Silver acetylide (CED0009873)

Record Information

Version

1.0

Creation Date

2009-06-19 21:59:01 UTC

Update Date

2026-04-06 11:45:58 UTC

SynCED ID

CED0009873

Secondary Accession Numbers

CHEM001364
T3D1600

Identification

Common Name

Silver acetylide

Class

Small Molecule

Description

Silver acetylide is an exogenous organic compound with the formula C2HAg and an average molecular weight of 132.90 g/mol. It exists as a solid at room temperature. Silver acetylide belongs to the acetylides, a superclass within the organic compounds. The compound interacts with 16 recorded protein targets. The silver ion inhibits the activity of NA+,K+-ATPase, which disrupts intracellular ion concentrations; affected proteins include the sodium/potassium-transporting ATPase subunit gamma (FXYD2), sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1), sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2), sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3), and four other proteins. Additionally, the silver ion inhibits glutathione peroxidase activity, thereby disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. The proteins involved in this process include epididymal secretory glutathione peroxidase (GPX5), glutathione peroxidase 1 (GPX1), glutathione peroxidase 2 (GPX2), glutathione peroxidase 3 (GPX3), and four other proteins.

Contaminant Type

Industrial/Workplace Toxin
Organic Compound
Organometallic
Silver Compound
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Chemical Formula

C₂HAg

Average Molecular Mass

132.898 g/mol

Monoisotopic Mass

131.913 g/mol

CAS Registry Number

7659-31-6

IUPAC Name

ethynylsilver

Traditional Name

ethynylsilver

SMILES

[Ag]C#C

InChI Identifier

InChI=1S/C2H.Ag/c1-2;/h1H;

InChI Key

IHHLODLYMNGWGQ-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as acetylides. Acetylides are compounds arising by replacement of one or both hydrogen atoms of acetylene (ethyne) by a metal or other cationic group. E.G. NaC#CH monosodium acetylide. By extension, analogous compounds derived from terminal acetylenes, RC#CH. The class is limited here to derivatives of acetylene where the hydrogen atom is replaced with an element with similar or lower electronegativity that carbon.

Kingdom

Organic compounds

Super Class

Acetylides

Class

Not Available

Sub Class

Not Available

Direct Parent

Acetylides

Alternative Parents

Substituents

Acetylide
Hydrocarbon derivative
Organic silver salt
Organosilver compound
Organic salt
Organometallic compound
Organic transition metal moeity
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Not Available

Predicted Properties

Property	Value	Source
Water Solubility	2.1 g/L	ALOGPS
logP	-0.49	ALOGPS
logP	-0.52	ChemAxon
logS	-1.8	ALOGPS
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	6.98 m³·mol⁻¹	ChemAxon
Polarizability	4.93 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-6c1e66c2cff4571a3c9c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-6c1e66c2cff4571a3c9c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-6c1e66c2cff4571a3c9c	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-205600effcbb71442753	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-205600effcbb71442753	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-0900000000-205600effcbb71442753	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions and intracellular ion concentrations, respectively. Silver nanoparticles are believed to disrupt the mitochondrial respiratory chain, causing oxidative stress, reduced ATP synthesis, and DNA damage. (5, 1, 2, 3, 4)

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Exposure to high levels of silver for a long period of time may result in a condition called arygria, a blue-gray discoloration of the skin and other body tissues. Argyria is a permanent effect but does not appear to be harmful to health. Exposure to high levels of silver in the air has resulted in breathing problems, lung and throat irritation, and stomach pains. Skin contact with silver can cause mild allergic reactions such as rash, swelling, and inflammation in some people. (5)

Treatment

Not Available

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000517	Electric Switches?Electric switches, integral components in numerous devices, can be a source of synthetic chemical contamination due to the materials and manufacturing processes involved in their production.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000520	Emergency Protective Devices?Emergency protective devices, such as circuit breakers and surge protectors, are essential components in electrical systems designed to prevent damage from overcurrent and surges.	Electrical & Electronic Equipment	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000736	Fuses?Fuses are safety devices designed to protect electrical circuits by breaking the circuit when excessive current flows through.	Electrical & Electronic Equipment	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000740	Paper?Paper production involves the processing of wood fibers and the use of various chemicals, which can lead to synthetic chemical contamination.	Paper, pulp & fiber products	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem

Pathways

0 pathwaysPathway Source: PathBank

No pathways found

No metabolic pathways have been associated with this synthetic chemical

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Amine oxidase [flavin-containing] A	P21397	Humans	Predicted (SEA)	Prediction Confidence Score 0.095 Applicability Domain 0.111 Low confidence Statistical Significance 0.9997 Supporting Reference Compounds 241 E-value 7782.35
Click to view 3D structure	Cytochrome P450 2B1	P00176	Rat	Predicted (SEA)	Prediction Confidence Score 0.093 Applicability Domain 0.13 Low confidence Statistical Significance 0.6327 Supporting Reference Compounds 8 E-value 4925.29
Click to view 3D structure	Amine oxidase [flavin-containing] A	P21396	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.09 Applicability Domain 0.111 Low confidence Statistical Significance 0.9987 Supporting Reference Compounds 66 E-value 7774.49
Click to view 3D structure	Amine oxidase [flavin-containing] B	P19643	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.09 Applicability Domain 0.111 Low confidence Statistical Significance 0.9985 Supporting Reference Compounds 77 E-value 7773.63
Click to view 3D structure	Carbonic anhydrase 12	O43570	Humans	Predicted (SEA)	Prediction Confidence Score 0.079 Applicability Domain 0.125 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 332 E-value 7784.53
Click to view 3D structure	Carbonic anhydrase 1	P00915	Humans	Predicted (SEA)	Prediction Confidence Score 0.079 Applicability Domain 0.125 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 407 E-value 7784.84
Click to view 3D structure	Pyridoxine-5'-phosphate oxidase	Q9NVS9	Humans	Predicted (SEA)	Prediction Confidence Score 0.077 Applicability Domain 0.077 Low confidence Statistical Significance 0.7608 Supporting Reference Compounds 1 E-value 5922.61
Click to view 3D structure	Sigma intracellular receptor 2	Q8VD00	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.077 Applicability Domain 0.077 Low confidence Statistical Significance 0.6332 Supporting Reference Compounds 1 E-value 4929.1
Click to view 3D structure	Acetylcholinesterase	P22303	Humans	Predicted (SEA)	Prediction Confidence Score 0.074 Applicability Domain 0.091 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 406 E-value 7784.53
Click to view 3D structure	Cholinesterase	P06276	Humans	Predicted (SEA)	Prediction Confidence Score 0.07 Applicability Domain 0.091 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 234 E-value 7784.38
Click to view 3D structure	Adenosine receptor A2a	P30543	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.068 Applicability Domain 0.081 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 174 E-value 7784.38
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.066 Applicability Domain 0.075 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 593 E-value 7784.61
Click to view 3D structure	3-ketoacyl-CoA synthase 18	Q38860	Arabidopsis thaliana	Predicted (SEA)	Prediction Confidence Score 0.065 Applicability Domain 0.13 Low confidence Statistical Significance 0.782 Supporting Reference Compounds 2 E-value 6087.58
Click to view 3D structure	Pyrroline-5-carboxylate reductase 1, mitochondrial	P32322	Humans	Predicted (SEA)	Prediction Confidence Score 0.065 Applicability Domain 0.103 Low confidence Statistical Significance 0.9454 Supporting Reference Compounds 3 E-value 7360.25
Click to view 3D structure	Adenosine receptor A2b	P29275	Humans	Predicted (SEA)	Prediction Confidence Score 0.065 Applicability Domain 0.081 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 187 E-value 7784.38
Click to view 3D structure	Acetylcholinesterase	O42275	Electrophorus electricus	Predicted (SEA)	Prediction Confidence Score 0.064 Applicability Domain 0.073 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 206 E-value 7784.53
Click to view 3D structure	Cholinesterase	P81908	Equus caballus	Predicted (SEA)	Prediction Confidence Score 0.064 Applicability Domain 0.073 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 201 E-value 7784.53
Click to view 3D structure	Epidermal growth factor receptor	P00533	Humans	Predicted (SEA)	Prediction Confidence Score 0.064 Applicability Domain 0.067 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 1301 E-value 7784.69
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Predicted (SEA)	Prediction Confidence Score 0.064 Applicability Domain 0.075 Low confidence Statistical Significance 1.0 Supporting Reference Compounds 451 E-value 7784.61
Click to view 3D structure	Acetylcholinesterase	P37136	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.064 Applicability Domain 0.073 Low confidence Statistical Significance 0.9999 Supporting Reference Compounds 95 E-value 7784.14
Click to view 3D structure	Butyrylcholinesterase	Q9N1N9	Equus caballus	Predicted (SEA)	Prediction Confidence Score 0.063 Applicability Domain 0.067 Low confidence Statistical Significance 0.9998 Supporting Reference Compounds 44 E-value 7783.44
Click to view 3D structure	3-ketoacyl-CoA synthase 20	Q9FG87	Arabidopsis thaliana	Predicted (SEA)	Prediction Confidence Score 0.13 Applicability Domain 0.13 Low confidence Statistical Significance 0.0024 Supporting Reference Compounds 1 E-value 18.606
Click to view 3D structure	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	O67625	Aquifex aeolicus (strain VF5)	Predicted (SEA)	Prediction Confidence Score 0.111 Applicability Domain 0.111 Low confidence Statistical Significance 0.0058 Supporting Reference Compounds 1 E-value 45.0747
Click to view 3D structure	Cytochrome P450 4A4	P10611	Oryctolagus cuniculus	Predicted (SEA)	Prediction Confidence Score 0.1 Applicability Domain 0.1 Low confidence Statistical Significance 0.0615 Supporting Reference Compounds 1 E-value 478.695
Click to view 3D structure	Amine oxidase [flavin-containing] B	P27338	Humans	Predicted (SEA)	Prediction Confidence Score 0.097 Applicability Domain 0.111 Low confidence Statistical Significance 0.9996 Supporting Reference Compounds 315 E-value 7781.57
Click to view 3D structure	Epididymal secretory glutathione peroxidase	O75715	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Glutathione peroxidase 1	P07203	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Glutathione peroxidase 2	P18283	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Glutathione peroxidase 3	P22352	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Glutathione peroxidase 6	P59796	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Glutathione peroxidase 7	Q96SL4	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Phospholipid hydroperoxide glutathione peroxidase GPX4	P36969	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Probable glutathione peroxidase 8	Q8TED1	Humans	Known	The silver ion is known to inhibit glutathione peroxidase activity, disrupting selenium-catalyzed sulfhydryl oxidation-reduction reactions. (A246)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-1	P05023	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-2	P50993	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-3	P13637	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit alpha-4	Q13733	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-1	P05026	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-2	P14415	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit beta-3	P54709	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)
Click to view 3D structure	Sodium/potassium-transporting ATPase subunit gamma	P54710	Humans	Known	The silver ion is known to inhibit NA+,K+-ATPase activity, disrupting intracellular ion concentrations. (A243)

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Silver acetylide

Chemspider ID

Not Available

ChEBI ID

Not Available

PubChem Compound ID

Not Available

Kegg Compound ID

Not Available

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Bianchini A, Playle RC, Wood CM, Walsh PJ: Mechanism of acute silver toxicity in marine invertebrates. Aquat Toxicol. 2005 Mar 25;72(1-2):67-82. Epub 2004 Dec 29. [PubMed: 15748748]
AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S: Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano. 2009 Feb 24;3(2):279-90. doi: 10.1021/nn800596w. [PubMed: 19236062]
Kim S, Choi JE, Choi J, Chung KH, Park K, Yi J, Ryu DY: Oxidative stress-dependent toxicity of silver nanoparticles in human hepatoma cells. Toxicol In Vitro. 2009 Sep;23(6):1076-84. doi: 10.1016/j.tiv.2009.06.001. Epub 2009 Jun 7. [PubMed: 19508889]
Dillard CJ, Tappel AL: Mercury, silver, and gold inhibition of selenium-accelerated cysteine oxidation. J Inorg Biochem. 1986 Sep;28(1):13-20. [PubMed: 3760861]
ATSDR - Agency for Toxic Substances and Disease Registry (1990). Toxicological profile for silver. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). - http://www.atsdr.cdc.gov/toxprofiles/tp.asp?id=539&tid=97
Wikipedia. Silver. Last updated Dec 2014. - http://en.wikipedia.org/wiki/Silver
International Programme on Chemical Safety (IPCS) INCHEM (1977). WHO Food Additive Series No. 12: Silver. - http://www.inchem.org/documents/jecfa/jecmono/v12je19.htm

Silver acetylide (CED0009873)

Structure for CHEM001364: Silver acetylide

No pathways found

Structure