Fluvoxamine (CED0002849)

Record Information

Version

1.0

Creation Date

2009-07-21 20:26:13 UTC

Update Date

2026-05-14 16:24:29 UTC

SynCED ID

CED0002849

Secondary Accession Numbers

CHEM002137
T3D2705

Identification

Common Name

Fluvoxamine

Class

Small Molecule

Description

Fluvoxamine is an exogenous solid with the formula C15H21F3N2O2 and an average molecular weight of 318.33 g/mol. Fluvoxamine belongs to the trifluoromethylbenzenes, a subclass of benzene and substituted derivatives within the organic compounds. It is utilized as an antidepressant, an anxiolytic drug, and a biological serotonin uptake inhibitor. Recorded exposure routes for the compound include oral administration. It has been identified in seven recorded sources, including antidepressants within healthcare, pharmaceuticals, and veterinary products; drinking water and water supply; household cleaning and consumer products such as other smoking requisites and non-electric simulated smoking devices; and electrical and electronic equipment, specifically magnets, relays, and electric hearing aids. The compound interacts with eight recorded protein targets, including the sodium-dependent serotonin transporter (SLC6A4), 5-hydroxytryptamine receptor 1A (HTR1A), 5-hydroxytryptamine receptor 2A (HTR2A), muscarinic acetylcholine receptor M1 (CHRM1), cytochrome P450 2C9 (CYP2C9), sodium-dependent noradrenaline transporter (SLC6A2), and sodium-dependent dopamine transporter (SLC6A3). The antidepressant, antiobsessive-compulsive, and antibulimic actions of fluvoxamine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. It blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, which enhances the actions of serotonin on 5HT1A autoreceptors. Furthermore, SSRIs bind with significantly less affinity to norepinephrine, acetylcholine, and histamine receptors than tricyclic antidepressant drugs.

Contaminant Type

Amine
Anti-Anxiety Agent
Antidepressant
Antidepressant, Second-Generation
Antidepressive Agent, Second-Generation
Drug
Ether
Metabolite
Organic Compound
Organofluoride
Selective Serotonin Reuptake Inhibitor
Serotonin Uptake Inhibitor
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Fluvoxamina	ChEBI
Fluvoxaminum	ChEBI
Aliud brand OF fluvoxamine maleate	MeSH
Fluvoxamin neuraxpharm	MeSH
Geminis, fluvoxamina	MeSH
Ratiopharm brand OF fluvoxamine maleate	MeSH
Fluvoxamin stada	MeSH
Fluvoxamine	MeSH
Novopharm brand OF fluvoxamine maleate	MeSH
Nu fluvoxamine	MeSH
Stadapharm brand OF fluvoxamine maleate	MeSH
Neuraxpharm brand OF fluvoxamine maleate	MeSH
Faverin	MeSH
Fluvoxamin al	MeSH
Fluvoxamin ratiopharm	MeSH
Fluvoxamin-neuraxpharm	MeSH
Fluvoxamine, (Z)-isomer	MeSH
novo-Fluvoxamine	MeSH
Nu pharm brand OF fluvoxamine maleate	MeSH
Nu-fluvoxamine	MeSH
Declimed brand OF fluvoxamine maleate	MeSH
PMS Fluvoxamine	MeSH
Floxyfral	MeSH
Fluvoxamine maleate	MeSH
Pharmascience brand OF fluvoxamine maleate	MeSH
Desiflu	MeSH
Dumirox	MeSH
Fluvoxadura	MeSH
Fluvoxamin beta	MeSH
Fluvoxamin-ratiopharm	MeSH
Geminis brand OF fluvoxamine maleate	MeSH
Luvox	MeSH
Solvay brand OF fluvoxamine maleate	MeSH
Fevarin	MeSH
Fluvoxamina geminis	MeSH
Fluvoxamine maleate, (e)-isomer	MeSH
Merck dura brand OF fluvoxamine maleate	MeSH
Nu-pharm brand OF fluvoxamine maleate	MeSH
Betapharm brand OF fluvoxamine maleate	MeSH
novo Fluvoxamine	MeSH
PMS-Fluvoxamine	MeSH
ratio Fluvoxamine	MeSH
ratio-Fluvoxamine	MeSH

Chemical Formula

C₁₅H₂₁F₃N₂O₂

Average Molecular Mass

318.335 g/mol

Monoisotopic Mass

318.156 g/mol

CAS Registry Number

54739-18-3

IUPAC Name

(E)-(2-aminoethoxy)({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene})amine

Traditional Name

fluvoxamine

SMILES

COCCCC\C(=N/OCCN)C1=CC=C(C=C1)C(F)(F)F

InChI Identifier

InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+

InChI Key

InChIKey=CJOFXWAVKWHTFT-XSFVSMFZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as trifluoromethylbenzenes. These are organofluorine compounds that contain a benzene ring substituted with one or more trifluoromethyl groups.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Trifluoromethylbenzenes

Direct Parent

Trifluoromethylbenzenes

Alternative Parents

Substituents

Trifluoromethylbenzene
Dialkyl ether
Ether
Alkyl fluoride
Organopnictogen compound
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Organofluoride
Organohalogen compound
Primary aliphatic amine
Organic oxygen compound
Organic nitrogen compound
Amine
Alkyl halide
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

(trifluoromethyl)benzenes (CHEBI:5138 )
5-methoxyvalerophenone O-(2-aminoethyl)oxime (CHEBI:5138 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

serotonin uptake inhibitor ?
P450 inhibitor (PMC8362171 )?An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
inhibitor (PMC5402866 )?
Antidepressant (PMC9403794 , PMC10008739 )?
sigma-1 receptor agonist (PMC13237055 , PMC13237055 )?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	120-121.5°C
Boiling Point	Not Available
Solubility	7.34e-03 g/L

Predicted Properties

Property	Value	Source
Water Solubility	0.0073 g/L	ALOGPS
logP	2.89	ALOGPS
logP	2.8	ChemAxon
logS	-4.6	ALOGPS
pKa (Strongest Basic)	9.16	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	56.84 Å²	ChemAxon
Rotatable Bond Count	10	ChemAxon
Refractivity	79.2 m³·mol⁻¹	ChemAxon
Polarizability	32.44 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
544.0 Log mg/kg [310:970]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

The exact mechanism of action of fluvoxamine has not been fully determined, but appears to be linked to its inhibition of CNS neuronal uptake of serotonin. Fluvoxamine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. In-vitro studies suggest that fluvoxamine is more potent than clomipramine, fluoxetine, and desipramine as a serotonin-reuptake inhibitor. Studies have also demonstrated that fluvoxamine has virtually no affinity for alpha₁- or alpha₂-adrenergic, beta-adrenergic, muscarinic, dopamine D₂, histamine H₁, GABA-benzodiazepine, opiate, 5-HT₁, or 5-HT₂ receptors.

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

Side effects include anorexia, constipation, dry mouth, headache, nausea, nervousness, skin rash, sleep problems, somnolence, liver toxicity, mania, increase urination, seizures, sweating increase, tremors, or Tourette's syndrome.

Treatment

Treatment should consist of those general measures employed in the management of overdosage with any antidepressant. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. General supportive and symptomatic measures are also recommended. Induction of emesis is not recommended. Gastric lavage with a large-bore orogastric tube with appropriate airway protection, if needed, may be indicated if performed soon after ingestion, or in symptomatic patients. Activated charcoal should be administered. Due to the large volume of distribution of this drug, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit. No specific antidotes for fluvoxamine are known. (4)

Health Effects

Health Effect	Relationship	Direction	Description	Reference
major depressive disorder	Not Available	Not Available	An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. (DO)	PMC7806491
renal fibrosis	Has Therapeutic Effect On	Not Available	Not Available	PMC13237055 , PMC13237055
anxiety disorder	Not Available	Not Available	Not Available	PMC13237055
depressive disorder	Not Available	Not Available	Not Available	PMC13237055
obsessive-compulsive disorder	Not Available	Not Available	Not Available	PMC13237055

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000010	Insecticides?Insecticides are synthetic chemicals designed to control or eliminate insect pests that threaten crops and other agricultural products.	Agriculture & land management	PubChem
CEDs000115	Drinking water?Drinking water can be a medium for synthetic chemical contamination, often originating from various industrial processes and agricultural practices.	Drinking water & water supply	Not Available
CEDs000377	Antidepressants?Antidepressants, a class of synthetic chemicals designed to alleviate symptoms of depression and anxiety, can enter the environment through various pathways, leading to contamination of water systems.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000479	Effluent?Effluent refers to liquid waste or sewage that is discharged into the environment, typically resulting from industrial processes, municipal wastewater treatment, or agricultural runoff.	Wastewater, sanitation & biosolids	PMC11816319
CEDs000516	Electric Hearing Aids?Electric hearing aids are small electronic devices designed to amplify sound for individuals with hearing loss.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000527	Magnets?Magnets, commonly used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials used in their production.	Electrical & Electronic Equipment	PubChem
CEDs000530	Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.	Electrical & Electronic Equipment	PubChem
CEDs000531	Relays?Relays are electromechanical switches used to control circuits and manage electrical loads.	Electrical & Electronic Equipment	PubChem
CEDs000545	Food Preservation?Food preservation often involves the use of synthetic chemicals, such as preservatives, flavor enhancers, and color additives, to extend shelf life and enhance the sensory qualities of food products.	Food, food processing & cookware	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000560	Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000596	Acaricides?Acaricides are synthetic chemicals specifically designed to target and control mite populations that can damage crops and plants.	Agriculture & land management	PubChem
CEDs000600	Herbicides And Algicides?Herbicides and algicides are synthetic chemicals primarily used to control unwanted plants and algae in various environments.	Agriculture & land management	PubChem
CEDs000602	Molluscicides?Molluscicides are synthetic chemicals specifically designed to control and eliminate mollusks, such as snails and slugs, which can be detrimental to crops and agricultural productivity.	Agriculture & land management	PubChem
CEDs000603	Nematocides?Nematocides are synthetic chemicals specifically designed to control nematodes, which are microscopic roundworms that can cause significant damage to crops and plants.	Agriculture & land management	PubChem
CEDs000605	Pest Repellants?Pest repellents, often formulated from synthetic chemicals, are widely used to protect crops from insect infestations and other pests.	Agriculture & land management	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000698	Jewellery?Jewellery production often involves the use of various synthetic chemicals during the extraction and processing of metals.	Mining & metal processing	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000743	Sludge Treatment?Sludge treatment involves the processing of waste materials generated from wastewater treatment plants, which often contain a variety of organic and inorganic substances.	Wastewater, sanitation & biosolids	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem
CEDs01102	Pharmaceutical Preparations	Healthcare, pharmaceuticals & veterinary products	PMC7183319
CEDs02255	Water	Aquatic systems & sediments	PMC5306312
CEDs02257	Waters	Aquatic systems & sediments	PMC10114359
CEDs02268	Water Samples	Aquatic systems & sediments	PMC9403794

Pathways

2 pathwaysPathway Source: PathBank

Fluvoxamine Mechanism of Action Action Pathway New

Fluvoxamine Drug Metabolism Action Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Predicted (SEA)	Prediction Confidence Score 0.39 Applicability Domain 1.0 Statistical Significance 0.0341 Supporting Reference Compounds 1498 E-value 265.622
Click to view 3D structure	Cytochrome P450 2D6	P10635	Humans	Predicted (SEA)	Prediction Confidence Score 0.383 Applicability Domain 1.0 Statistical Significance 0.0182 Supporting Reference Compounds 1130 E-value 141.763
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Predicted (SEA)	Prediction Confidence Score 0.374 Applicability Domain 1.0 Statistical Significance 0.0088 Supporting Reference Compounds 506 E-value 68.1959
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q99720	Humans	Predicted (SEA)	Prediction Confidence Score 0.368 Applicability Domain 1.0 Statistical Significance 0.0198 Supporting Reference Compounds 562 E-value 154.375
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Predicted (SEA)	Prediction Confidence Score 0.368 Applicability Domain 1.0 Statistical Significance 0.0308 Supporting Reference Compounds 1245 E-value 240.009
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Predicted (SEA)	Prediction Confidence Score 0.365 Applicability Domain 1.0 Statistical Significance 0.0168 Supporting Reference Compounds 593 E-value 131.02
Click to view 3D structure	Sodium-dependent serotonin transporter	P31652	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.355 Applicability Domain 1.0 Statistical Significance 0.0117 Supporting Reference Compounds 297 E-value 91.3171
Click to view 3D structure	Sigma non-opioid intracellular receptor 1	Q9R0C9	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.349 Applicability Domain 1.0 Statistical Significance 0.0081 Supporting Reference Compounds 207 E-value 62.9022
Click to view 3D structure	Norepinephrine transporter	Q9WTR4	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.335 Applicability Domain 1.0 Statistical Significance 0.0058 Supporting Reference Compounds 112 E-value 45.5418
Click to view 3D structure	Sigma intracellular receptor 2	Q5U3Y7	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.334 Applicability Domain 1.0 Statistical Significance 0.0101 Supporting Reference Compounds 110 E-value 78.5499
Click to view 3D structure	Voltage-dependent L-type calcium channel subunit alpha-1C	O35505	Cavia porcellus	Predicted (SEA)	Prediction Confidence Score 0.323 Applicability Domain 1.0 Statistical Significance 3.10e-04 Supporting Reference Compounds 25 E-value 2.41333
Click to view 3D structure	Envelope phospholipase OPG057	P04021	Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strainWR))	Predicted (SEA)	Prediction Confidence Score 0.286 Applicability Domain 0.286 Low confidence Statistical Significance 0.002 Supporting Reference Compounds 1 E-value 15.8812
Click to view 3D structure	Voltage-gated potassium channel KCNC1	P25122	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.281 Applicability Domain 0.281 Low confidence Statistical Significance 5.00e-04 Supporting Reference Compounds 1 E-value 3.89246
Click to view 3D structure	Snake venom metalloproteinase neuwiedase	Q9I9R4	Bothrops pauloensis	Predicted (SEA)	Prediction Confidence Score 0.27 Applicability Domain 0.27 Low confidence Statistical Significance 0.0023 Supporting Reference Compounds 1 E-value 17.9053
Click to view 3D structure	Peroxisome proliferator-activated receptor gamma	P37231	Humans	Predicted (SEA)	Prediction Confidence Score 0.238 Applicability Domain 0.27 Low confidence Statistical Significance 0.1566 Supporting Reference Compounds 192 E-value 1219.43
Click to view 3D structure	Beta-2 adrenergic receptor	P18762	Mus musculus	Predicted (SEA)	Prediction Confidence Score 0.237 Applicability Domain 0.237 Low confidence Statistical Significance 0.0055 Supporting Reference Compounds 1 E-value 42.7392
Click to view 3D structure	Peroxisome proliferator-activated receptor alpha	Q07869	Humans	Predicted (SEA)	Prediction Confidence Score 0.233 Applicability Domain 0.27 Low confidence Statistical Significance 0.1405 Supporting Reference Compounds 127 E-value 1093.55
Click to view 3D structure	Thromboxane A2 receptor	P21731	Humans	Predicted (SEA)	Prediction Confidence Score 0.231 Applicability Domain 0.338 Statistical Significance 0.0858 Supporting Reference Compounds 96 E-value 667.713
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.23 Applicability Domain 0.255 Low confidence Statistical Significance 0.4988 Supporting Reference Compounds 955 E-value 3883.35
Click to view 3D structure	Amine oxidase [flavin-containing] B	P27338	Humans	Predicted (SEA)	Prediction Confidence Score 0.229 Applicability Domain 0.25 Low confidence Statistical Significance 0.2518 Supporting Reference Compounds 315 E-value 1960.4
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Predicted (SEA)	Prediction Confidence Score 0.227 Applicability Domain 0.237 Low confidence Statistical Significance 0.8006 Supporting Reference Compounds 1538 E-value 6232.45
Click to view 3D structure	Cytochrome P450 1A2	P05177	Humans	Predicted (SEA)	Prediction Confidence Score 0.227 Applicability Domain 0.237 Low confidence Statistical Significance 0.635 Supporting Reference Compounds 793 E-value 4943.74
Click to view 3D structure	Cytochrome P450 1A2	P05177	Humans	Known	Not Available
Click to view 3D structure	Peroxisome proliferator-activated receptor delta	Q03181	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.236 Low confidence Statistical Significance 0.1258 Supporting Reference Compounds 89 E-value 979.732
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.255 Low confidence Statistical Significance 0.5144 Supporting Reference Compounds 823 E-value 4004.33
Click to view 3D structure	Glucagon receptor	P47871	Humans	Predicted (SEA)	Prediction Confidence Score 0.226 Applicability Domain 0.244 Low confidence Statistical Significance 0.0655 Supporting Reference Compounds 46 E-value 509.679
Click to view 3D structure	Cytochrome P450 2C19	P33261	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 3A4	P08684	Humans	Known	Not Available
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Known	The antidepressant, antiobsessive-compulsive, and antibulimic actions of Fluvoxamine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Fluvoxamine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Known	The antidepressant, antiobsessive-compulsive, and antibulimic actions of Fluvoxamine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Fluvoxamine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Known	The antidepressant, antiobsessive-compulsive, and antibulimic actions of Fluvoxamine are presumed to be linked to its inhibition of CNS neuronal uptake of serotonin. Fluvoxamine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT_1A autoreceptors. SSRIs bind with significantly less affinity to histamine, acetylcholine, and norepinephrine receptors than tricyclic antidepressant drugs.
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Known	Not Available
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Known	Not Available
Click to view 3D structure	Cytochrome P450 2C9	P11712	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Known	Not Available
Click to view 3D structure	Voltage-gated inwardly rectifying potassium channel KCNH2	Q12809	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Fluvoxamine

Chemspider ID

Not Available

ChEBI ID

5138

PubChem Compound ID

5324346

Kegg Compound ID

C07571

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Welle, H.B.A. and Claassen, V.; U.S. Patent 4,085,225; April 18, 1978; assigned to U.S. Phillips Corp.

MSDS

Link

General References

Dell'Osso B, Allen A, Hollander E: Fluvoxamine: a selective serotonin re-uptake inhibitor for the treatment of obsessive-compulsive disorder. Expert Opin Pharmacother. 2005 Dec;6(15):2727-40. [PubMed: 16316311]
Irons J: Fluvoxamine in the treatment of anxiety disorders. Neuropsychiatr Dis Treat. 2005 Dec;1(4):289-99. [PubMed: 18568110]
Drugs.com - http://www.drugs.com/cons/Fluvoxamine.html
RxList: The Internet Drug Index (2009). - http://www.rxlist.com/

Fluvoxamine (CED0002849)

Structure for CHEM002137: Fluvoxamine

Structure