Antimony pentoxide (CED0027130)

Record Information

Version

1.0

Creation Date

2009-06-16 18:46:48 UTC

Update Date

2026-08-17 20:51:43 UTC

SynCED ID

CED0027130

Secondary Accession Numbers

CHEM000749
T3D0872

Identification

Common Name

Antimony pentoxide

Class

Small Molecule

Description

Antimony pentoxide is an exogenous inorganic compound with the formula H16O5Sb2 and an average molecular weight of 339.64 g/mol. It exists as a solid at room temperature. Antimony pentoxide belongs to the metalloid oxides, a subclass of metalloid organides within the inorganic compounds. The compound is used in plastics such as Polyethylene Terephthalate, Polyvinyl Chloride, Polystyrene, Polypropylene, Low-Density Polyethylene, High-Density Polyethylene, and Acrylonitrile butadiene styrene, and it is present in High impact polystyrene. It is found in or released from 23 recorded sources, including building and construction materials like roofs, fencing, and ceilings; household cleaning and consumer products such as soap dispensers, soap detergents, cigar cigarettes, and other smoking requisites; and electrical and electronic equipment, including antennas, communication cables or conductors, auxiliary devices, coils, and cores yokes or armatures. Antimony pentoxide has 19 recorded protein targets, including Glutathione S-transferase A1 (GSTA1), Glutathione S-transferase A2 (GSTA2), Glutathione S-transferase A3 (GSTA3), and Glutathione S-transferase Mu 4 (GSTM4). Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, which reduces their detoxification ability.

Contaminant Type

Antimony Compound
Food Toxin
Inorganic Compound
Metalloid
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Pentahydric acid distibane	Generator

Chemical Formula

H₁₆O₅Sb₂

Average Molecular Mass

339.643 g/mol

Monoisotopic Mass

337.907 g/mol

CAS Registry Number

1314-60-9

IUPAC Name

pentahydrate distibane

Traditional Name

pentahydrate distibane

SMILES

O.O.O.O.O.[SbH3].[SbH3]

InChI Identifier

InChI=1S/5H2O.2Sb.6H/h5*1H2;;;;;;;;

InChI Key

BCWKNNQEGZCUNI-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as metalloid oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a metalloid.

Kingdom

Inorganic compounds

Super Class

Mixed metal/non-metal compounds

Class

Metalloid organides

Sub Class

Metalloid oxides

Direct Parent

Metalloid oxides

Alternative Parents

Substituents

Metalloid oxide
Inorganic antimony salt
Inorganic oxide
Inorganic salt
Inorganic metalloid salt

Molecular Framework

Not Available

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	380°C
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
logP	-0.65	ChemAxon
pKa (Strongest Acidic)	15.7	ChemAxon
pKa (Strongest Basic)	-1.8	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	1	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	25.3 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	3.7 m³·mol⁻¹	ChemAxon
Polarizability	1.51 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-fbfa9e1097750a83bcfb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-fbfa9e1097750a83bcfb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0009000000-fbfa9e1097750a83bcfb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-0009000000-cdc134b2633e7a58465c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-0009000000-cdc134b2633e7a58465c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0002-0009000000-cdc134b2633e7a58465c	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
4000.0 mg/kg	Rat	LD50	Oral	experimental	Not Available	5
978.0 mg/kg	Mice	LD50	Oral	experimental	Not Available	5

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. Antimony pentoxide might enhance the rate of heme degradation in liver and kidney. (2, 6, 4, 1)

Carcinogenicity (IARC Classification)

No indication of carcinogenicity (not listed by IARC). (3)

Minimum Risk Level

Not Available

Symptoms

Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (8, 4)

Treatment

Following oral exposure to antimony, administer charcoal as a slurry (240 mL water/30 g charcoal). Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (7)

Health Effects

Health Effect	Relationship	Direction	Description	Reference
pneumoconiosis	Associated With?	Not Available	An interstitial lung disease that is caused by the inhalation of dust. (DO)	PMC8047740

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000495	Ceilings?Ceilings in built environments can be a source of synthetic chemical contamination due to the materials used in their construction and finishes.	Building & Construction	PubChem
CEDs000496	Fencing?Fencing materials, particularly those used in construction and landscaping, can be a source of synthetic chemical contamination due to the treatments and coatings applied for durability and weather resistance.	Building & Construction	PubChem
CEDs000499	Roofs?Roofs can be a significant source of synthetic chemical contamination due to the materials used in their construction and maintenance.	Building & Construction	PubChem
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000507	Auxiliary Devices?Auxiliary devices, such as capacitors, transformers, and circuit breakers, are integral components in various electronic systems.	Electrical & Electronic Equipment	PubChem
CEDs000508	Coils?Coils are components used in various electrical and electronic applications, such as transformers, inductors, and motors.	Electrical & Electronic Equipment	PubChem
CEDs000510	Communication Cables Or Conductors?Communication cables or conductors are essential components in the transmission of data and signals in various applications, including telecommunications and networking.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000513	Cores Yokes Or Armatures?Cores, yokes, or armatures are components commonly found in electrical devices, used to facilitate the magnetic and electrical functions within motors, transformers, and generators.	Electrical & Electronic Equipment	PubChem
CEDs000514	Discharge Lamps?Discharge lamps, including fluorescent and high-intensity discharge (HID) lamps, are commonly used for lighting applications due to their energy efficiency and brightness.	Electrical & Electronic Equipment	PubChem
CEDs000517	Electric Switches?Electric switches, integral components in numerous devices, can be a source of synthetic chemical contamination due to the materials and manufacturing processes involved in their production.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000520	Emergency Protective Devices?Emergency protective devices, such as circuit breakers and surge protectors, are essential components in electrical systems designed to prevent damage from overcurrent and surges.	Electrical & Electronic Equipment	PubChem
CEDs000521	Fixed Capacitors And Their Manufacture?Fixed capacitors are passive electronic components used to store and release electrical energy, playing a critical role in various circuits.	Electrical & Electronic Equipment	PubChem
CEDs000524	Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.	Electrical & Electronic Equipment	PubChem
CEDs000527	Magnets?Magnets, commonly used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials used in their production.	Electrical & Electronic Equipment	PubChem
CEDs000531	Relays?Relays are electromechanical switches used to control circuits and manage electrical loads.	Electrical & Electronic Equipment	PubChem
CEDs000533	Sparking Plugs?Spark plugs are critical components in internal combustion engines, facilitating the ignition of fuel-air mixtures by generating a spark.	Electrical & Electronic Equipment	PubChem
CEDs000537	Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.	Electrical & Electronic Equipment	PubChem
CEDs000538	Thin Magnetic Films?Thin magnetic films are layers of magnetic material ranging from a few nanometers to several micrometers in thickness, commonly used in applications such as magnetic sensors, data storage devices, and electronic components.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000560	Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.	Household cleaning & consumer products	PubChem
CEDs000563	Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.	Household cleaning & consumer products	PubChem
CEDs000564	Soap Dispensers?Soap dispensers, commonly used for dispensing liquid soaps and sanitizers, can become a source of synthetic chemical contamination due to the materials used in their construction and the products they dispense.	Household cleaning & consumer products	PubChem
CEDs000581	Paper Making Machines?Paper making machines utilize various synthetic chemicals throughout the production process, including additives, coatings, and bleaching agents.	Industrial manufacturing & chemical processing	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000630	Toys?Toys, particularly those made from synthetic materials such as plastics, can be a source of chemical contamination due to the presence of various additives and compounds used in their production.	Recreation & sports surfaces	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000643	Headwear?Headwear made from synthetic materials often incorporates chemicals used in the manufacturing and finishing processes, such as dyes, flame retardants, and water repellents.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000652	Ropes?Ropes manufactured from synthetic fibers, such as polypropylene, nylon, and polyester, are widely used in various applications, including marine, construction, and outdoor activities.	Textiles, leather & furnishings	PubChem
CEDs000653	Sewing?Sewing processes often involve the use of various synthetic chemicals, which can become sources of contamination in the environment.	Textiles, leather & furnishings	PubChem
CEDs000654	Sleeve Links?Sleeve links are components typically used in the manufacturing of garments and accessories, particularly in the production of high-quality clothing items.	Textiles, leather & furnishings	PubChem
CEDs000655	Slide Fasteners?Slide fasteners, commonly known as zippers, are mechanical devices used to join two edges of fabric or other materials.	Textiles, leather & furnishings	PubChem
CEDs000657	Surface Finishing Of Leather?Surface finishing of leather often involves the use of various synthetic chemicals, including dyes, resins, and finishing agents.	Textiles, leather & furnishings	PubChem
CEDs000658	Touch Fasteners?Touch fasteners, commonly known as hook-and-loop fasteners, are composed of synthetic materials such as nylon or polyester.	Textiles, leather & furnishings	PubChem
CEDs000659	Transfer Printing?Transfer printing is a process used to apply designs and patterns onto various substrates, commonly utilizing synthetic dyes and inks that can contain hazardous chemicals.	Textiles, leather & furnishings	PubChem
CEDs000662	Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.	Textiles, leather & furnishings	PubChem
CEDs000664	Fire Fighting Gels?Fire fighting gels are synthetic chemical formulations designed to enhance fire suppression effectiveness by creating a protective barrier against heat and flames.	Fire suppression systems & agents	PubChem
CEDs000665	Fire Extinguishers?Fire extinguishers contain various synthetic chemicals designed to suppress flames and prevent the spread of fire.	Fire suppression systems & agents	PubChem
CEDs000670	Solid Fire Fighting Substances?Solid fire fighting substances, such as certain types of dry chemical powders, are used in fire suppression applications to extinguish flames and prevent fire spread.	Fire suppression systems & agents	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000678	Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.	Agriculture & land management	PubChem
CEDs000679	Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.	Agriculture & land management	PubChem
CEDs000684	Cements?Cements are a composite material primarily used as a binding agent in construction applications, formed by the calcination of limestone and clay minerals at high temperatures.	Building & Construction	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000686	Clay Wares?Clay wares are ceramic products made from natural clay, often utilized in various construction applications such as tiles, bricks, and sanitary ware.	Building & Construction	PubChem
CEDs000687	Crystal Glass?Crystal glass, known for its clarity and brilliance, is often produced using lead oxide, which enhances its refractive quality.	Building & Construction	PubChem
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	PubChem
CEDs000692	Silica Free Oxide Glass?Silica Free Oxide Glass is a type of glass that is produced using alternative materials to traditional silica-based formulations.	Building & Construction	PubChem
CEDs000693	Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	PubChem
CEDs000703	Blackboards?Blackboards, traditionally made from slate or coated wood, can also be produced using synthetic materials that may contain various chemicals.	Paper, pulp & fiber products	PubChem
CEDs000734	Coating Compositions?Coating compositions, which include paints, sealants, and varnishes, are formulated with a variety of synthetic chemicals such as solvents, resins, pigments, and additives.	Building & Construction	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000736	Fuses?Fuses are safety devices designed to protect electrical circuits by breaking the circuit when excessive current flows through.	Electrical & Electronic Equipment	PubChem
CEDs000737	Chemical Igniters?Chemical igniters are substances or devices designed to initiate combustion in various applications, often found in products like lighters, candles, and certain household cleaning agents.	Household items	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000741	Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.	Paper, pulp & fiber products	PubChem
CEDs000742	Leather Tanning?Leather tanning is a process that transforms raw animal hides into durable leather through the application of various chemicals, including chromium salts, aldehydes, and vegetable tannins.	Textiles, leather & furnishings	PubChem
CEDs000743	Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.	Wastewater, sanitation & biosolids	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs02590	Dust	Air, dust & atmospheric transport	PMC8047740

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Carbonic anhydrase 1	P00915	Humans	Predicted (SEA)	Prediction Confidence Score 0.061 Applicability Domain 0.143 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 407 E-value 7784.92
Click to view 3D structure	Carbonic anhydrase 2	P00918	Humans	Predicted (SEA)	Prediction Confidence Score 0.044 Applicability Domain 0.059 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 472 E-value 7784.92
Click to view 3D structure	Carbonic anhydrase 9	Q16790	Humans	Predicted (SEA)	Prediction Confidence Score 0.039 Applicability Domain 0.045 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 372 E-value 7784.92
Click to view 3D structure	Glyceraldehyde-3-phosphate dehydrogenase	P46406	Oryctolagus cuniculus	Predicted (SEA)	Prediction Confidence Score 0.037 Applicability Domain 0.037 Low confidence Statistical Significance 0.8735 Supporting Reference Compounds 1 E-value 6800.44
Click to view 3D structure	Amine oxidase [flavin-containing] B	P27338	Humans	Predicted (SEA)	Prediction Confidence Score 0.036 Applicability Domain 0.077 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 315 E-value 7784.69
Click to view 3D structure	Interleukin-18	Q14116	Humans	Predicted (SEA)	Prediction Confidence Score 0.034 Applicability Domain 0.034 Low confidence Statistical Significance 0.9939 Supporting Reference Compounds 1 E-value 7737.59
Click to view 3D structure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	O00329	Humans	Predicted (SEA)	Prediction Confidence Score 0.034 Applicability Domain 0.038 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 459 E-value 7784.69
Click to view 3D structure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	P42338	Humans	Predicted (SEA)	Prediction Confidence Score 0.033 Applicability Domain 0.038 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 372 E-value 7784.69
Click to view 3D structure	Epidermal growth factor receptor	P00533	Humans	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.043 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 1301 E-value 7784.84
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.037 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 861 E-value 7784.92
Click to view 3D structure	Interferon alpha/beta receptor 1	P17181	Humans	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.032 Low confidence Statistical Significance 0.9956 Supporting Reference Compounds 1 E-value 7750.9
Click to view 3D structure	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	Humans	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.038 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 450 E-value 7784.69
Click to view 3D structure	Estrogen receptor	P03372	Humans	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.038 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 201 E-value 7784.69
Click to view 3D structure	Replicase polyprotein 1ab	K9N7C7	Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.045 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 48 E-value 7784.77
Click to view 3D structure	Adenosine receptor A2a	P29274	Humans	Predicted (SEA)	Prediction Confidence Score 0.032 Applicability Domain 0.036 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 303 E-value 7784.77
Click to view 3D structure	Dual specificity mitogen-activated protein kinase kinase 4	P45985	Humans	Predicted (SEA)	Prediction Confidence Score 0.031 Applicability Domain 0.071 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 113 E-value 7784.61
Click to view 3D structure	Replicase polyprotein 1ab	P0DTD1	SARS-CoV-2	Predicted (SEA)	Prediction Confidence Score 0.031 Applicability Domain 0.045 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 215 E-value 7784.77
Click to view 3D structure	Induced myeloid leukemia cell differentiation protein Mcl-1	Q07820	Humans	Predicted (SEA)	Prediction Confidence Score 0.03 Applicability Domain 0.037 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 343 E-value 7784.69
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Predicted (SEA)	Prediction Confidence Score 0.03 Applicability Domain 0.031 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 487 E-value 7784.92
Click to view 3D structure	Carbonic anhydrase 5A, mitochondrial	P35218	Humans	Predicted (SEA)	Prediction Confidence Score 0.03 Applicability Domain 0.045 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 165 E-value 7784.84
Click to view 3D structure	Tyrosine-protein kinase Lck	P06239	Humans	Predicted (SEA)	Prediction Confidence Score 0.03 Applicability Domain 0.043 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 1130 E-value 7784.84
Click to view 3D structure	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	Humans	Predicted (SEA)	Prediction Confidence Score 0.03 Applicability Domain 0.04 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 48 E-value 7784.69
Click to view 3D structure	Carbonic anhydrase 12	O43570	Humans	Predicted (SEA)	Prediction Confidence Score 0.03 Applicability Domain 0.059 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 332 E-value 7784.84
Click to view 3D structure	L-lactate dehydrogenase B chain	P16125	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.029 Applicability Domain 0.029 Low confidence Statistical Significance 0.9941 Supporting Reference Compounds 1 E-value 7739.15
Click to view 3D structure	3',5'-cyclic-AMP phosphodiesterase 4A	O89085	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.029 Applicability Domain 0.029 Low confidence Statistical Significance 0.9956 Supporting Reference Compounds 1 E-value 7751.06
Click to view 3D structure	Glutathione S-transferase A1	P08263	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase A2	P09210	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase A3	Q16772	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase A5	Q7RTV2	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase Mu 1	P09488	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase Mu 2	P28161	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase Mu 3	P21266	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase Mu 4	Q03013	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase Mu 5	P46439	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase P	P09211	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase kappa 1	Q9Y2Q3	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase omega-1	P78417	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase omega-2	Q9H4Y5	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase theta-1	P30711	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase theta-2	P0CG29	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Maleylacetoacetate isomerase	O43708	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Microsomal glutathione S-transferase 1	P10620	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Microsomal glutathione S-transferase 2	Q99735	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)
Click to view 3D structure	Glutathione S-transferase 3, mitochondrial	O14880	Humans	Known	Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (L137)

Concentrations

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External Links

DrugBank ID

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HMDB ID

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FooDB ID

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Phenol Explorer ID

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KNApSAcK ID

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BiGG ID

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BioCyc ID

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METLIN ID

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PDB ID

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Wikipedia Link

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Chemspider ID

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ChEBI ID

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PubChem Compound ID

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Kegg Compound ID

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YMDB ID

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ECMDB ID

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References

Synthesis Reference

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MSDS

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General References

Poon R, Chu I, Lecavalier P, Valli VE, Foster W, Gupta S, Thomas B: Effects of antimony on rats following 90-day exposure via drinking water. Food Chem Toxicol. 1998 Jan;36(1):21-35. [PubMed: 9487361]
Drummond GS, Kappas A: Potent heme-degrading action of antimony and antimony-containing parasiticidal agents. J Exp Med. 1981 Feb 1;153(2):245-56. [PubMed: 6894611]
International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. - http://monographs.iarc.fr/index.php
ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for antimony. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). - http://www.atsdr.cdc.gov/toxprofiles/tp23.html
Chem YQ (2009). Antimony pentoxide. - http://www.hellochem.com/En/xz/xz1/3079hlccv.htm
Hayes WJ Jr. and Laws ER Jr. (eds) (1991). Handbook of Pesticide Toxicology. Volume 3. Classes of Pesticides. New York, NY: Academic Press, Inc.
Rumack BH (2009). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 141, edition expires Aug, 2009.
Hamilton A and Hardy HL (1974). Industrial Toxicology. 3rd ed. Acton, MA: Publishing Sciences Group, Inc.

Antimony pentoxide (CED0027130)

Structure for CHEM000749: Antimony pentoxide

No pathways found

Structure