds to and activates the estrogen receptor, likely stimulating the growth of certain types of cancer cells and causing other estrogenic effects, such as reproductive dysfunction. (A19)
Mitogen-activated protein kinase 1 structureClick to view 3D structureMitogen-activated protein kinase 1P28482HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 10 structureClick to view 3D structureMitogen-activated protein kinase 10P53779HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 11 structureClick to view 3D structureMitogen-activated protein kinase 11Q15759HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 12 structureClick to view 3D structureMitogen-activated protein kinase 12P53778HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 13 structureClick to view 3D structureMitogen-activated protein kinase 13O15264HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 14 structureClick to view 3D structureMitogen-activated protein kinase 14Q16539HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 3 structureClick to view 3D structureMitogen-activated protein kinase 3P27361HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 8 structureClick to view 3D structureMitogen-activated protein kinase 8P45983HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Mitogen-activated protein kinase 9 structureClick to view 3D structureMitogen-activated protein kinase 9P45984HumansKnownCadmium causes cell apoptosis by activating mitogen-activated protein kinases. (A28)
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkNot Available
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound ID20975638
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References