Zinc dimethyldithiocarbamate (CED0009896)

Record Information

Version

1.0

Creation Date

2009-06-19 21:58:49 UTC

Update Date

2026-04-05 15:31:29 UTC

SynCED ID

CED0009896

Secondary Accession Numbers

CHEM001250
T3D1465

Identification

Common Name

Zinc dimethyldithiocarbamate

Class

Small Molecule

Description

Zinc dimethyldithiocarbamate is an exogenous chemical compound with the formula C6H12N2S4Zn and an average molecular weight of 305.84 g/mol. It is a solid at room temperature. Zinc dimethyldithiocarbamate belongs to the organic transition metal salts, a subclass of organic metal salts within the organic compounds. Industrially, the compound is utilized as a catalyst, a chemical reaction regulator, and a biocide. It has been released from 18 recorded sources, including drinking water, soap detergents, and perfumes within detergents and soaps. Other sources include food processing activities such as food preservation, processing meats, and the preparation of malt. Additionally, it is found in building and construction materials like floors, fencing, and tents or canopies, as well as electrical and electronic equipment, including antennas, communication cables or conductors, electrodes, adjustable resistors, and conductive bodies characterized by the conductive materials. The recorded exposure route for this compound is oral. It interacts with seven recorded protein targets, including the insulin receptor (INSR), the glucocorticoid receptor (NR3C1), tyrosine-protein phosphatase non-receptor type 1 (PTPN1), and cellular tumor antigen p53 (TP53). One of its targets is Cu,Zn-superoxide dismutase (SOD1); unbalanced levels of copper and zinc binding to this protein has been linked to amyotrophic lateral sclerosis (ALS).

Contaminant Type

Amine
Carbamate
Household Toxin
Industrial/Workplace Toxin
Organic Compound
Organometallic
Pesticide
Synthetic Compound
Zinc Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(T-4)-Bis(dimethylcarbamodithioato-kappas,kappas')zinc	ChEBI
Bis(dimethylcarbamodithioato-S,s')zinc	ChEBI
Bis(dimethyldithiocarbamato)zinc	ChEBI
Bis-dimethyldithiocarbamate de zinc	ChEBI
Dimethyldithiocarbamate zinc salt	ChEBI
Zinc bis(dimethyldithiocarbamate)	ChEBI
Zinc bis(dimethyldithiocarbamoyl)disulphide	ChEBI
Zinc bis(dimethylthiocarbamoyl)disulfide	ChEBI
Bis-dimethyldithiocarbamic acid de zinc	Generator
Dimethyldithiocarbamic acid zinc salt	Generator
Zinc bis(dimethyldithiocarbamic acid)	Generator
Zinc bis(dimethyldithiocarbamoyl)disulfide	Generator
Zinc bis(dimethylthiocarbamoyl)disulphide	Generator
Zinc dimethyldithiocarbamic acid	Generator
Milbam	MeSH
Fuklasin	MeSH
Cuman L	MeSH
Dimethyldithiocarbamate, zinc	MeSH
Zerlate	MeSH

Chemical Formula

C₆H₁₂N₂S₄Zn

Average Molecular Mass

305.842 g/mol

Monoisotopic Mass

303.917 g/mol

CAS Registry Number

137-30-4

IUPAC Name

bis[(dimethylcarbamothioyl)sulfanyl]zinc

Traditional Name

ziram

SMILES

CN(C)C(=S)S[Zn]SC(=S)N(C)C

InChI Identifier

InChI=1S/2C3H7NS2.Zn/c2*1-4(2)3(5)6;/h2*1-2H3,(H,5,6);/q;;+2/p-2

InChI Key

DUBNHZYBDBBJHD-UHFFFAOYSA-L

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as organic transition metal salts. These are organic salt compounds containing a transition metal atom in its ionic form.

Kingdom

Organic compounds

Super Class

Organic salts

Class

Organic metal salts

Sub Class

Organic transition metal salts

Direct Parent

Organic transition metal salts

Alternative Parents

Substituents

Organic transition metal salt
Organic nitrogen compound
Organopnictogen compound
Hydrocarbon derivative
Organosulfur compound
Organonitrogen compound
Aliphatic acyclic compound

Molecular Framework

Not Available

External Descriptors

zinc molecular entity (CHEBI:79736 )
dithiocarbamate salt (CHEBI:79736 )
Dithiocarbamate fungicides (C15229 )
Dithiocarbamate pesticides (C15229 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

pesticide (PMC12150391 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White crystals.

Experimental Properties

Property	Value
Melting Point	250°C
Boiling Point	Not Available
Solubility	0.065 mg/mL at 25°C [GUNTHER,FA et al. (1968)]

Predicted Properties

Property	Value	Source
Water Solubility	0.12 g/L	ALOGPS
logP	1.86	ALOGPS
logP	1.74	ChemAxon
logS	-3.4	ALOGPS
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	6.48 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	69.24 m³·mol⁻¹	ChemAxon
Polarizability	26.56 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-0139000000-e6dfbc43c92ba0245ebe	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-000i-9100000000-c9631804bff9f34036cb	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-014r-9750000000-18a89bf261bf4687dd26	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0udi-3119000000-93b3e9f8d240e91db696	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0uy0-9625000000-08c5f6307170a4d62ca7	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-014r-7971000000-d0912a64c40ba4d2c93a	Not Available	View Spectrum
MS	MS Spectrum	splash10-0k9i-6539000000-4cf7031e44557fbc7ee3	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
18.0 mg/kg	Mouse	LD50	Intravenous	experimental	Not Available	7
23.0 mg/kg	Rat	LD50	Intraperitoneal	experimental	Not Available	7
320.0 mg/kg	Rat	LD50	Oral	experimental	Not Available	8
81.0 mg/m3	Rat	LC50	Inhalation (4 hours)	experimental	Not Available	7
0.12 mmol/kg	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.08 mmol/kg	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
12.5 mg/kg-day	Rat	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
50.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
20.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
50.0 ul/org	Mouse	LOEL	dermal	experimental	Not Available	ECOTOX - EPA ORD
1.0 mmol/kg	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
4.16 mmol/kg	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
2.08 mmol/kg	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
20.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Rat	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mmol/kg	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
50.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
25.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
10.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Mouse	NOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
25.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
1.0 mmol/kg	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
25.0 mg/kg-day	Mouse	LOEL	injection	experimental	Not Available	ECOTOX - EPA ORD
25.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
350.0 mg/kg-day	Mouse	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.56 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
16.146 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
1.56 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
111.0 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
12.5 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
9.5 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
46.8 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
111.0 mg/kg-day	Mouse	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
46.8 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
5.0 mg/kg-day	Rat	LOEL	oral	experimental	Not Available	ECOTOX - EPA ORD
4.0 mg/kg-day	Rat	NOEL	oral	experimental	Not Available	ECOTOX - EPA ORD

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (2, 3, 1)

Carcinogenicity (IARC Classification)

3, not classifiable as to its carcinogenicity to humans. (6)

Minimum Risk Level

Intermediate Oral: 0.3 mg/kg/day (5) Chronic Oral: 0.3 mg/kg/day (5)

Symptoms

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (3)

Treatment

Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (3)

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000070	Stormwater runoff?Stormwater runoff refers to the flow of rainwater or melted snow that does not soak into the ground and instead collects pollutants as it travels over impervious surfaces such as roads and parking lots.	Automotive & urban infrastructure	PubChem
CEDs000115	Drinking water?Drinking water can be a medium for synthetic chemical contamination, often originating from various industrial processes and agricultural practices.	Drinking water & water supply	Not Available
CEDs000181	Ballast water?Ballast water, taken on by ships to maintain stability and balance, often contains a diverse array of microorganisms, including bacteria, viruses, and plankton.	Marine, shipping & aquaculture	PubChem
CEDs000182	Bilge water?Bilge water is a byproduct generated from the accumulation of water in the lowest part of a ship's hull, which may include a mixture of seawater, oil, fuel residues, and various contaminants.	Marine, shipping & aquaculture	PubChem
CEDs000233	Brushes?Brushes used in personal care and cosmetics can be a source of synthetic chemical contamination due to the materials and coatings used in their manufacturing.	Personal care & cosmetics	PubChem
CEDs000496	Fencing?Fencing materials, particularly those used in construction and landscaping, can be a source of synthetic chemical contamination due to the treatments and coatings applied for durability and weather resistance.	Building & Construction	PubChem
CEDs000497	Floors?Floors in built environments can be a significant source of synthetic chemical contamination due to the materials and finishes used in their construction.	Building & Construction	PubChem
CEDs000503	Tents Or Canopies?Tents and canopies used in various applications can be a source of synthetic chemical contamination primarily due to the materials from which they are made.	Building & Construction	PubChem
CEDs000504	Adjustable Resistors?Adjustable resistors, commonly used in various electronic devices, can contribute to synthetic chemical contamination through the materials and substances used in their manufacturing and disposal.	Electrical & Electronic Equipment	PubChem
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000510	Communication Cables Or Conductors?Communication cables or conductors are essential components in the transmission of data and signals in various applications, including telecommunications and networking.	Electrical & Electronic Equipment	PubChem
CEDs000511	Conductors Or Conductive Bodies Characterised By The Conductive Materials?Conductors, or conductive bodies, are materials that allow the flow of electrical current, typically made from metals such as copper, aluminum, or silver.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000524	Hybrid Capacitors?Hybrid capacitors are energy storage devices that combine the properties of electrolytic and supercapacitors, utilizing a combination of electrochemical principles to achieve higher energy density and power density.	Electrical & Electronic Equipment	PubChem
CEDs000529	Power Cables?Power cables are used to transmit electrical energy and are typically composed of conductive materials, insulation, and protective coatings.	Electrical & Electronic Equipment	PubChem
CEDs000531	Relays?Relays are electromechanical switches used to control circuits and manage electrical loads.	Electrical & Electronic Equipment	PubChem
CEDs000537	Television Systems?Television systems can be a source of synthetic chemical contamination due to the various materials and components used in their manufacture and operation.	Electrical & Electronic Equipment	PubChem
CEDs000539	Video Games?Video games, through their production and disposal processes, can be a source of synthetic chemical contamination.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000547	Preparation Of Malt?Malt preparation involves the germination and drying of cereal grains, primarily barley, to produce malt for brewing and food products.	Food, food processing & cookware	PubChem
CEDs000552	Processing Meats?Processing meats can lead to synthetic chemical contamination primarily through the use of additives and preservatives.	Food, food processing & cookware	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000563	Soap Detergents?Soap detergents are synthetic surfactants designed to enhance the cleaning efficacy of water by reducing surface tension, allowing for better interaction with dirt and grease.	Household cleaning & consumer products	PubChem
CEDs000581	Paper Making Machines?Paper making machines utilize various synthetic chemicals throughout the production process, including additives, coatings, and bleaching agents.	Industrial manufacturing & chemical processing	PubChem
CEDs000583	Anchoring Equipment?Anchoring equipment, commonly used in marine applications, can be a source of synthetic chemical contamination due to the materials and coatings utilized in their manufacturing.	Marine, shipping & aquaculture	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000597	Chemosterilants?Chemosterilants are synthetic chemicals designed to induce sterility in target pest populations, thereby controlling their reproduction and mitigating damage to crops.	Agriculture & land management	PubChem
CEDs000598	Fertiliser Distributors?Fertiliser distributors play a critical role in the supply of synthetic fertilizers, which are widely used to enhance soil fertility and crop yield.	Agriculture & land management	PubChem
CEDs000600	Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.	Agriculture & land management	PubChem
CEDs000602	Molluscicides?Molluscicides are synthetic chemicals specifically designed to control and eliminate mollusks, such as snails and slugs, which can be detrimental to crops and agricultural productivity.	Agriculture & land management	PubChem
CEDs000603	Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.	Agriculture & land management	PubChem
CEDs000604	Pest Attractants?Pest attractants are synthetic chemicals designed to lure specific pests for monitoring or control purposes.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000606	Plant Growth Regulators?Plant Growth Regulators (PGRs) are synthetic chemicals designed to influence the growth and development of plants.	Agriculture & land management	PubChem
CEDs000607	Rodenticides(1)?Rodenticides are synthetic chemicals specifically formulated to control rodent populations, serving as a crucial tool in managing pests that can damage crops and spread diseases.	Agriculture & land management	PubChem
CEDs000608	Rodenticides?Rodenticides are chemical substances specifically designed to control rodent populations by causing death through various mechanisms, including anticoagulation or neurotoxicity.	Agriculture & land management	PubChem
CEDs000609	Aftershave?Aftershave is a grooming product typically used to soothe and protect the skin following shaving.	Personal care & cosmetics	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000613	Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.	Personal care & cosmetics	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000617	Lip Care Products?Lip care products, including lipsticks, balms, and glosses, often contain a variety of synthetic chemicals such as parabens, phthalates, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000619	Manicure Pedicure?Manicure and pedicure procedures often involve the use of various synthetic chemicals, including solvents, nail polishes, and nail adhesives.	Personal care & cosmetics	PubChem
CEDs000630	Toys?Toys, particularly those made from synthetic materials such as plastics, can be a source of chemical contamination due to the presence of various additives and compounds used in their production.	Recreation & sports surfaces	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000643	Headwear?Headwear made from synthetic materials often incorporates chemicals used in the manufacturing and finishing processes, such as dyes, flame retardants, and water repellents.	Textiles, leather & furnishings	PubChem
CEDs000652	Ropes?Ropes manufactured from synthetic fibers, such as polypropylene, nylon, and polyester, are widely used in various applications, including marine, construction, and outdoor activities.	Textiles, leather & furnishings	PubChem
CEDs000662	Yarns Or Threads?Yarns or threads used in textiles can be a source of synthetic chemical contamination due to the production processes and treatments they undergo.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000672	Light Than Air Aircraft?Light than air aircraft, such as dirigibles and airships, utilize lifting gases like helium or hydrogen for buoyancy.	Aviation & Aerospace	PubChem
CEDs000673	Unmanned Aerial Vehicles?Unmanned Aerial Vehicles (UAVs), commonly known as drones, utilize various synthetic chemicals in their manufacturing, operation, and maintenance processes.	Aviation & Aerospace	PubChem
CEDs000678	Nitrogenous Fertilisers?Nitrogenous fertilizers are synthetic chemical compounds primarily used to enhance plant growth by supplying essential nitrogen, a crucial nutrient for photosynthesis and protein synthesis.	Agriculture & land management	PubChem
CEDs000679	Phosphatic Fertilisers?Phosphatic fertilizers are synthetic chemical products primarily composed of phosphorus, which is essential for plant growth.	Agriculture & land management	PubChem
CEDs000684	Cements?Cements are a composite material primarily used as a binding agent in construction applications, formed by the calcination of limestone and clay minerals at high temperatures.	Building & Construction	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000686	Clay Wares?Clay wares are ceramic products made from natural clay, often utilized in various construction applications such as tiles, bricks, and sanitary ware.	Building & Construction	PubChem
CEDs000688	Glass Coatings?Glass coatings are synthetic chemical formulations applied to glass surfaces to enhance properties such as durability, UV resistance, and aesthetic appeal.	Building & Construction	PubChem
CEDs000693	Silica Glass?Silica glass, primarily composed of silicon dioxide (SiO2), is widely used in various applications, including windows, glass facades, and insulation materials.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000727	Printing Machines Or Presses?Printing machines or presses commonly utilize synthetic chemicals such as inks, solvents, and cleaning agents.	Paper, pulp & fiber products	PubChem
CEDs000733	Walking Sticks?Walking sticks, while primarily designed for mobility assistance, can be sources of synthetic chemical contamination if not properly manufactured or maintained.	Healthcare, pharmaceuticals & veterinary products	PubChem
CEDs000734	Coating Compositions?Coating compositions, which include paints, sealants, and varnishes, are formulated with a variety of synthetic chemicals such as solvents, resins, pigments, and additives.	Building & Construction	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000738	Cooling Circuit Water?Cooling circuit water is utilized in various industrial processes to absorb and dissipate heat generated during operations.	Industrial manufacturing & chemical processing	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000741	Pigment Pastes?Pigment pastes are concentrated dispersions of pigments used to impart color and properties to materials.	Paper, pulp & fiber products	PubChem
CEDs000742	Leather Tanning?Leather tanning is a process that transforms raw animal hides into durable leather through the application of various chemicals, including chromium salts, aldehydes, and vegetable tannins.	Textiles, leather & furnishings	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs01724	Wine Grapes	Food, food processing & cookware	PMC7448057

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Monoglyceride lipase	Q99685	Humans	Predicted (SEA)	Prediction Confidence Score 0.302 Applicability Domain 0.526 Statistical Significance 0.0045 Supporting Reference Compounds 76 E-value 34.7208
Click to view 3D structure	Carbamate kinase	O97438	Giardia intestinalis	Predicted (SEA)	Prediction Confidence Score 0.28 Applicability Domain 0.28 Low confidence Statistical Significance 2.00e-05 Supporting Reference Compounds 1 E-value 0.155698
Click to view 3D structure	Fructose-1,6-bisphosphatase 1	P09467	Humans	Predicted (SEA)	Prediction Confidence Score 0.267 Applicability Domain 0.526 Statistical Significance 0.0084 Supporting Reference Compounds 28 E-value 65.6269
Click to view 3D structure	Aldehyde dehydrogenase 1A1	P00352	Humans	Predicted (SEA)	Prediction Confidence Score 0.254 Applicability Domain 0.526 Statistical Significance 0.0043 Supporting Reference Compounds 31 E-value 33.3973
Click to view 3D structure	Replicase polyprotein 1ab	P0DTD1	SARS-CoV-2	Predicted (SEA)	Prediction Confidence Score 0.243 Applicability Domain 0.526 Statistical Significance 0.0771 Supporting Reference Compounds 215 E-value 600.607
Click to view 3D structure	Gasdermin-D	P57764	Humans	Predicted (SEA)	Prediction Confidence Score 0.236 Applicability Domain 0.28 Low confidence Statistical Significance 6.00e-05 Supporting Reference Compounds 2 E-value 0.467095
Click to view 3D structure	Gasdermin-D	Q9D8T2	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.236 Applicability Domain 0.28 Low confidence Statistical Significance 6.00e-05 Supporting Reference Compounds 2 E-value 0.467095
Click to view 3D structure	Histone-lysine N-methyltransferase EHMT2	Q96KQ7	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.526 Statistical Significance 0.0592 Supporting Reference Compounds 52 E-value 461.179
Click to view 3D structure	Aldehyde dehydrogenase, mitochondrial	P05091	Humans	Predicted (SEA)	Prediction Confidence Score 0.223 Applicability Domain 0.526 Statistical Significance 0.0074 Supporting Reference Compounds 24 E-value 57.842
Click to view 3D structure	Lysyl oxidase homolog 2	Q9Y4K0	Humans	Predicted (SEA)	Prediction Confidence Score 0.199 Applicability Domain 0.526 Statistical Significance 0.0585 Supporting Reference Compounds 26 E-value 455.807
Click to view 3D structure	Protein-lysine 6-oxidase	P28300	Humans	Predicted (SEA)	Prediction Confidence Score 0.194 Applicability Domain 0.526 Statistical Significance 0.0213 Supporting Reference Compounds 17 E-value 165.741
Click to view 3D structure	D-3-phosphoglycerate dehydrogenase	O43175	Humans	Predicted (SEA)	Prediction Confidence Score 0.194 Applicability Domain 0.28 Low confidence Statistical Significance 0.0084 Supporting Reference Compounds 12 E-value 65.1598
Click to view 3D structure	Histone-lysine N-methyltransferase EHMT1	Q9H9B1	Humans	Predicted (SEA)	Prediction Confidence Score 0.189 Applicability Domain 0.526 Statistical Significance 0.0949 Supporting Reference Compounds 26 E-value 739.101
Click to view 3D structure	Lysyl oxidase homolog 4	Q96JB6	Humans	Predicted (SEA)	Prediction Confidence Score 0.186 Applicability Domain 0.526 Statistical Significance 1.10e-04 Supporting Reference Compounds 5 E-value 0.856341
Click to view 3D structure	Lysyl oxidase homolog 3	P58215	Humans	Predicted (SEA)	Prediction Confidence Score 0.181 Applicability Domain 0.526 Statistical Significance 0.0263 Supporting Reference Compounds 12 E-value 204.821
Click to view 3D structure	Tyrosine-protein kinase JAK2	O60674	Humans	Predicted (SEA)	Prediction Confidence Score 0.174 Applicability Domain 0.526 Statistical Significance 0.9613 Supporting Reference Compounds 1022 E-value 7484.03
Click to view 3D structure	E3 ubiquitin-protein ligase Mdm2	Q00987	Humans	Predicted (SEA)	Prediction Confidence Score 0.16 Applicability Domain 0.526 Statistical Significance 0.6497 Supporting Reference Compounds 50 E-value 5057.63
Click to view 3D structure	Replicase polyprotein 1ab	K9N7C7	Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012)	Predicted (SEA)	Prediction Confidence Score 0.153 Applicability Domain 0.526 Statistical Significance 0.5253 Supporting Reference Compounds 48 E-value 4089.34
Click to view 3D structure	Photosystem II protein D1	P06402	Marchantia polymorpha	Predicted (SEA)	Prediction Confidence Score 0.137 Applicability Domain 0.143 Low confidence Statistical Significance 0.2281 Supporting Reference Compounds 2 E-value 1776.05
Click to view 3D structure	C-X-C chemokine receptor type 2	P25025	Humans	Predicted (SEA)	Prediction Confidence Score 0.136 Applicability Domain 0.28 Low confidence Statistical Significance 0.8785 Supporting Reference Compounds 40 E-value 6839.21
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	Prediction Confidence Score 0.133 Applicability Domain 0.28 Low confidence Statistical Significance 0.9979 Supporting Reference Compounds 1103 E-value 7768.42
Click to view 3D structure	Cholinesterase	P06276	Humans	Predicted (SEA)	Prediction Confidence Score 0.133 Applicability Domain 0.154 Low confidence Statistical Significance 0.9912 Supporting Reference Compounds 234 E-value 7716.26
Click to view 3D structure	Kappa-type opioid receptor	P41145	Humans	Predicted (SEA)	Prediction Confidence Score 0.132 Applicability Domain 0.28 Low confidence Statistical Significance 0.9982 Supporting Reference Compounds 532 E-value 7771.14
Click to view 3D structure	D(1A) dopamine receptor	P21728	Humans	Predicted (SEA)	Prediction Confidence Score 0.132 Applicability Domain 0.28 Low confidence Statistical Significance 0.9955 Supporting Reference Compounds 425 E-value 7749.73
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	Prediction Confidence Score 0.131 Applicability Domain 0.28 Low confidence Statistical Significance 0.9978 Supporting Reference Compounds 861 E-value 7767.72
Click to view 3D structure	Superoxide dismutase [Cu-Zn]	P00441	Humans	Known	Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). (A49)
Click to view 3D structure	Aromatase	P11511	Humans	Known	Not Available
Click to view 3D structure	Cellular tumor antigen p53	P04637	Humans	Known	Not Available
Click to view 3D structure	Tyrosine-protein phosphatase non-receptor type 1	P18031	Humans	Known	Not Available
Click to view 3D structure	Glucocorticoid receptor	P04150	Humans	Known	Not Available
Click to view 3D structure	Insulin receptor	P06213	Humans	Known	Not Available
Click to view 3D structure	Peroxisome proliferator-activated receptor gamma	P37231	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Ziram

Chemspider ID

Not Available

ChEBI ID

79736

PubChem Compound ID

8722

Kegg Compound ID

C15229

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Vonk WI, Klomp LW: Role of transition metals in the pathogenesis of amyotrophic lateral sclerosis. Biochem Soc Trans. 2008 Dec;36(Pt 6):1322-8. doi: 10.1042/BST0361322. [PubMed: 19021549]
Wikipedia. Zinc. Last Updated 24 March 2009. - http://en.wikipedia.org/wiki/Zinc
ATSDR - Agency for Toxic Substances and Disease Registry (2005). Toxicological profile for zinc. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). - http://www.atsdr.cdc.gov/toxprofiles/tp60.html
Wikipedia. Metallothionein. Last Updated 20 December 2008. - http://en.wikipedia.org/wiki/Metallothionein
ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). - http://www.atsdr.cdc.gov/mrls/
International Agency for Research on Cancer (2014). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. - http://monographs.iarc.fr/index.php
Lewis RJ (1996). Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold.
Tomlin CDS (ed) (1994). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council.

Zinc dimethyldithiocarbamate (CED0009896)

Structure for CHEM001250: Zinc dimethyldithiocarbamate

No pathways found

Structure