Bisphenol A (CED0001565)

Record Information

Version

1.0

Creation Date

2009-03-19 21:46:58 UTC

Update Date

2026-05-14 18:29:24 UTC

Accession Number

CHEM000566

Identification

Common Name

Bisphenol A

Class

Small Molecule

Description

Bisphenol A (C15H16O2) is an exogenous organic compound with an average molecular weight of 228.29 g/mol. It exists as a solid at room temperature. Bisphenol A belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. Industrially, it is used as a catalyst (PMC11381038), additive (PMC13025183), stabilizer (PMC4018667), antioxidant (PMC4018667), and fungicide (PMC5588144), as well as a flame retardant (PMC5588144). It is present in high-density polyethylene and used in polyurethane, polyvinyl chloride, acrylonitrile butadiene styrene, and low-density polyethylene. It is released from polycarbonate, polyamide, polystyrene, polypropylene, and polyethylene terephthalate. Biologically, it acts as an estrogen (PMC5505257), xenoestrogen (PMC11105698), agonist (PMC10253990), inhibitor (PMC4452124), electron donor (PMC10624391), toxin (PMC9457803), and endocrine disruptor (PMC10043879, PMC13347373). It is an environmental contaminant (PMC8130848) and phenol (PMC9518589). It targets several proteins, including the estrogen receptors ESR1 and ESR2, the androgen receptor AR, and the estrogen-related receptor gamma (ESRRG). It also competitively inhibits the binding of L-T3 and 17beta-estradiol to protein disulfide-isomerase (P4HB). Exposure occurs via touch, oral, and inhalation routes (PMC10047534, PMC11546519, PMC3419714, PMC6024920, PMC6098722, PMC6370520, PMC9098901). Sources include drinking water, aquatic systems, food contact materials, building and construction materials, and electrical equipment. Health effects associated with bisphenol A include cancer (PMC10139116, PMC12758521, PMC6625918, PMC7766742, PMC8151977, PMC8395949, PMC8746877, PMC9300791), specifically breast cancer (PMC10314155, PMC11755457, PMC12320938, PMC13064397, PMC8834979, PMC11873108, PMC11938062, PMC12573425, PMC12649852, PMC13179207, PMC5458606, PMC5521805, PMC7064327), colorectal cancer (PMC13064397), endometrial cancer (PMC10720226, PMC6891210), and ovarian cancer (PMC11479995). It is linked to prostate cancer (PMC10938891, PMC11357130, PMC2072856), though some data suggests a decrease (PMC11613181, PMC12573425, PMC3458140). Other associations include obesity (PMC10048338, PMC10226345, PMC10314155, PMC10596897, PMC10831155, PMC10938891, PMC11277516, PMC11443065), infertility (PMC10139116, PMC10612124, PMC10831155, PMC10938891, PMC4562201, PMC8151977), male infertility (PMC10261808, PMC13193906), polycystic ovary syndrome (PMC10938891, PMC11479995), endometriosis (PMC13179207), hypertension (PMC12284880, PMC4985394, PMC7684853, PMC9921712), increased blood pressure (PMC12875064, PMC7354351), stroke (PMC10946040), atherosclerosis (PMC9469194), coronary artery disease (PMC12875064), chronic kidney disease (PMC12829686), inflammation (PMC11319549, PMC6397216), and asthma (PMC12501166, PMC12537159, PMC9918139), though some reports indicate a decrease (PMC12321497, PMC7722407).

Contaminant Type

Aromatic Hydrocarbon
Food Toxin
Household Toxin
Human Neurotoxin
Industrial/Workplace Toxin
Metabolite
Organic Compound
PMT
Pesticide
Phenolic Antioxidant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2, 2-Bis(4-hydroxyphenyl)propane	ChEBI
2,2-Bis(4'-hydroxyphenyl)propane	ChEBI
2,2-Bis(4-hydroxyphenyl)propane	ChEBI
2,2-Bis(p-hydroxyphenyl)propane	ChEBI
2,2-Di(4-hydroxyphenyl)propane	ChEBI
2,2-Di(4-phenylol)propane	ChEBI
4,4'-(1-Methylethane-1,1-diyl)diphenol	ChEBI
4,4'-(1-Methylethylidene)bisphenol	ChEBI
4,4'-(Propane-2,2-diyl)diphenol	ChEBI
4,4'-Bisphenol a	ChEBI
4,4'-Isopropylidenediphenol	ChEBI
Bisphenol-a	ChEBI
BPA	ChEBI
Dianin's compound	ChEBI
(1-Methylethylidene)bis-phenol	HMDB
1,1'-(1-Methylethylidene)bisphenylol, 9ci	HMDB
2, 2-Bis(hydroxyphenyl)propane	HMDB
2, 2-Di(4-phenylol)propane	HMDB
2,2'-Bis(4-hydroxyphenyl)propane	HMDB
2,2-(4,4'-Dihydroxydiphenyl)propane	HMDB
2,2-(4,4-Dihydroxydiphenyl)propane	HMDB
2,2-Bis (4-hydroxyphenol) propane	HMDB
2,2-Bis(4,4'-hydroxyphenyl)propane	HMDB
2,2-Bis(hydroxyphenyl)propane	HMDB
2,2-Bis(p-hydroxyphenyl)-propane	HMDB
2,2-Bis-4'-hydroxyfenylpropan	HMDB
2,2-Bis[4-hydroxyphenyl]propane	HMDB
2,2-Di-(4'-hydroxyphenyl)-propane	HMDB
4, 4'-Bisphenol a	HMDB
4, 4'-Dihydroxydiphenyl-2,2-propane	HMDB
4, 4'-Dihydroxydiphenyldimethylmethane	HMDB
4, 4'-Dihydroxydiphenylpropane	HMDB
4,4' Isopropylidinediphenol	HMDB
4,4'-(1-Methylethylidene)bis-phenol	HMDB
4,4'-(1-Methylethylidene)bisphenol, 9ci	HMDB
4,4'-Dihydroxdiphenylpropane	HMDB
4,4'-Dihydroxy-2,2-diphenylpropane	HMDB
4,4'-Dihydroxydiphenyl-2,2-propane	HMDB
4,4'-Dihydroxydiphenyldimethylmethane	HMDB
4,4'-Dihydroxydiphenylpropane	HMDB
4,4'-Dimethylmethylenedi-phenol	HMDB
4,4'-Dimethylmethylenediphenol	HMDB
4,4'-Isopropylidene diphenol	HMDB
4,4'-ISOPROPYLIDENE-diphenol	HMDB
4,4'-Isopropylidenebisphenol	HMDB
4,4'-Isopropylidenebis[phenol]	HMDB
4,4'-Isopropylidenedi-phenol	HMDB
4,4'-ISOPROPYLIDENEDIPHENOL (bisphenol a)	HMDB
4,4'-Isopropylidenediphenol b	HMDB
4,4'-Isopropylidenediphenol, 8ci	HMDB
4,4'-Propane-2,2-diyldiphenol	HMDB
4,4-Isopropylidenediphenol	HMDB
4,4[-Isopropylidenediphenol	HMDB
4-[1-(4-Hydroxyphenyl)-1-methylethyl]phenol	HMDB
beta, Beta'-bis(p-hydroxyphenyl)propane	HMDB
beta,Beta'-bis(p-hydroxyphenyl)propane	HMDB
beta,beta-Di-(p-hydroxyphenyl)propane	HMDB
beta-Di-(p-hydroxyphenyl)propane	HMDB
beta-Di-p-hydroxyphenylpropane	HMDB
Biphenol a	HMDB
Bis(4-hyd roxyphenyl) dimethylmethane	HMDB
Bis(4-hydroxyphenyl) dimethylmethane	HMDB
Bis(4-hydroxyphenyl) propane	HMDB
Bis(4-hydroxyphenyl)dimethylmethane	HMDB
Bis(4-hydroxyphenyl)propane	HMDB
Bis(p-hydroxyphenyl)propane	HMDB
Bisferol a	HMDB
Bisphenol	HMDB
Bisphenol a (bpa)	HMDB
Bisphenol a, disodium salt	HMDB
Bisphenol a, sodium salt	HMDB
Bisphenol a.	HMDB
Di-2,2-(4-hydroxyphenyl)propane	HMDB
Dian	HMDB
Diano	HMDB
Dimethyl bis(p-hydroxyphenyl)methane	HMDB
Dimethylbis(p-hydroxyphenyl)methane	HMDB
Dimethylmethylene-p,p'-diphenol	HMDB
Diphenylolpropane	HMDB
Hydrogenated bisphenol a	HMDB
Ipognox 88	HMDB
Isopropylidenebis(4-hydroxybenzene)	HMDB
Millad hbpa	HMDB
Noname	HMDB
p, P'-dihydroxydiphenyldimethylmethane	HMDB
p, P'-dihydroxydiphenylpropane	HMDB
p, P'-isopropylidenediphenol	HMDB
p,P'-bisphenol a	HMDB
p,P'-dihydroxydiphenyldimethylmethane	HMDB
p,P'-dihydroxydiphenylpropane	HMDB
p,P'-isopropylidenebisphenol	HMDB
p,P'-isopropylidenediphenol	HMDB
Parabis	HMDB
Parabis a	HMDB
Poly(bisphenol a carbonate)	HMDB
Rikabanol	HMDB
Ucar bisphenol a	HMDB
Ucar bisphenol HP	HMDB

Chemical Formula

C₁₅H₁₆O₂

Average Molecular Mass

228.286 g/mol

Monoisotopic Mass

228.115 g/mol

CAS Registry Number

1980-05-07

IUPAC Name

4-[2-(4-hydroxyphenyl)propan-2-yl]phenol

Traditional Name

bisphenol-A

SMILES

CC(C)(C1=CC=C(O)C=C1)C1=CC=C(O)C=C1

InChI Identifier

InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3

InChI Key

IISBACLAFKSPIT-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as bisphenols. These are methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone).

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Diphenylmethanes

Direct Parent

Bisphenols

Alternative Parents

Substituents

Bisphenol
Phenylpropane
1-hydroxy-2-unsubstituted benzenoid
Phenol
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

bisphenol (CHEBI:33216 )
Bisphenols (C13624 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

Crystallizes as prisms from dil acetic acid and as needles from water (3).

Experimental Properties

Property	Value
Melting Point	156 - 157°C
Boiling Point	Not Available
Solubility	0.12 mg/mL at 25°C

Predicted Properties

Property	Value	Source
Water Solubility	0.086 g/L	ALOGPS
logP	3.81	ALOGPS
logP	4.04	ChemAxon
logS	-3.4	ALOGPS
pKa (Strongest Acidic)	9.78	ChemAxon
pKa (Strongest Basic)	-5.5	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	40.46 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	79.28 m³·mol⁻¹	ChemAxon
Polarizability	25.41 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
GC-MS	GC-MS Spectrum	splash10-03di-2290000000-5a53b16778a578ff5d0d	Not Available	View Spectrum
GC-MS	GC-MS Spectrum	splash10-03di-2290000000-5a53b16778a578ff5d0d	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-03g0-1790000000-7521406d051aed77fe2f	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-0ab9-6289000000-59b1fac0d66836445629	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0zfs-4960000000-b4ebb7f1ff08fbb41adb	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-004i-1090000000-80a2709d727e93053cd1	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-004i-0090000000-c33246c7d9d8b300c90c	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-004i-0090000000-e5f7d4cb43ef56a85056	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0532-9340000000-c3298310f84ad87b1310	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000t-9000000000-75784b9156574d6f1762	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0a4j-1900000000-1316f0a328865698ba14	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-000t-9000000000-75784b9156574d6f1762	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0zfs-4960000000-b4ebb7f1ff08fbb41adb	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-004i-0090000000-c33246c7d9d8b300c90c	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-004i-1090000000-80a2709d727e93053cd1	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-004i-0090000000-e5f7d4cb43ef56a85056	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0532-9340000000-c3298310f84ad87b1310	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-0a4j-1900000000-1316f0a328865698ba14	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0090000000-8791a2cf0310bf33a81e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0190000000-ee807d7dec5640d38d18	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-01rb-2920000000-e15c6a1d966dd429fe3f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0090000000-0494eb6f9068e16e1d99	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0090000000-e9b5452c25e607f29950	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-002f-9470000000-9d3d569c0a3f755f123f	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-002r-1960000000-42e45d340eea8ee9e3db	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-3900000000-8ef860db11d71a8b2f2e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-2900000000-61ebc2c60a263652b43e	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-3090000000-27243d7aedeaef4a196c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0095-3940000000-3863b01420a8ec7c47d3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00lu-3900000000-4783970c45944f22eac3	Not Available	View Spectrum
MS	MS Spectrum	splash10-03di-3590000000-0cd99fd08fc2fad698f3	Not Available	View Spectrum

Toxicity Profile

Mechanism of Toxicity

Bisphenol is an endocrine disruptor. Low doses of bisphenol A can mimic the body's own hormones, possibly causing negative health effects. There is thus concern that long term low dose exposure to bisphenol A may induce chronic toxicity in humans (6).

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Bisphenol A has low acute toxicity, with an oral LD50 of 3250 mg/kg in rats, but it is an endocrine disruptor. Low doses of bisphenol A can mimic the body's own hormones, possibly causing negative health effects. There is thus concern that long term low dose exposure to bisphenol A may induce chronic toxicity in humans. (7)

Treatment

Consider dilution immediately after ingestion. Insertion of a specialized nasogastric tube after confirmation of a circumferential burn may prevent strictures. In case of inhalation, move patient to fresh air and monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. In case of eye contact, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Decontaminate skin or mucous membranes immediately with water and a soft sponge. (8)

Toxicity Values

Toxicity Value	Unit	Value Range	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Reference
2230.0	mg/kg	Not Available	Rabbit	LD50	Oral	experimental	T249
1484.0	Log mg/kg	[830:2600]	Rat	LD50	oral	predicted	Not Available

Health Effects

Health Effect	Relationship	Direction	Reference
hypertension	associated_with	Not Available	PMC12284880 , PMC4985394 , PMC7684853 , PMC9921712
hypertension	elevated_in_urine_in	increase	PMC12127655
blood pressure	associated_with	increase	PMC12875064 , PMC7354351
inflammation	associated_with	Not Available	PMC11319549 , PMC6397216
cancer	associated_with	Not Available	PMC10139116 , PMC12758521 , PMC6625918 , PMC7766742 , PMC8151977 , PMC8395949 , PMC8746877 , PMC9300791
breast cancer	associated_with	increase	PMC10314155 , PMC11755457 , PMC12320938 , PMC13064397 , PMC8834979
breast cancer	associated_with	Not Available	PMC11755457 , PMC11873108 , PMC11873108 , PMC11938062 , PMC12573425 , PMC12649852 , PMC13179207 , PMC5458606 , PMC5521805 , PMC7064327
type 2 diabetes mellitus	associated_with	Not Available	PMC4069068
overweight	associated_with	Not Available	PMC8632231
colorectal cancer	associated_with	Not Available	PMC13064397
infertility	associated_with	Not Available	PMC10139116 , PMC10612124 , PMC10831155 , PMC10938891 , PMC4562201 , PMC4562201 , PMC8151977
polycystic ovary syndrome	associated_with	Not Available	PMC10938891 , PMC11479995
asthma	associated_with	decrease	PMC12321497 , PMC7722407
asthma	associated_with	Not Available	PMC12501166 , PMC12537159 , PMC9918139
asthma	elevated_in_blood_in	increase	PMC13272424
stroke	associated_with	increase	PMC10946040
endometrial cancer	associated_with	increase	PMC10720226 , PMC6891210
weight gain	associated_with	Not Available	PMC10226345 , PMC3005328 , PMC3295349 , PMC3384466
Prostate cancer	associated_with	Not Available	PMC10938891 , PMC11357130 , PMC2072856
Prostate cancer	associated_with	decrease	PMC11613181 , PMC12573425 , PMC3458140
colon cancer	associated_with	Not Available	PMC10052295
anxiety	associated_with	Not Available	PMC7384796
depression	associated_with	Not Available	PMC10825434 , PMC11938062
obesity	associated_with	Not Available	PMC10048338 , PMC10048338 , PMC10226345 , PMC10226345 , PMC10314155 , PMC10596897 , PMC10831155 , PMC10938891 , PMC11277516 , PMC11443065
obesity	associated_with	increase	PMC9649566
atherosclerosis	associated_with	increase	PMC9469194
lymphoma	has_therapeutic_effect_on	Not Available	PMC6300865
chronic kidney disease	associated_with	Not Available	PMC12829686
myocardial infarction	elevated_in_urine_in	increase	PMC12127655
heart disease	associated_with	Not Available	PMC10314155
male infertility	associated_with	Not Available	PMC10261808 , PMC13193906
ovarian cancer	associated_with	increase	PMC11479995
coronary artery disease	associated_with	Not Available	PMC12875064
coronary artery disease	elevated_in_urine_in	increase	PMC12127655
Endometriosis	associated_with	Not Available	PMC13179207
ovarian dysfunction	associated_with	Not Available	PMC9675081
breast	associated_with	Not Available	PMC10938891
hyperactivity	associated_with	Not Available	PMC7384796
attention deficit hyperactivity disorder	associated_with	Not Available	PMC11348251
cryptorchidism	elevated_in_blood_in	Not Available	PMC8654277
autoimmune disease	associated_with	Not Available	PMC7644792
anxiety disorder	associated_with	Not Available	PMC12525116

Exposure Sources

Source ID	Source	Sector	Reference
3	Irrigation water	Agriculture & land management	Not Available
10	Insecticides	Agriculture & land management	Not Available
19	Indoor air	Air, dust & atmospheric transport	Not Available
27	Water Coolers	Appliances, HVAC & refrigerants	Not Available
43	Water heaters	Appliances, HVAC & refrigerants	Not Available
50	Groundwater	Aquatic systems & sediments	Not Available
51	Surface water	Aquatic systems & sediments	Not Available
52	Seawater	Aquatic systems & sediments	Not Available
53	Freshwater	Aquatic systems & sediments	Not Available
70	Stormwater runoff	Automotive & urban infrastructure	Not Available
88	Waterproofing sprays	Building & Construction	Not Available
115	Drinking water	Drinking water & water supply	Not Available
116	Tap water	Drinking water & water supply	Not Available
117	Bottled water	Drinking water & water supply	Not Available
118	Desalinated water	Drinking water & water supply	Not Available
181	Ballast water	Marine, shipping & aquaculture	Not Available
182	Bilge water	Marine, shipping & aquaculture	Not Available
233	Brushes	Personal care & cosmetics	Not Available
468	Industrial wastewater	Wastewater, sanitation & biosolids	Not Available
470	Wastewater treatment effluent	Wastewater, sanitation & biosolids	Not Available
475	Mine wastewater	Wastewater, sanitation & biosolids	Not Available
477	Wastewater, unspecified	Wastewater, sanitation & biosolids	Not Available
491		Industrial manufacturing & chemical processing	Not Available
494	Food contact materials	Food, food processing & cookware	Not Available
495	Ceilings	Building & Construction	Not Available
496	Fencing	Building & Construction	Not Available
497	Floors	Building & Construction	Not Available
500	Stairs And Ramps	Building & Construction	Not Available
503	Tents Or Canopies	Building & Construction	Not Available
504	Adjustable Resistors	Electrical & Electronic Equipment	Not Available
505	Amplifiers	Electrical & Electronic Equipment	Not Available
506	Antennas	Electrical & Electronic Equipment	Not Available
507	Auxiliary Devices	Electrical & Electronic Equipment	Not Available
508	Coils	Electrical & Electronic Equipment	Not Available
510	Communication Cables Or Conductors	Electrical & Electronic Equipment	Not Available
511	Conductors Or Conductive Bodies Characterised By The Conductive Materials	Electrical & Electronic Equipment	Not Available
513	Cores Yokes Or Armatures	Electrical & Electronic Equipment	Not Available
514	Discharge Lamps	Electrical & Electronic Equipment	Not Available
516	Electric Hearing Aids	Electrical & Electronic Equipment	Not Available
517	Electric Switches	Electrical & Electronic Equipment	Not Available
518	Electrically Stimulated Smoking Devices	Electrical & Electronic Equipment	Not Available
519	Electrodes	Electrical & Electronic Equipment	Not Available
520	Emergency Protective Devices	Electrical & Electronic Equipment	Not Available
521	Fixed Capacitors And Their Manufacture	Electrical & Electronic Equipment	Not Available
523	Gas Filled Discharge Tubes With Solid Cathode	Electrical & Electronic Equipment	Not Available
524	Hybrid Capacitors	Electrical & Electronic Equipment	Not Available
525	Line Transmission Systems	Electrical & Electronic Equipment	Not Available
527	Magnets	Electrical & Electronic Equipment	Not Available
528	Microphones	Electrical & Electronic Equipment	Not Available
529	Power Cables	Electrical & Electronic Equipment	Not Available
530	Radio Transmission Systems	Electrical & Electronic Equipment	Not Available
531	Relays	Electrical & Electronic Equipment	Not Available
535	Superconducting Magnets And Superconducting Coils	Electrical & Electronic Equipment	Not Available
536	Superconductive Or Hyperconductive Conductors Cables Or Transmission Lines	Electrical & Electronic Equipment	Not Available
537	Television Systems	Electrical & Electronic Equipment	Not Available
538	Thin Magnetic Films	Electrical & Electronic Equipment	Not Available
539	Video Games	Electrical & Electronic Equipment	Not Available
544	Fermentation Processes For Beer	Food, food processing & cookware	Not Available
545	Food Preservation	Food, food processing & cookware	Not Available
547	Preparation Of Malt	Food, food processing & cookware	Not Available
552	Processing Meats	Food, food processing & cookware	Not Available
555	Bleaching Agents	Household cleaning & consumer products	Not Available
556	Cigar Cigarettes	Household cleaning & consumer products	Not Available
559	Non Electric Simulated Smoking Devices	Household cleaning & consumer products	Not Available
560	Other Smoking Requisites	Household cleaning & consumer products	Not Available
561	Perfumes Within Detergents And Soaps	Household cleaning & consumer products	Not Available
562	Pipe Accessories	Household cleaning & consumer products	Not Available
563	Soap Detergents	Household cleaning & consumer products	Not Available
564	Soap Dispensers	Household cleaning & consumer products	Not Available
566	Tobacco Pipes	Household cleaning & consumer products	Not Available
569	Tobacco Smoke Filters	Household cleaning & consumer products	Not Available
578	Making Cigars	Industrial manufacturing & chemical processing	Not Available
579	Manufacture Of Iron Or Steel	Industrial manufacturing & chemical processing	Not Available
580	Manufacture Preparation Of Tobacco Products	Industrial manufacturing & chemical processing	Not Available
581	Paper Making Machines	Industrial manufacturing & chemical processing	Not Available
583	Anchoring Equipment	Marine, shipping & aquaculture	Not Available
584	Buoys	Marine, shipping & aquaculture	Not Available
585	Canoes And Kayaks	Marine, shipping & aquaculture	Not Available
592	Marine Propulsion Or Steering	Marine, shipping & aquaculture	Not Available
598	Fertiliser Distributors	Agriculture & land management	Not Available
600	Herbicides And Algicides	Agriculture & land management	Not Available
605	Pest Repellants	Agriculture & land management	Not Available
606	Plant Growth Regulators	Agriculture & land management	Not Available
609	Aftershave	Personal care & cosmetics	Not Available
610	Aftersun Products	Personal care & cosmetics	Not Available
611	Anti Perspirants Or Body Deoderants	Personal care & cosmetics	Not Available
612	Body Washing Or Cleaning Implements	Personal care & cosmetics	Not Available
613	Depilatories	Personal care & cosmetics	Not Available
614	Essential Oils Or Perfumes	Personal care & cosmetics	Not Available
615	Eye Makeup Products	Personal care & cosmetics	Not Available
618	Lip Makeup Products	Personal care & cosmetics	Not Available
619	Manicure Pedicure	Personal care & cosmetics	Not Available
620	Card Games	Recreation & sports surfaces	Not Available
622	Game Accessories	Recreation & sports surfaces	Not Available
625	Racing Sports	Recreation & sports surfaces	Not Available
630	Toys	Recreation & sports surfaces	Not Available
631	Anthraquinone Dyes	Textiles, leather & furnishings	Not Available
632	Apparel	Textiles, leather & furnishings	Not Available
633	Azo Dyes	Textiles, leather & furnishings	Not Available
634	Buckles	Textiles, leather & furnishings	Not Available
635	Buttons	Textiles, leather & furnishings	Not Available
638	Decorating Textiles	Textiles, leather & furnishings	Not Available
642	Footwear	Textiles, leather & furnishings	Not Available
643	Headwear	Textiles, leather & furnishings	Not Available
645	Inorganic Fibres	Textiles, leather & furnishings	Not Available
650	Purses Luggage Hand Bags	Textiles, leather & furnishings	Not Available
652	Ropes	Textiles, leather & furnishings	Not Available
653	Sewing	Textiles, leather & furnishings	Not Available
655	Slide Fasteners	Textiles, leather & furnishings	Not Available
657	Surface Finishing Of Leather	Textiles, leather & furnishings	Not Available
658	Touch Fasteners	Textiles, leather & furnishings	Not Available
659	Transfer Printing	Textiles, leather & furnishings	Not Available
661	Umbrellas	Textiles, leather & furnishings	Not Available
662	Yarns Or Threads	Textiles, leather & furnishings	Not Available

Pathways

0 pathways

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2	P11507	Rattus norvegicus	Predicted (SEA)	0.0778492
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Predicted (SEA)	1.40129
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	4.28171
Click to view 3D structure	Nuclear receptor ROR-gamma	P51449	Humans	Predicted (SEA)	15.8812
Click to view 3D structure	Estrogen-related receptor gamma	P62508	Humans	Predicted (SEA)	1.86838
Click to view 3D structure	Polyunsaturated fatty acid lipoxygenase ALOX15	P12530	Oryctolagus cuniculus	Predicted (SEA)	0.544945
Click to view 3D structure	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	Oryctolagus cuniculus	Predicted (SEA)	0.0778492
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	72.789
Click to view 3D structure	Glycogen synthase kinase-3 beta	P49841	Humans	Predicted (SEA)	218.834
Click to view 3D structure	Carbonic anhydrase 3	P07451	Humans	Predicted (SEA)	4.12601
Click to view 3D structure	Androgen receptor	P10275	Humans	Predicted (SEA)	25.7681
Click to view 3D structure	Carbonic anhydrase 2	P00918	Humans	Predicted (SEA)	93.7305
Click to view 3D structure	Carbonic anhydrase 12	O43570	Humans	Predicted (SEA)	69.1301
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Q9Y463	Humans	Predicted (SEA)	89.7602
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Q13627	Humans	Predicted (SEA)	225.841
Click to view 3D structure	Dual specificity protein kinase CLK2	P49760	Humans	Predicted (SEA)	223.349
Click to view 3D structure	Dual specificity protein kinase CLK4	Q9HAZ1	Humans	Predicted (SEA)	224.361
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 3	O43781	Humans	Predicted (SEA)	115.217
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 4	Q9NR20	Humans	Predicted (SEA)	110.624
Click to view 3D structure	Dual specificity tyrosine-phosphorylation-regulated kinase 2	Q92630	Humans	Predicted (SEA)	56.7521
Click to view 3D structure	Dual specificity protein kinase CLK1	P49759	Humans	Predicted (SEA)	123.469
Click to view 3D structure	Dual specificity protein kinase CLK3	P49761	Humans	Predicted (SEA)	80.9632
Click to view 3D structure	Casein kinase I isoform epsilon	P49674	Humans	Predicted (SEA)	98.0122
Click to view 3D structure	Carbonic anhydrase 9	Q16790	Humans	Predicted (SEA)	187.383
Click to view 3D structure	Prostaglandin G/H synthase 2	P35354	Humans	Predicted (SEA)	89.6045
Click to view 3D structure	Nuclear receptor subfamily 1 group I member 3	Q14994	Humans	Known	Not Available
Click to view 3D structure	Estrogen receptor	P03372	Humans	Known	Bisphenol-A (BPA) has been reported to bind to the estrogen receptor (ER) and also to act as a xenoestrogen on the reproductive system of many species. (A281)
Click to view 3D structure	Nuclear receptor subfamily 1 group I member 2	O75469	Humans	Known	Not Available
Click to view 3D structure	Estrogen receptor beta	Q92731	Humans	Known	Bisphenol-A (BPA) has been reported to bind to the estrogen receptor (ER) and also to act as a xenoestrogen on the reproductive system of many species. (A281)
Click to view 3D structure	Progesterone receptor	P06401	Humans	Known	Not Available
Click to view 3D structure	Androgen receptor	P10275	Humans	Known	Tumor-derived mutants of the androgen receptor are receptive to activation by bisphenol A (BPA). (A282)
Click to view 3D structure	Estrogen-related receptor gamma	P62508	Humans	Known	Bisphenol A (BPA) functions at very low doses as an endocrine disruptor. The human estrogen-related receptor gamma (ERR gamma) behaves as a constitutive activator of transcription, although the endogenous ligand is unknown. (A283)
Click to view 3D structure	Aryl hydrocarbon receptor	P35869	Humans	Known	Not Available
Click to view 3D structure	G-protein coupled estrogen receptor 1	Q99527	Humans	Known	Not Available
Click to view 3D structure	Peroxisome proliferator-activated receptor alpha	Q07869	Humans	Known	Not Available
Click to view 3D structure	Peroxisome proliferator-activated receptor delta	Q03181	Humans	Known	Not Available
Click to view 3D structure	Peroxisome proliferator-activated receptor gamma	P37231	Humans	Known	Not Available
Click to view 3D structure	Prostaglandin G/H synthase 1	P23219	Humans	Known	Not Available
Click to view 3D structure	Protein disulfide-isomerase	P07237	Humans	Known	The binding activity of L-T3 and 17beta-estradiol hormones to PDI was competitively inhibited by BPA. This in turn abolishes PDIs isomerase activities. (A280)
Click to view 3D structure	Retinoic acid receptor RXR-alpha	P19793	Humans	Known	Not Available
Click to view 3D structure	Retinoic acid receptor RXR-beta	P28702	Humans	Known	Not Available
Click to view 3D structure	Retinoic acid receptor RXR-gamma	P48443	Humans	Known	Not Available
Click to view 3D structure	Sodium channel protein type 5 subunit alpha	Q14524	Humans	Known	Not Available
Click to view 3D structure	Tubulin alpha-1C chain	Q9BQE3	Humans	Known	Not Available
Click to view 3D structure	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2B6	P20813	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 3A5	P20815	Humans	Known	Not Available
Click to view 3D structure	C-C motif chemokine 2	P13500	Humans	Known	Not Available
Click to view 3D structure	C-X-C motif chemokine 10	P02778	Humans	Known	Not Available
Click to view 3D structure	Transforming growth factor beta-1 proprotein	P01137	Humans	Known	Not Available
Click to view 3D structure	Tumor necrosis factor receptor superfamily member 5	P25942	Humans	Known	Not Available
Click to view 3D structure	Vascular cell adhesion protein 1	P19320	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2C19	P33261	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2J2	P51589	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 1A1	P04798	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2C18	P33260	Humans	Known	Not Available
Click to view 3D structure	Adenosine receptor A1	P30542	Humans	Known	Not Available
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Known	Not Available
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Known	Not Available
Click to view 3D structure	Delta-type opioid receptor	P41143	Humans	Known	Not Available
Click to view 3D structure	Mu-type opioid receptor	P35372	Humans	Known	Not Available