Zinc chlorate (CED0007108)

Record Information
Version1.0
Creation Date2009-03-27 00:35:27 UTC
Update Date2026-04-05 21:34:01 UTC
SynCED IDCED0007108
Secondary Accession Numbers
  • CHEM000651
  • T3D0724
Identification
Common NameZinc chlorate
ClassSmall Molecule
Description
Zinc chlorate (Cl2O6Zn) is an exogenous inorganic compound with an average molecular weight of 232.31 g/mol. It exists as a solid at room temperature. Zinc chlorate belongs to the transition metal chlorates, a subclass of transition metal oxoanionic compounds within the inorganic compounds. The compound is recorded as being found in or released from two sources: bleaching agents used in household cleaning and consumer products, and radio transmission systems within electrical and electronic equipment. Regarding its biological activity, one protein target is recorded as superoxide dismutase [Cu-Zn] (SOD1). Unbalanced levels of copper and zinc binding to this specific enzyme have been linked to amyotrophic lateral sclerosis (ALS).
Contaminant Type
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Synthetic Compound
  • Zinc Compound
Chemical Structure
Synonyms
ValueSource
Zinc CHLoric acidGenerator
Chemical FormulaCl2O6Zn
Average Molecular Mass232.311 g/mol
Monoisotopic Mass229.836 g/mol
CAS Registry Number10361-95-2
IUPAC Name(chloryloxy)zincio chlorate
Traditional Name(chloryloxy)zincio chlorate
SMILESO=[Cl](=O)O[Zn]O[Cl](=O)=O
InChI IdentifierInChI=1S/2ClHO3.Zn/c2*2-1(3)4;/h2*(H,2,3,4);/q;;+2/p-2
InChI KeyGTQFPPIXGLYKCZ-UHFFFAOYSA-L
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as transition metal chlorates. These are inorganic compounds in which the largest oxoanion is chlorate, and in which the heaviest atom not in an oxoanion is a transition metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassTransition metal oxoanionic compounds
Sub ClassTransition metal chlorates
Direct ParentTransition metal chlorates
Alternative Parents
Substituents
  • Transition metal chlorate
  • Inorganic oxide
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Organoleptic EffectsNot Available
Physical Properties
StateSolid
AppearanceYellow crystals.
Experimental Properties
PropertyValue
Melting Point60°C (decomposes)
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
logP-0.34ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area86.74 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity20.74 m³·mol⁻¹ChemAxon
Polarizability11.24 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
SpectraNot Available
Toxicity Profile
Toxicity ValuesNot Available
Toxicity / Toxin ClassNot Available
Mechanism of ToxicityAnaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (2, 3, 1)
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Minimum Risk LevelIntermediate Oral: 0.3 mg/kg/day (6) Chronic Oral: 0.3 mg/kg/day (6)
SymptomsIngestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (3)
TreatmentZinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (3)
Health Effects
Health EffectRelationshipDirectionDescriptionReference
Exposure Sources
Source IDSourceSectorReference
CEDs000511Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.Electrical & Electronic EquipmentPubChem
CEDs000519Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.Electrical & Electronic EquipmentPubChem
CEDs000524Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.Electrical & Electronic EquipmentPubChem
CEDs000530Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.Electrical & Electronic EquipmentPubChem
CEDs000545Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.Food, food processing & cookwarePubChem
CEDs000555Bleaching Agents?Bleaching agents are chemical substances used to whiten or lighten materials, often employed in various cleaning products for their stain removal and disinfecting properties.Household cleaning & consumer productsPubChem
CEDs000561Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.Household cleaning & consumer productsPubChem
CEDs000563Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.Household cleaning & consumer productsPubChem
CEDs000606Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.Agriculture & land managementPubChem
CEDs000611Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000612Body Washing Or Cleaning Implements?Body washing or cleaning implements, such as synthetic sponges, loofahs, and washcloths, can be sources of synthetic chemical contamination due to the materials used in their production.Personal care & cosmeticsPubChem
CEDs000613Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.Personal care & cosmeticsPubChem
CEDs000614Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.Personal care & cosmeticsPubChem
CEDs000617Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.Personal care & cosmeticsPubChem
CEDs000618Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.Personal care & cosmeticsPubChem
CEDs000678Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.Agriculture & land managementPubChem
CEDs000685Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.Building & ConstructionPubChem
CEDs000693Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.Building & ConstructionPubChem
CEDs000696Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.Industrial manufacturing & chemical processingPubChem
CEDs000734Coating Compositions?Coating compositions, which include paints, sealants, and varnishes, are formulated with a variety of synthetic chemicals such as solvents, resins, pigments, and additives.Building & ConstructionPubChem
CEDs000735Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.Defense & military infrastructurePubChem
CEDs000739Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.Paper, pulp & fiber productsPubChem
CEDs000740Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.Paper, pulp & fiber productsPubChem
CEDs000743Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.Wastewater, sanitation & biosolidsPubChem
CEDs000744Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.Wastewater, sanitation & biosolidsPubChem
Pathways
0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets
StructureProteinUniProt IDOrganismRelationshipDetails
Carbonic anhydrase 12 structureClick to view 3D structureCarbonic anhydrase 12O43570HumansPredicted (SEA)
Prediction Confidence Score
0.071
Applicability Domain
0.111 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
332
E-value
7784.69
Carbonic anhydrase 9 structureClick to view 3D structureCarbonic anhydrase 9Q16790HumansPredicted (SEA)
Prediction Confidence Score
0.069
Applicability Domain
0.111 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
372
E-value
7784.84
Carbonic anhydrase 4 structureClick to view 3D structureCarbonic anhydrase 4P22748HumansPredicted (SEA)
Prediction Confidence Score
0.067
Applicability Domain
0.111 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
193
E-value
7784.61
Thiamine transporter ThiT structureClick to view 3D structureThiamine transporter ThiTA2RI47Lactococcus lactis subsp. cremoris (strain MG1363)Predicted (SEA)
Prediction Confidence Score
0.067
Applicability Domain
0.068 Low confidence
Statistical Significance
0.8183
Supporting Reference Compounds
2
E-value
6370.56
Carbonic anhydrase 2 structureClick to view 3D structureCarbonic anhydrase 2P00918HumansPredicted (SEA)
Prediction Confidence Score
0.067
Applicability Domain
0.083 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
472
E-value
7784.77
Carbonic anhydrase 7 structureClick to view 3D structureCarbonic anhydrase 7P43166HumansPredicted (SEA)
Prediction Confidence Score
0.065
Applicability Domain
0.111 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
242
E-value
7784.53
Carbonic anhydrase 13 structureClick to view 3D structureCarbonic anhydrase 13Q8N1Q1HumansPredicted (SEA)
Prediction Confidence Score
0.065
Applicability Domain
0.111 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
92
E-value
7784.22
Replicase polyprotein 1ab structureClick to view 3D structureReplicase polyprotein 1abP0DTD1SARS-CoV-2Predicted (SEA)
Prediction Confidence Score
0.064
Applicability Domain
0.111 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
215
E-value
7784.69
Carbonic anhydrase 1 structureClick to view 3D structureCarbonic anhydrase 1P00915HumansPredicted (SEA)
Prediction Confidence Score
0.061
Applicability Domain
0.08 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
407
E-value
7784.92
Click to view 3D structureCarbonic anhydrase 5B, mitochondrialQ9Y2D0HumansPredicted (SEA)
Prediction Confidence Score
0.061
Applicability Domain
0.111 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
157
E-value
7784.53
Sodium-dependent noradrenaline transporter structureClick to view 3D structureSodium-dependent noradrenaline transporterP23975HumansPredicted (SEA)
Prediction Confidence Score
0.061
Applicability Domain
0.083 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
451
E-value
7784.61
Prothrombin structureClick to view 3D structureProthrombinP00734HumansPredicted (SEA)
Prediction Confidence Score
0.06
Applicability Domain
0.065 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
331
E-value
7784.61
72 kDa type IV collagenase structureClick to view 3D structure72 kDa type IV collagenaseP08253HumansPredicted (SEA)
Prediction Confidence Score
0.059
Applicability Domain
0.066 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
400
E-value
7784.69
Click to view 3D structureCarbonic anhydrase 5A, mitochondrialP35218HumansPredicted (SEA)
Prediction Confidence Score
0.059
Applicability Domain
0.111 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
165
E-value
7784.61
Suppressor of tumorigenicity 14 protein structureClick to view 3D structureSuppressor of tumorigenicity 14 proteinQ9Y5Y6HumansPredicted (SEA)
Prediction Confidence Score
0.059
Applicability Domain
0.061 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
74
E-value
7783.83
Stromelysin-1 structureClick to view 3D structureStromelysin-1P08254HumansPredicted (SEA)
Prediction Confidence Score
0.059
Applicability Domain
0.066 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
200
E-value
7784.53
Matrix metalloproteinase-9 structureClick to view 3D structureMatrix metalloproteinase-9P14780HumansPredicted (SEA)
Prediction Confidence Score
0.058
Applicability Domain
0.066 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
292
E-value
7784.61
Acrosin structureClick to view 3D structureAcrosinP08001Sus scrofaPredicted (SEA)
Prediction Confidence Score
0.057
Applicability Domain
0.063 Low confidence
Statistical Significance
0.9627
Supporting Reference Compounds
8
E-value
7494.31
Interstitial collagenase structureClick to view 3D structureInterstitial collagenaseP03956HumansPredicted (SEA)
Prediction Confidence Score
0.057
Applicability Domain
0.066 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
258
E-value
7784.53
Collagenase 3 structureClick to view 3D structureCollagenase 3P45452HumansPredicted (SEA)
Prediction Confidence Score
0.057
Applicability Domain
0.066 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
269
E-value
7784.53
Prostaglandin G/H synthase 2 structureClick to view 3D structureProstaglandin G/H synthase 2P35354HumansPredicted (SEA)
Prediction Confidence Score
0.056
Applicability Domain
0.073 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
201
E-value
7784.61
Coagulation factor X structureClick to view 3D structureCoagulation factor XP00742HumansPredicted (SEA)
Prediction Confidence Score
0.056
Applicability Domain
0.065 Low confidence
Statistical Significance
0.9999
Supporting Reference Compounds
284
E-value
7784.53
Click to view 3D structureDeoxycytidine kinaseP43346Mus musculusPredicted (SEA)
Prediction Confidence Score
0.056
Applicability Domain
0.061 Low confidence
Statistical Significance
0.9734
Supporting Reference Compounds
2
E-value
7578.23
Voltage-gated inwardly rectifying potassium channel KCNH2 structureClick to view 3D structureVoltage-gated inwardly rectifying potassium channel KCNH2Q12809HumansPredicted (SEA)
Prediction Confidence Score
0.055
Applicability Domain
0.061 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
1498
E-value
7784.69
5-hydroxytryptamine receptor 2C structureClick to view 3D structure5-hydroxytryptamine receptor 2CP28335HumansPredicted (SEA)
Prediction Confidence Score
0.055
Applicability Domain
0.061 Low confidence
Statistical Significance
1.0
Supporting Reference Compounds
823
E-value
7784.69
Superoxide dismutase [Cu-Zn] structureClick to view 3D structureSuperoxide dismutase [Cu-Zn]P00441HumansKnownUnbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). (A49)
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkZinc chlorate
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound ID25206
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References
  1. Vonk WI, Klomp LW: Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis. Biochem Soc Trans. 2008 Dec;36(Pt 6):1322-8. doi: 10.1042/BST0361322. [PubMed: 19021549]
  2. Wikipedia. Zinc. Last Updated 24 March 2009. - http://en.wikipedia.org/wiki/Zinc
  3. ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for zinc. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). - http://www.atsdr.cdc.gov/toxprofiles/tp60.html
  4. Wikipedia. Zinc chlorate. Last Updated 16 March 2009. - http://en.wikipedia.org/wiki/Zinc_chlorate
  5. Wikipedia. Metallothionein. Last Updated 20 December 2008. - http://en.wikipedia.org/wiki/Metallothionein
  6. ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). - http://www.atsdr.cdc.gov/mrls/