Propoxur (CED0007131)

Record Information

Version

1.0

Creation Date

2009-06-17 23:53:05 UTC

Update Date

2026-08-18 11:21:29 UTC

SynCED ID

CED0007131

Secondary Accession Numbers

CHEM000862
T3D1003

Identification

Common Name

Propoxur

Class

Small Molecule

Description

Propoxur belongs to the phenol ethers, a class of benzenoids within the organic compounds. It is an exogenous solid with the formula C11H15NO3 and an average molecular weight of 209.24 g/mol. This compound serves as an agrochemical, biocide, and carbamate insecticide (PMC7799788 ). Its biological and chemical roles include acting as an insecticide and an acaricide, as well as functioning as an EC 3.1.1.7 (acetylcholinesterase) inhibitor (PMC7799788 ). Industrially, it is also identified as a degradant or impurity (PMC7799788 ). Propoxur targets ten recorded proteins, including C-C motif chemokine 2 (CCL2), Cytochrome P450 2B6 (CYP2B6), Cytochrome P450 2C9 (CYP2C9), Cytochrome P450 3A4 (CYP3A4), and five others. It specifically targets cholinesterase (BCHE), where its mode of action is the inhibition of cholinesterase enzymes, which affects nerve impulse transmission. The compound is found in or released from 23 recorded sources. These include drinking water, indoor air, and building and construction materials such as tents or canopies. It is present in household cleaning and consumer products, including soap dispensers, soap detergents, perfumes within detergents and soaps, cigar cigarettes, and tobacco smoke filters. It is also associated with food preservation and the preparation of malt. Additionally, it is found in electrical and electronic equipment, such as electric switches, electric hearing aids, antennas, conductors or conductive bodies characterised by the conductive materials, and electrically stimulated smoking devices. Recorded exposure routes for propoxur include oral and inhalation.

Contaminant Type

Amine
Carbamate
Ester
Ether
Household Toxin
Human Neurotoxin
Organic Compound
Pesticide
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-(1-Methylethoxy)phenyl methylcarbamate	ChEBI
2-Isopropoxyphenyl methylcarbamate	ChEBI
2-Isopropoxyphenyl N-methylcarbamate	ChEBI
Aprocarb	ChEBI
Baygon	ChEBI
Bolfo	Kegg
2-(1-Methylethoxy)phenyl methylcarbamic acid	Generator
2-Isopropoxyphenyl methylcarbamic acid	Generator
2-Isopropoxyphenyl N-methylcarbamic acid	Generator
Unden	MeSH
O Isopropoxyphenylmethylcarbamate	MeSH
O-Isopropoxyphenylmethylcarbamate	MeSH
Sendran	MeSH

Chemical Formula

C₁₁H₁₅NO₃

Average Molecular Mass

209.242 g/mol

Monoisotopic Mass

209.105 g/mol

CAS Registry Number

114-26-1

IUPAC Name

2-(propan-2-yloxy)phenyl N-methylcarbamate

Traditional Name

rhoden

SMILES

CNC(=O)OC1=CC=CC=C1OC(C)C

InChI Identifier

InChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13)

InChI Key

ISRUGXGCCGIOQO-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Phenol ethers

Sub Class

Not Available

Direct Parent

Phenol ethers

Alternative Parents

Substituents

Phenoxy compound
Phenol ether
Alkyl aryl ether
Monocyclic benzene moiety
Carboximidic acid derivative
Ether
Propargyl-type 1,3-dipolar organic compound
Organic 1,3-dipolar compound
Organooxygen compound
Organonitrogen compound
Imine
Organopnictogen compound
Organic oxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

carbamate ester (CHEBI:34938 )
aromatic ether (CHEBI:34938 )
Carbamate insecticides (C14334 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

EC 3.1.1.7 (acetylcholinesterase) inhibitor (PMC10785821 )?An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
EC 3.1.1.8 (cholinesterase) inhibitor (PMC11834182 )?An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
carbamate insecticide (PMC3909396 )?
insecticide (PMC7799788 , PMC10785821 )?
inhibitor (PMC3836847 , PMC7188772 )?
pesticide (PMC10785821 )?
acaricide (PMC8292978 )?
molluscicide (PMC8292978 )?

Chemical Roles

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	87°C
Boiling Point	Not Available
Solubility	1.86 mg/mL at 20°C [BOWMAN,BT & SANS,WW (1983)]

Predicted Properties

Property	Value	Source
Water Solubility	0.71 g/L	ALOGPS
logP	1.97	ALOGPS
logP	2.09	ChemAxon
logS	-2.5	ALOGPS
pKa (Strongest Acidic)	14.76	ChemAxon
pKa (Strongest Basic)	-4.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	47.56 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	56.39 m³·mol⁻¹	ChemAxon
Polarizability	22.14 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0900000000-076909e40c1f06da265d	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00e9-9840000000-15726b4525320e58e336	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0900000000-0653e45a40325cf2566c	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03xv-9700000000-ab680708144f345b19d9	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-02t9-9200000000-c1d7672d90bded282acb	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0900000000-e7645160622a94187796	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0900000000-29e84e3b240eee0dc146	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-1900000000-fa425f04d84ea26b1162	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03dl-3900000000-bbe8468f2fe23ba875e9	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-03di-0900000000-b1804f2cc53b3311b368	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0w29-5940000000-a2b4e0a74c81f5ef01a9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-08fr-4900000000-4d2864ece79eb45d8158	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9200000000-d5814add203c851ea101	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9440000000-78d2a41a1f91cb8531d3	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9610000000-a33cf88332a92e007d32	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0a4i-9100000000-698cf7a9d385aba390c1	Not Available	View Spectrum
MS	MS Spectrum	splash10-03di-8900000000-b48959d55eb8491bb7e1	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
48.0 Log mg/kg [30:85]	Rat	LD50	oral	predicted	Not Available	Not Available
1.73 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.6 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
702.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
864.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1000.0 ppm	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
30.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.74 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
3750.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
25.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
30.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
17.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.1 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
3.4 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.851 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
20.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
30.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.74 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
702.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
90.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
40.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
702.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
90.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1000.0 ppm	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
30.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.0031 mmol/kg	European Rabbit	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.0125 mmol/kg	European Rabbit	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
8000.0 ppm	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
12.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.74 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
3.4 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.2 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.6 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.851 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
3.4 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
20.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
40.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
40.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.851 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.0031 mmol/kg	European Rabbit	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.3 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
3.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.73 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
8000.0 ppm	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.851 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.05 mmol/kg	European Rabbit	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
17.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
12.5 ppm	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
2000.0 mg/L	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
7.4 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.851 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
25.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.2 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
30.0 ppm	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
15.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
90.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.851 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
12.5 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
50.0 ppm	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
4.25 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.7 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
3.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
7.4 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.74 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
6.2 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.5 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.5 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.51 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2000.0 mg/L	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2000.0 mg/L	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
600.0 mg/L	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
17.52 mg/L	European Rabbit	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.76 mg/L	European Rabbit	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
17.52 mg/L	European Rabbit	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
8.76 mg/L	European Rabbit	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.1 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
3.4 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.0031 mmol/kg	European Rabbit	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
0.0125 mmol/kg	European Rabbit	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.9 mg/kg-day	Rat	BMD (50)	oral	experimental	Not Available	ECOTOX - EPA ORD
0.24 mg/kg-day	Rat	BMD (10)	oral	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.3 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
3.3 mg/kg-day	Rat	BMD (50)	oral	experimental	Not Available	ECOTOX - EPA ORD
3.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
0.55 mg/kg-day	Rat	BMD (10)	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Propoxur is a cholinesterase or acetylcholinesterase (AChE) inhibitor. Carbamates form unstable complexes with chlolinesterases by carbamoylation of the active sites of the enzymes. This inhibition is reversible. A cholinesterase inhibitor suppresses the action of acetylcholine esterase. Because of its essential function, chemicals that interfere with the action of acetylcholine esterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. Unlike organophosphate poisoning, carbamate poisonings tend to be of shorter duration because the inhibition of nervous tissue acetylcholinesterase is reversible, and carbamates are more rapidly metabolized. Muscle weakness, dizziness, sweating and slight body discomfort are commonly reported early symptoms. Headache, salivation, nausea, vomiting, abdominal pain and diarrhea are often prominent at higher levels of exposure. Contraction of the pupils with blurred vision, incoordination, muscle twitching and slurred speech have been reported. (3)

Treatment

If the compound has been ingested, rapid gastric lavage should be performed using 5% sodium bicarbonate. For skin contact, the skin should be washed with soap and water. If the compound has entered the eyes, they should be washed with large quantities of isotonic saline or water. In serious cases, atropine and/or pralidoxime should be administered. Anti-cholinergic drugs work to counteract the effects of excess acetylcholine and reactivate AChE. Atropine can be used as an antidote in conjunction with pralidoxime or other pyridinium oximes (such as trimedoxime or obidoxime), though the use of '-oximes' has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine is a muscarinic antagonist, and thus blocks the action of acetylcholine peripherally.

Health Effects

Health Effect	Relationship	Direction	Description	Reference
Oxidative Stress	Associated With?	Not Available	Not Available	PMC8230257 , PMC5963642
Mortality	Associated With?	Not Available	Not Available	PMC2359736

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000019	Indoor air?Indoor air can be a significant reservoir for synthetic chemical contaminants, which often originate from various sources within enclosed environments.	Air, dust & atmospheric transport	Not Available
CEDs000070	Stormwater runoff?Stormwater runoff refers to the flow of rainwater or melted snow that does not soak into the ground and instead collects pollutants as it travels over impervious surfaces such as roads and parking lots.	Automotive & urban infrastructure	PubChem
CEDs000115	Drinking water?Drinking water can be a medium for synthetic chemical contamination, often originating from various industrial processes and agricultural practices.	Drinking water & water supply	Not Available
CEDs000233	Brushes?Brushes used in personal care and cosmetics can be a source of synthetic chemical contamination due to the materials and coatings used in their manufacturing.	Personal care & cosmetics	PubChem
CEDs000456	Nylon?Nylon is a synthetic polymer, primarily composed of polyamide, created through the polymerization of amine and carboxylic acid monomers.	Textiles, leather & furnishings	PMC10048222
CEDs000503	Tents Or Canopies?Tents and canopies used in various applications can be a source of synthetic chemical contamination primarily due to the materials from which they are made.	Building & Construction	PubChem
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000516	Electric Hearing Aids?Electric hearing aids are small electronic devices designed to amplify sound for individuals with hearing loss.	Electrical & Electronic Equipment	PubChem
CEDs000517	Electric Switches?Electric switches, integral components in numerous devices, can be a source of synthetic chemical contamination due to the materials and manufacturing processes involved in their production.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000521	Fixed Capacitors And Their Manufacture?Fixed capacitors are passive electronic components used to store and release electrical energy, playing a critical role in various circuits.	Electrical & Electronic Equipment	PubChem
CEDs000525	Line Transmission Systems?Line Transmission Systems, commonly used for the distribution of electrical energy, can be a source of synthetic chemical contamination through the insulation materials and coatings utilized in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000527	Magnets?Magnets, commonly used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials used in their production.	Electrical & Electronic Equipment	PubChem
CEDs000530	Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.	Electrical & Electronic Equipment	PubChem
CEDs000533	Sparking Plugs?Spark plugs are critical components in internal combustion engines, facilitating the ignition of fuel-air mixtures by generating a spark.	Electrical & Electronic Equipment	PubChem
CEDs000537	Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.	Electrical & Electronic Equipment	PubChem
CEDs000538	Thin Magnetic Films?Thin magnetic films are layers of magnetic material ranging from a few nanometers to several micrometers in thickness, commonly used in applications such as magnetic sensors, data storage devices, and electronic components.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000547	Preparation Of Malt?Malt preparation involves the germination and drying of cereal grains, primarily barley, to produce malt for brewing and food products.	Food, food processing & cookware	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000563	Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.	Household cleaning & consumer products	PubChem
CEDs000564	Soap Dispensers?Soap dispensers, commonly used for dispensing liquid soaps and sanitizers, can become a source of synthetic chemical contamination due to the materials used in their construction and the products they dispense.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000578	Making Cigars?The process of making cigars involves several steps, including the cultivation of tobacco, fermentation, and the application of various additives to enhance flavor and preservation.	Industrial manufacturing & chemical processing	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000583	Anchoring Equipment?Anchoring equipment, commonly used in marine applications, can be a source of synthetic chemical contamination due to the materials and coatings utilized in their manufacturing.	Marine, shipping & aquaculture	PubChem
CEDs000592	Marine Propulsion Or Steering?Marine propulsion and steering systems often rely on various synthetic chemicals, including lubricants, fuels, and hydraulic fluids.	Marine, shipping & aquaculture	PubChem
CEDs000595	Ships?Ships, as vehicles for international trade and transportation, can be significant sources of synthetic chemical contamination in marine environments.	Marine, shipping & aquaculture	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000597	Chemosterilants?Chemosterilants are synthetic chemicals designed to induce sterility in target pest populations, thereby controlling their reproduction and mitigating damage to crops.	Agriculture & land management	PubChem
CEDs000598	Fertiliser Distributors?Fertiliser distributors play a critical role in the supply of synthetic fertilizers, which are widely used to enhance soil fertility and crop yield.	Agriculture & land management	PubChem
CEDs000600	Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.	Agriculture & land management	PubChem
CEDs000602	Molluscicides?Molluscicides are synthetic chemicals specifically designed to control and eliminate mollusks, such as snails and slugs, which can be detrimental to crops and agricultural productivity.	Agriculture & land management	PubChem
CEDs000603	Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.	Agriculture & land management	PubChem
CEDs000604	Pest Attractants?Pest attractants are synthetic chemicals designed to lure specific pests for monitoring or control purposes.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000606	Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.	Agriculture & land management	PubChem
CEDs000607	Rodenticides(1)?Rodenticides are synthetic chemicals specifically formulated to control rodent populations, serving as a crucial tool in managing pests that can damage crops and spread diseases.	Agriculture & land management	PubChem
CEDs000608	Rodenticides?Rodenticides are chemical substances specifically designed to control rodent populations by causing death through various mechanisms, including anticoagulation or neurotoxicity.	Agriculture & land management	PubChem
CEDs000609	Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.	Personal care & cosmetics	PubChem
CEDs000610	Aftersun Products?Aftersun products are designed to soothe and hydrate the skin after sun exposure, often containing various synthetic chemicals such as emollients, preservatives, and fragrances.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000617	Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000630	Toys?Toys, particularly those made from synthetic materials such as plastics, can be a source of chemical contamination due to the presence of various additives and compounds used in their production.	Recreation & sports surfaces	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000652	Ropes?Ropes manufactured from synthetic fibers, such as polypropylene, nylon, and polyester, are widely used in various applications, including marine, construction, and outdoor activities.	Textiles, leather & furnishings	PubChem
CEDs000658	Touch Fasteners?Touch fasteners, commonly known as hook-and-loop fasteners, are composed of synthetic materials such as nylon or polyester.	Textiles, leather & furnishings	PubChem
CEDs000662	Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.	Textiles, leather & furnishings	PubChem
CEDs000665	Fire Extinguishers?Fire extinguishers contain various synthetic chemicals designed to suppress flames and prevent the spread of fire.	Fire suppression systems & agents	PubChem
CEDs000667	Gaseous Fire Fighting?Gaseous fire fighting systems utilize synthetic chemicals, such as halocarbons and inert gases, to suppress fires through chemical and physical processes.	Fire suppression systems & agents	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000673	Unmanned Aerial Vehicles?Unmanned Aerial Vehicles (UAVs), commonly known as drones, utilize various synthetic chemicals in their manufacturing, operation, and maintenance processes.	Aviation & Aerospace	PubChem
CEDs000678	Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.	Agriculture & land management	PubChem
CEDs000679	Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.	Agriculture & land management	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000686	Clay Wares?Clay wares are ceramic products made from natural clay, often utilized in various construction applications such as tiles, bricks, and sanitary ware.	Building & Construction	PubChem
CEDs000693	Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000697	Submarines?Submarines, while essential for military and research purposes, can be a source of synthetic chemical contamination due to their use of various industrial chemicals.	Marine, shipping & aquaculture	PubChem
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	PubChem
CEDs000699	Mining Or Quarrying?Mining and quarrying operations can lead to synthetic chemical contamination through the release of various pollutants associated with the extraction and processing of minerals.	Mining & metal processing	PubChem
CEDs000701	Ventilation Of Mines Or Tunnels?Ventilation in mines or tunnels is essential for maintaining air quality and ensuring the safety of workers.	Mining & metal processing	PubChem
CEDs000727	Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.	Paper, pulp & fiber products	PubChem
CEDs000730	Contact Lens Cases?Contact lens cases are small containers designed to store contact lenses in a sterile environment, typically made from various synthetic materials including plastics such as polypropylene or polycarbonate.	Healthcare, pharmaceuticals & veterinary products	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000738	Cooling Circuit Water?Cooling circuit water is utilized in various industrial processes to absorb and dissipate heat generated during operations.	Industrial manufacturing & chemical processing	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000741	Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.	Paper, pulp & fiber products	PubChem
CEDs000742	Leather Tanning?Leather tanning is a process that transforms raw animal hides into durable leather through the application of various chemicals, including chromium salts, aldehydes, and vegetable tannins.	Textiles, leather & furnishings	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs01199	Honey Samples	Food, food processing & cookware	PMC9968705
CEDs01200	Vegetables	Food, food processing & cookware	PMC3909396
CEDs02264	Sediment	Aquatic systems & sediments	PMC10785821
CEDs02589	Air	Air, dust & atmospheric transport	PMC11185994
CEDs03047	Wastewater Treatment Plant Effluents	Wastewater, sanitation & biosolids	PMC3499860

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Acetylcholinesterase	K4JQ36	Laodelphax striatella	Predicted (SEA)	Prediction Confidence Score 0.421 Applicability Domain 0.579 Statistical Significance 1.00e-05 Supporting Reference Compounds 3 E-value 0.0778492
Click to view 3D structure	Ace-orthologous acetylcholinesterase	Q9NJH6	Nephotettix cincticeps	Predicted (SEA)	Prediction Confidence Score 0.362 Applicability Domain 0.579 Statistical Significance 2.00e-05 Supporting Reference Compounds 4 E-value 0.155698
Click to view 3D structure	Acetylcholinesterase	O42275	Electrophorus electricus	Predicted (SEA)	Prediction Confidence Score 0.32 Applicability Domain 0.556 Statistical Significance 0.0163 Supporting Reference Compounds 206 E-value 126.583
Click to view 3D structure	Transcription factor EB	P19484	Humans	Predicted (SEA)	Prediction Confidence Score 0.317 Applicability Domain 0.317 Statistical Significance 9.00e-04 Supporting Reference Compounds 1 E-value 7.00643
Click to view 3D structure	Acetylcholinesterase	Q7YWJ9	Musca domestica	Predicted (SEA)	Prediction Confidence Score 0.302 Applicability Domain 0.579 Statistical Significance 1.00e-05 Supporting Reference Compounds 5 E-value 0.0778492
Click to view 3D structure	Acetylcholinesterase	P23795	Bos taurus	Predicted (SEA)	Prediction Confidence Score 0.296 Applicability Domain 0.556 Statistical Significance 0.0035 Supporting Reference Compounds 50 E-value 27.3251
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Predicted (SEA)	Prediction Confidence Score 0.287 Applicability Domain 0.306 Statistical Significance 0.057 Supporting Reference Compounds 406 E-value 444.052
Click to view 3D structure	Acetylcholinesterase	P36196	Gallus gallus	Predicted (SEA)	Prediction Confidence Score 0.286 Applicability Domain 0.286 Low confidence Statistical Significance 4.40e-04 Supporting Reference Compounds 1 E-value 3.42537
Click to view 3D structure	Alpha-1A adrenergic receptor	P35348	Humans	Predicted (SEA)	Prediction Confidence Score 0.273 Applicability Domain 0.302 Statistical Significance 0.0712 Supporting Reference Compounds 376 E-value 554.598
Click to view 3D structure	Alpha-2C adrenergic receptor	P18825	Humans	Predicted (SEA)	Prediction Confidence Score 0.272 Applicability Domain 0.364 Statistical Significance 0.0637 Supporting Reference Compounds 386 E-value 496.055
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P19327	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.272 Applicability Domain 0.295 Low confidence Statistical Significance 0.1034 Supporting Reference Compounds 541 E-value 805.117
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.272 Applicability Domain 0.328 Statistical Significance 0.1634 Supporting Reference Compounds 955 E-value 1272.37
Click to view 3D structure	Beta-1 adrenergic receptor	P08588	Humans	Predicted (SEA)	Prediction Confidence Score 0.271 Applicability Domain 0.305 Statistical Significance 0.0272 Supporting Reference Compounds 180 E-value 211.672
Click to view 3D structure	Beta-3 adrenergic receptor	P13945	Humans	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.305 Statistical Significance 0.017 Supporting Reference Compounds 145 E-value 132.266
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.295 Low confidence Statistical Significance 0.1543 Supporting Reference Compounds 953 E-value 1200.9
Click to view 3D structure	Aryl hydrocarbon receptor	Q9YGV3	Danio rerio	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.383 Statistical Significance 2.10e-04 Supporting Reference Compounds 2 E-value 1.63483
Click to view 3D structure	Cholinesterase	P06276	Humans	Predicted (SEA)	Prediction Confidence Score 0.269 Applicability Domain 0.286 Low confidence Statistical Significance 0.0563 Supporting Reference Compounds 234 E-value 438.369
Click to view 3D structure	Alpha-2B adrenergic receptor	P18089	Humans	Predicted (SEA)	Prediction Confidence Score 0.269 Applicability Domain 0.364 Statistical Significance 0.0655 Supporting Reference Compounds 340 E-value 509.757
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.268 Applicability Domain 0.286 Low confidence Statistical Significance 0.2743 Supporting Reference Compounds 1130 E-value 2135.4
Click to view 3D structure	Beta-2 adrenergic receptor	P07550	Humans	Predicted (SEA)	Prediction Confidence Score 0.268 Applicability Domain 0.305 Statistical Significance 0.0441 Supporting Reference Compounds 258 E-value 343.004
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Predicted (SEA)	Prediction Confidence Score 0.265 Applicability Domain 0.306 Statistical Significance 0.0883 Supporting Reference Compounds 385 E-value 687.097
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Predicted (SEA)	Prediction Confidence Score 0.265 Applicability Domain 0.306 Statistical Significance 0.0682 Supporting Reference Compounds 310 E-value 531.087
Click to view 3D structure	Prostaglandin G/H synthase 1	P23219	Humans	Predicted (SEA)	Prediction Confidence Score 0.264 Applicability Domain 0.333 Statistical Significance 0.032 Supporting Reference Compounds 136 E-value 248.806
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Predicted (SEA)	Prediction Confidence Score 0.264 Applicability Domain 0.306 Statistical Significance 0.0867 Supporting Reference Compounds 373 E-value 674.953
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.263 Applicability Domain 0.277 Low confidence Statistical Significance 0.1302 Supporting Reference Compounds 593 E-value 1013.75
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Known	Not Available
Click to view 3D structure	Glutathione reductase	P06715	Escherichia coli (strain K12)	Known	Not Available
Click to view 3D structure	Glutathione S-transferase	Q59721	Burkholderia xenovorans (strain LB400)	Known	Not Available
Click to view 3D structure	Catalase	P04040	Humans	Known	Not Available
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Known	Not Available
Click to view 3D structure	Cholinesterase	P06276	Humans	Known	Like the organophosphates, their mode of action is inhibition of cholinesterase enzymes, affecting nerve impulse transmission. (L795)
Click to view 3D structure	C-C motif chemokine 2	P13500	Humans	Known	Not Available
Click to view 3D structure	Interstitial collagenase	P03956	Humans	Known	Not Available
Click to view 3D structure	Urokinase plasminogen activator surface receptor	Q03405	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2B6	P20813	Humans	Known	Not Available
Click to view 3D structure	Intercellular adhesion molecule 1	P05362	Humans	Known	Not Available
Click to view 3D structure	Interleukin-1 alpha	P01583	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

HMDB0256832

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Propoxur

Chemspider ID

4775

ChEBI ID

34938

PubChem Compound ID

Not Available

Kegg Compound ID

C14334

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Roldan-Tapia L, Nieto-Escamez FA, del Aguila EM, Laynez F, Parron T, Sanchez-Santed F: Neuropsychological sequelae from acute poisoning and long-term exposure to carbamate and organophosphate pesticides. Neurotoxicol Teratol. 2006 Nov-Dec;28(6):694-703. Epub 2006 Aug 30. [PubMed: 17029710]
IPCS Intox Database (1987). Antimony pentoxide. - http://www.intox.org/databank/documents/chemical/antpenta/ukpid36.htm
Fishel F (2009). Pesticide Toxicity Profile: Carbamate Pesticides. University of Florida, IFAS Extension. - http://edis.ifas.ufl.edu/PI088

Propoxur (CED0007131)

Structure for CHEM000862: Propoxur

No pathways found

Structure