Benzatropine (CED0005224)

Benzatropine is an exogenous compound with the formula C21H25NO and an average molecular weight of 307.43 g/mol. It exists as a solid at room temperature. Benzatropine belongs to the diphenylmethanes, a subclass of benzene and substituted derivatives within the organic compounds. The compound is used as an antiparkinson drug, an antidyskinesia agent, a parasympatholytic, and a muscarinic antagonist. It is recorded as being found in healthcare, pharmaceuticals, and veterinary products as an anticholinergic agent. Other recorded sources include food preservation, electrical and electronic equipment such as electrically stimulated smoking devices, and household cleaning and consumer products, including perfumes within detergents and soaps, tobacco smoke filters, and cigar cigarettes. Exposure routes include oral, intravenous, intramuscular, and parenteral administration. Benzatropine acts on five recorded protein targets. It is a selective M1 muscarinic acetylcholine receptor (CHRM1) antagonist that can discriminate between the peripheral muscarinic subtypes and the neuronal or cortical M1 receptor. By partially blocking cholinergic activity in the CNS, it addresses symptoms of Parkinson's disease. Additionally, it is thought to increase the availability of dopamine, which is critical for the smooth control and initiation of voluntary muscle movement. Benzatropine also targets the sodium-dependent dopamine transporter (SLC6A3), the sodium-dependent serotonin transporter (SLC6A4), the sodium-dependent noradrenaline transporter (SLC6A2), and acts as an inhibitor of the histamine H1 receptor (HRH1).