Potassium permanganate (CED0002301)

Potassium permanganate is an exogenous inorganic compound with the formula H8KMnO4 and an average molecular weight of 166.10 g/mol. It exists as a solid at room temperature. Potassium permanganate belongs to the alkali metal oxides, a subclass of alkali metal organides within the inorganic compounds. In industrial applications, it is used as a biocide, emulsifier, anti-caking agent, and as processing aids not otherwise specified. It is also used in the production of Acrylonitrile butadiene styrene plastics. The compound is found in or released from 20 recorded sources, including electrical and electronic equipment such as magnets, cores yokes or armatures, antennas, communication cables or conductors, and electric hearing aids. Other sources include building and construction materials like fencing, ceilings, and tents or canopies; household cleaning and consumer products such as pipe accessories and non electric simulated smoking devices; food and cookware related to the processing of meats and the preparation of vinegar, wine, or sparkling wine; and healthcare products, including antiseptics and disinfectants and unclassified therapeutic products. The recorded exposure route is topical. Potassium permanganate has three recorded protein targets. It targets cytoplasmic aconitate hydratase (ACO1) and mitochondrial aconitate hydratase (ACO2), where manganese inhibits aconitase to interfere with amino acid metabolism and increase citrate levels; this disruption of the catalytic [4Fe-4S] cluster produces iron regulary protein 1, altering cellular iron homeostasis. It also targets an unnamed protein by stabilizing iron regulatory protein 2, which may occur through direct competition for an iron-binding site. Finally, it binds to the major prion protein (PRNP), displacing copper and altering the conformation and redox chemistry of the complex in ways similar to those associated with prion disease.