Methylcyclopentadienyl manganese tricarbonyl (CED0011938)

Methylcyclopentadienyl manganese tricarbonyl (C9H7MnO3) is an exogenous liquid with an average molecular weight of 218.09 g/mol. Methylcyclopentadienyl manganese tricarbonyl belongs to the olefins, a subclass of unsaturated hydrocarbons within the organic compounds. Industrially, the compound is used as a fuel additive (PMC4545267). The compound has been released from 22 recorded sources, including aquatic systems and sediments such as groundwater, surface water, seawater, and freshwater; drinking water and water supply including tap, bottled, and desalinated water; and wastewater, sanitation and biosolids including industrial wastewater, mine wastewater, and wastewater treatment effluent. It is also found in marine, shipping and aquaculture sources like bilge and ballast water, as well as electrical and electronic equipment such as television systems and amplifiers, and appliances including water heaters and water coolers. Recorded exposure routes include oral, inhalation, and touch. Methylcyclopentadienyl manganese tricarbonyl interacts with three recorded protein targets. It binds to the major prion protein (PRNP), displacing copper and altering the protein's conformation and the redox chemistry of the metal-protein complex in ways similar to those associated with prion disease. It also targets cytoplasmic aconitate hydratase (ACO1) and mitochondrial aconitate hydratase (ACO2), where manganese inhibits aconitase and disrupts the catalytic [4Fe-4S] cluster. This inhibition increases citrate levels and produces iron regulatory protein 1, altering cellular iron homeostasis. Additionally, manganese targets an unnamed protein, stabilizing iron regulatory protein 2 by competing for an iron-binding site, which disrupts the mechanisms responsible for its iron-dependent degradation.