Lead fluoride (CHEM001146)

Record Information
Version1.0
Creation Date2009-06-19 21:58:37 UTC
Update Date2026-08-17 20:38:14 UTC
Accession NumberCHEM001146
Identification
Common NameLead fluoride
ClassSmall Molecule
Description
Lead(II) fluoride is a fluoride of lead. It is used in certain types of glass, in phosphors for television-tube screens, and as a catalyst for the manufacture of picoline. Lead is a heavy metal and stable element with the symbol Pb and the atomic number 82, existing in metallic, organic, and inorganic forms. It is mainly found in nature as the mineral galena (PbS), cerussite (PbCO3) or anglesite (PbSO4), usually in ore with zinc, silver, or copper. (4, 8)
Contaminant Sources
  • Clean Air Act Chemicals
  • IARC Carcinogens Group 2A
  • T3DB toxins
Contaminant Type
  • Fluoride Compound
  • Human Neurotoxin
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Lead Compound
  • Pollutant
  • Synthetic Compound
Chemical Structure
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Lead fluoride (PBF2)MeSH
Lead fluoride (PBF3)MeSH
Lead(II) fluorideMeSH
Chemical FormulaF2Pb
Average Molecular Mass245.200 g/mol
Monoisotopic Mass245.973 g/mol
CAS Registry Number7783-46-2
IUPAC Namedifluoroplumbane
Traditional Namedifluoroplumbane
SMILESF[Pb]F
InChI IdentifierInChI=1S/2FH.Pb/h2*1H;/q;;+2/p-2
InChI KeyFPHIOHCCQGUGKU-UHFFFAOYSA-L
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as post-transition metal fluorides. These are inorganic compounds in which the largest halogen atom is fluorine, and the heaviest metal atom is a post-transition metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassPost-transition metal salts
Sub ClassPost-transition metal fluorides
Direct ParentPost-transition metal fluorides
Alternative Parents
Substituents
  • Post-transition metal fluoride
  • Inorganic lead salt
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting Point824°C
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
logP0.72ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity3 m³·mol⁻¹ChemAxon
Polarizability2.77 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Toxicity Profile
Route of ExposureOral (7) ; inhalation (7) ; dermal (7)
Mechanism of ToxicityLead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example, lead has been shown to competitively inhibit calcium's binding of calmodulin, interferring with neurotransmitter release. It exhibits similar competitive inhibition at the NMDA receptor and protein kinase C, which impairs brain microvascular formation and function, as well as alters the blood-brain barrier. Lead also affects the nervous system by impairing regulation of dopamine synthesis and blocking evoked release of acetylcholine. However, it's main mechanism of action occurs by inhibiting delta-aminolevulinic acid dehydratase, an enzyme vital in the biosynthesis of heme, which is a necesssary cofactor of hemoglobin. (9, 2, 3, 7)
MetabolismLead is absorbed following inhalation, oral, and dermal exposure. It is then distributed mainly to the bones and red blood cells. In the blood lead may be found bound to serum albumin or the metal-binding protein metallothionein. Organic lead is metabolized by cytochrome P-450 enzymes, whereas inorganic lead forms complexes with delta-aminolevulinic acid dehydratase. Lead is excreted mainly in the urine and faeces. (7)
Toxicity ValuesLD50: 3031 mg/kg (Oral, Rat) (10)
Lethal Dose10 to 30 grams for and adult human (lead salts). (11)
Carcinogenicity (IARC Classification)2A, probably carcinogenic to humans. (6)
Uses/SourcesLead(II) fluoride is used in certain types of glass, in phosphors for television-tube screens, and as a catalyst for the manufacture of picoline. (8)
Minimum Risk LevelChronic Inhalation: 0.05 mg/m3 (5)
Health EffectsLead is a neurotoxin and has been known to cause brain damage and reduced cognitive capacity, especially in children. Lead exposure can result in nephropathy, as well as blood disorders such as high blood pressure and anemia. Lead also exhibits reproductive toxicity and can results in miscarriages and reduced sperm production. (4)
SymptomsSymptions of chronic lead poisoning include reduced cognitive abilities, nausea, abdominal pain, irritability, insomnia, metal taste in the mouth, excess lethargy or hyperactivity, chest pain, headache and, in extreme cases, seizures, comas, and death. There are also associated gastrointestinal problems, such as constipation, diarrhea, vomiting, poor appetite, weight loss, which are common in acute poisoning. (1, 4)
TreatmentLead poisoning is usually treated with chelation therapy using DMSA, EDTA, or dimercaprol. (4)
Concentrations
Not Available
External Links
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkLead fluoride
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound ID24549
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General References