Loxapine (CED0006987)

Record Information

Version

1.0

Creation Date

2009-07-21 20:26:49 UTC

Update Date

2026-05-14 16:37:50 UTC

SynCED ID

CED0006987

Secondary Accession Numbers

CHEM002188
T3D2779

Identification

Common Name

Loxapine

Class

Small Molecule

Description

Loxapine is an exogenous organic compound with the formula C18H18ClN3O and an average molecular weight of 327.81 g/mol. It exists as a solid at room temperature. Loxapine belongs to the dibenzoxazepines, a subclass of benzoxazepines within the organic compounds. This compound is used as an antipsychotic agent and functions as a dopaminergic antagonist. It targets 32 recorded proteins, including the D(1A) dopamine receptor (DRD1), D(2) dopamine receptor (DRD2), 5-hydroxytryptamine receptor 2A (HTR2A), 5-hydroxytryptamine receptor 2C (HTR2C), 5-hydroxytryptamine receptor 1A (HTR1A), 5-hydroxytryptamine receptor 1B (HTR1B), and 26 other proteins. Loxapine is a dopamine antagonist and a serotonin 5-HT2 blocker. While its exact mode of action has not been established, changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with tranquilization manifestations, such as calming effects and the suppression of aggressive behavior. Loxapine is found in 11 recorded sources. Within healthcare, pharmaceuticals, and veterinary products, it is found in antipsychotics. It is also recorded in electrical and electronic equipment, including antennas, electrodes, radio transmission systems, and electrically stimulated smoking devices. Additionally, it appears in household cleaning and consumer products, such as perfumes within detergents and soaps, cigar cigarettes, non-electric simulated smoking devices, pipe accessories, and other smoking requisites. Recorded exposure routes for the compound include oral, intramuscular, and respiratory administration.

Contaminant Type

Amine
Antipsychotic Agent
Dopamine Antagonist
Drug
Ether
Metabolite
Organic Compound
Organochloride
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz[b,F][1,4]oxazepine	ChEBI
Cloxazepine	ChEBI
Loxapina	ChEBI
Loxapinum	ChEBI
Oxilapine	ChEBI
Adasuve	Kegg
Loxapine hydrochloride	HMDB
Loxapine succinate	HMDB
Loxipine maleate	HMDB
Loxapine monohydrochloride	HMDB
Loxapinsuccinate	HMDB
Succinate, loxapine	HMDB
Hydrochloride, loxapine	HMDB
Loxipine succinate	HMDB
Loxitane	HMDB
2-Chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,F)(1,4)oxazepine	HMDB
Maleate, loxipine	HMDB

Chemical Formula

C₁₈H₁₈ClN₃O

Average Molecular Mass

327.808 g/mol

Monoisotopic Mass

327.114 g/mol

CAS Registry Number

1977-10-2

IUPAC Name

13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3,5,7,9,12,14-heptaene

Traditional Name

loxapine

SMILES

CN1CCN(CC1)C1=NC2=CC=CC=C2OC2=C1C=C(Cl)C=C2

InChI Identifier

InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

InChI Key

XJGVXQDUIWGIRW-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as dibenzoxazepines. Dibenzoxazepines are compounds containing a dibenzoxazepine moiety, which consists of two benzene connected by an oxazepine ring.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzoxazepines

Sub Class

Dibenzoxazepines

Direct Parent

Dibenzoxazepines

Alternative Parents

Substituents

Dibenzoxazepine
Diaryl ether
N-methylpiperazine
N-alkylpiperazine
Aryl chloride
Aryl halide
1,4-diazinane
Piperazine
Benzenoid
Imidolactam
Tertiary amine
Tertiary aliphatic amine
Oxacycle
Azacycle
Carboxylic acid amidine
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Ether
Amidine
Amine
Organic oxygen compound
Organohalogen compound
Organochloride
Organonitrogen compound
Organooxygen compound
Organic nitrogen compound
Hydrocarbon derivative
Organopnictogen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

dibenzoxazepine (CHEBI:50841 )

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Membrane

Biofluid Locations

Not Available

Tissue Locations

Not Available

Applications

Biological Roles

dopaminergic antagonist ?

Chemical Roles

Not Available

Organoleptic Effects

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	109-111°C
Boiling Point	Not Available
Solubility	1.03e-01 g/L

Predicted Properties

Property	Value	Source
Water Solubility	0.1 g/L	ALOGPS
logP	3.18	ALOGPS
logP	3.46	ChemAxon
logS	-3.5	ALOGPS
pKa (Strongest Basic)	7.18	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	28.07 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	95.11 m³·mol⁻¹	ChemAxon
Polarizability	34.99 Å³	ChemAxon
Number of Rings	4	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum	splash10-06r5-8094000000-3f11548f145e2cd0d2a5	Not Available	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum	Not Available	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00ai-0149000000-d463f8ddf4248264d132	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-01r6-0930000000-4798aec046d747300d80	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00ai-0149000000-d463f8ddf4248264d132	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-01r6-0930000000-4798aec046d747300d80	Not Available	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum	splash10-00di-0092000000-d36334adec23dfc827b7	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0009000000-13c7c5980fa375485ea6	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0029000000-ee11b761132aadb447f8	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-0596-9250000000-cdb8e78cf5fd1fd059b9	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0009000000-71d4c9395b89ad9fc22a	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0039000000-ca6576c997e0e1af0ab2	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-006y-3491000000-40caba03e0caacbf4b76	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0009000000-1f57d14978e5410155ca	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0019000000-171a44896a8b8aa67151	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-00di-0090000000-8f9b474f4d539ce49d69	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0009000000-f859e2aff8bfc6f7a27b	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-004i-0039000000-568c941d47f67e7c6c41	Not Available	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum	splash10-001i-5091000000-1f13f155778e72cff118	Not Available	View Spectrum
MS	MS Spectrum	splash10-0a4l-7590000000-118f30ca0699bf2b3d2e	Not Available	View Spectrum

Toxicity Profile

Toxicity Values

Toxicity Value	Organism	Dose Descriptor	Route of Exposure	Predicted or Experimental	Toxicity Rating	Reference
288.0 Log mg/kg [160:510]	Rat	LD50	oral	predicted	Not Available	Not Available

Toxicity / Toxin Class

Not Available

Mechanism of Toxicity

Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior. LD₅₀=65 mg/kg (Orally in mice)

Carcinogenicity (IARC Classification)

No indication of carcinogenicity to humans (not listed by IARC).

Minimum Risk Level

Not Available

Symptoms

LD₅₀=65 mg/kg (Orally in mice)

Treatment

The treatment of overdosage is essentially symptomatic and supportive. Early gastric lavage and extended dialysis might be expected to be beneficial. Centrally-acting emetics may have little effect because of the antiemetic action of loxapine. In addition, emesis should be avoided because of the possibility of aspiration of vomitus. Avoid analeptics, such as pentylenetetrazol, which may cause convulsions. Severe hypotension might be expected to respond to the administration of levarterenol or phenylephrine. Epinephrine should not be used since its use in a patient with partial adrenergic blockade may further lower the blood pressure. Severe extrapyramidal reactions should be treated with anticholinergic antiparkinson agents or diphenhydramine hydrochloride, and anticonvulsant therapy should be initiated as indicated. Additional measures include oxygen and intravenous fluids. (4)

Health Effects

Health Effect	Relationship	Direction	Description	Reference

Exposure Sources

Source ID	Source	Sector	Reference
CEDs000374	Antipsychotics?Antipsychotics are a class of synthetic chemicals used primarily for the treatment of psychiatric disorders, including schizophrenia and bipolar disorder.	Healthcare, pharmaceuticals & veterinary products	Not Available
CEDs000506	Antennas?Antennas, commonly used in communication technologies, can be a source of synthetic chemical contamination through the materials and coatings used in their construction.	Electrical & Electronic Equipment	PubChem
CEDs000518	Electrically Stimulated Smoking Devices?Electrically stimulated smoking devices, commonly known as e-cigarettes or vape pens, utilize electrical components to heat a liquid solution, often containing nicotine, flavorings, and other additives, to produce an aerosol for inhalation.	Electrical & Electronic Equipment	PubChem
CEDs000519	Electrodes?Electrodes, used in various electrical and electronic applications, can be a source of synthetic chemical contamination due to the materials from which they are constructed and the processes involved in their manufacturing.	Electrical & Electronic Equipment	PubChem
CEDs000530	Radio Transmission Systems?Radio transmission systems utilize a variety of synthetic chemicals in their manufacturing and maintenance processes.	Electrical & Electronic Equipment	PubChem
CEDs000556	Cigar Cigarettes?Cigar cigarettes are a source of synthetic chemical contamination due to the combustion of various tobacco blends and additives.	Household cleaning & consumer products	PubChem
CEDs000559	Non Electric Simulated Smoking Devices?Non-electric simulated smoking devices, often designed to mimic the experience of smoking without combustion, can be sources of synthetic chemical contamination due to the materials and chemicals used in their construction and operation.	Household cleaning & consumer products	PubChem
CEDs000560	Other Smoking Requisites?Other smoking requisites, including items such as lighters, matches, and rolling papers, can introduce synthetic chemical contamination through various components and additives.	Household cleaning & consumer products	PubChem
CEDs000561	Perfumes Within Detergents And Soaps?Perfumes within detergents and soaps are synthetic fragrance compounds added to enhance the sensory experience of cleaning products.	Household cleaning & consumer products	PubChem
CEDs000562	Pipe Accessories?Pipe accessories, such as fittings, connectors, and seals, are components used in plumbing systems to facilitate the flow of liquids and gases.	Household cleaning & consumer products	PubChem
CEDs000569	Tobacco Smoke Filters?Tobacco smoke filters are designed to reduce the inhalation of harmful substances in cigarette smoke, including tar and other particulate matter.	Household cleaning & consumer products	PubChem
CEDs000580	Manufacture Preparation Of Tobacco Products?The manufacture and preparation of tobacco products involve various processes that can result in the introduction of synthetic chemicals into the environment.	Industrial manufacturing & chemical processing	PubChem
CEDs000611	Anti Perspirants Or Body Deoderants?Antiperspirants and body deodorants commonly contain synthetic chemicals such as aluminum compounds, parabens, and synthetic fragrances.	Personal care & cosmetics	PubChem
CEDs000613	Depilatories?Depilatories are products designed to remove unwanted hair through the application of synthetic chemicals that break down the protein structure of hair, facilitating its removal.	Personal care & cosmetics	PubChem
CEDs000614	Essential Oils Or Perfumes?Essential oils and perfumes are complex mixtures of volatile compounds derived from natural or synthetic sources, commonly used for their aromatic properties.	Personal care & cosmetics	PubChem
CEDs000615	Eye Makeup Products?Eye makeup products, including mascaras, eyeliners, and eyeshadows, often contain a variety of synthetic chemicals such as pigments, preservatives, and film-forming agents.	Personal care & cosmetics	PubChem
CEDs000618	Lip Makeup Products?Lip makeup products, such as lipsticks, lip glosses, and lip liners, often contain a variety of synthetic chemicals, including pigments, preservatives, and emollients.	Personal care & cosmetics	PubChem
CEDs000632	Apparel?Apparel production often involves the use of various synthetic chemicals, including dyes, finishing agents, and preservatives.	Textiles, leather & furnishings	PubChem
CEDs000642	Footwear?Footwear production often involves the use of various synthetic chemicals, such as adhesives, dyes, and treatments, which can contribute to environmental contamination.	Textiles, leather & furnishings	PubChem
CEDs000650	Purses Luggage Hand Bags?Purses, luggage, and handbags are often manufactured using synthetic materials such as polyvinyl chloride (PVC), polyurethane, and various types of nylon.	Textiles, leather & furnishings	PubChem
CEDs000651	Purses Money Bags Wallets?Purses, money bags, and wallets are often manufactured using synthetic materials, including plastics, polyurethanes, and various treated fabrics.	Textiles, leather & furnishings	PubChem
CEDs000671	Airplanes And Helicopters?Airplanes and helicopters are significant sources of synthetic chemical contamination primarily through the use of aviation fuels, lubricants, and de-icing agents.	Aviation & Aerospace	PubChem
CEDs000685	Ceramics?Ceramics can be a source of synthetic chemical contamination through various additives and processing agents used in their production.	Building & Construction	PubChem
CEDs000696	Nanotechnology?Nanotechnology involves the manipulation of materials at the molecular or atomic level, typically within the range of 1 to 100 nanometers.	Industrial manufacturing & chemical processing	PubChem
CEDs000735	Explosives?Explosives are chemical compounds or mixtures designed to undergo rapid decomposition, releasing energy in the form of gas and heat.	Defense & military infrastructure	PubChem
CEDs000739	Inks?Inks are complex mixtures composed of pigments or dyes, solvents, resins, and additives used primarily for printing and writing applications.	Paper, pulp & fiber products	PubChem
CEDs000744	Water, Wastewater, & Sewage Treatment?Water, wastewater, and sewage treatment processes are critical for managing and mitigating pollutants in water systems.	Wastewater, sanitation & biosolids	PubChem

Pathways

3 pathwaysPathway Source: PathBank

Loxapine Dopamine Antagonist Action Pathway

Loxapine Drug Metabolism Action Pathway

Loxapine Predicted Metabolism Pathway

Targets

Structure	Protein	UniProt ID	Organism	Relationship	Details
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Predicted (SEA)	Prediction Confidence Score 0.765 Applicability Domain 1.0 Statistical Significance 1.90e-04 Supporting Reference Compounds 1103 E-value 1.47914
Click to view 3D structure	D(4) dopamine receptor	P21917	Humans	Predicted (SEA)	Prediction Confidence Score 0.765 Applicability Domain 1.0 Statistical Significance 5.00e-05 Supporting Reference Compounds 524 E-value 0.389246
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P14842	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.728 Applicability Domain 1.0 Statistical Significance 1.50e-04 Supporting Reference Compounds 380 E-value 1.16774
Click to view 3D structure	Histamine H4 receptor	Q9H3N8	Humans	Predicted (SEA)	Prediction Confidence Score 0.709 Applicability Domain 1.0 Statistical Significance 3.00e-05 Supporting Reference Compounds 150 E-value 0.233548
Click to view 3D structure	D(2) dopamine receptor	P61169	Rat	Predicted (SEA)	Prediction Confidence Score 0.696 Applicability Domain 1.0 Statistical Significance 4.50e-04 Supporting Reference Compounds 528 E-value 3.50322
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P08909	Rat	Predicted (SEA)	Prediction Confidence Score 0.684 Applicability Domain 1.0 Statistical Significance 1.40e-04 Supporting Reference Compounds 185 E-value 1.08989
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Predicted (SEA)	Prediction Confidence Score 0.68 Applicability Domain 1.0 Statistical Significance 8.00e-04 Supporting Reference Compounds 861 E-value 6.22794
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Predicted (SEA)	Prediction Confidence Score 0.656 Applicability Domain 1.0 Statistical Significance 4.60e-04 Supporting Reference Compounds 955 E-value 3.58106
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Predicted (SEA)	Prediction Confidence Score 0.637 Applicability Domain 1.0 Statistical Significance 2.80e-04 Supporting Reference Compounds 536 E-value 2.17978
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Predicted (SEA)	Prediction Confidence Score 0.633 Applicability Domain 1.0 Statistical Significance 2.90e-04 Supporting Reference Compounds 385 E-value 2.25763
Click to view 3D structure	Histamine H1 receptor	P31390	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.549 Applicability Domain 1.0 Statistical Significance 1.30e-04 Supporting Reference Compounds 63 E-value 1.01204
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Predicted (SEA)	Prediction Confidence Score 0.542 Applicability Domain 0.739 Statistical Significance 8.90e-04 Supporting Reference Compounds 487 E-value 6.92858
Click to view 3D structure	D(1A) dopamine receptor	P21728	Humans	Predicted (SEA)	Prediction Confidence Score 0.53 Applicability Domain 0.739 Statistical Significance 0.0018 Supporting Reference Compounds 425 E-value 13.7793
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Predicted (SEA)	Prediction Confidence Score 0.529 Applicability Domain 0.739 Statistical Significance 0.0047 Supporting Reference Compounds 953 E-value 36.3556
Click to view 3D structure	D(1A) dopamine receptor	P18901	Rattus norvegicus	Predicted (SEA)	Prediction Confidence Score 0.506 Applicability Domain 0.558 Statistical Significance 0.0015 Supporting Reference Compounds 206 E-value 11.5217
Click to view 3D structure	Histamine H1 receptor	P35367	Humans	Predicted (SEA)	Prediction Confidence Score 0.504 Applicability Domain 0.739 Statistical Significance 0.0019 Supporting Reference Compounds 507 E-value 14.8692
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Predicted (SEA)	Prediction Confidence Score 0.504 Applicability Domain 0.739 Statistical Significance 0.0033 Supporting Reference Compounds 823 E-value 25.3788
Click to view 3D structure	5-hydroxytryptamine receptor 2B	P41595	Humans	Predicted (SEA)	Prediction Confidence Score 0.504 Applicability Domain 0.739 Statistical Significance 0.0021 Supporting Reference Compounds 686 E-value 16.7376
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Predicted (SEA)	Prediction Confidence Score 0.493 Applicability Domain 0.739 Statistical Significance 4.00e-04 Supporting Reference Compounds 266 E-value 3.11397
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Predicted (SEA)	Prediction Confidence Score 0.493 Applicability Domain 0.739 Statistical Significance 6.10e-04 Supporting Reference Compounds 373 E-value 4.7488
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Predicted (SEA)	Prediction Confidence Score 0.493 Applicability Domain 0.739 Statistical Significance 7.40e-04 Supporting Reference Compounds 310 E-value 5.76084
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Predicted (SEA)	Prediction Confidence Score 0.493 Applicability Domain 0.739 Statistical Significance 6.30e-04 Supporting Reference Compounds 297 E-value 4.9045
Click to view 3D structure	Alpha-2B adrenergic receptor	P18089	Humans	Predicted (SEA)	Prediction Confidence Score 0.479 Applicability Domain 0.739 Statistical Significance 0.0012 Supporting Reference Compounds 340 E-value 9.10836
Click to view 3D structure	Alpha-2C adrenergic receptor	P18825	Humans	Predicted (SEA)	Prediction Confidence Score 0.479 Applicability Domain 0.739 Statistical Significance 0.0014 Supporting Reference Compounds 386 E-value 10.5875
Click to view 3D structure	5-hydroxytryptamine receptor 7	P34969	Humans	Predicted (SEA)	Prediction Confidence Score 0.475 Applicability Domain 0.739 Statistical Significance 0.0044 Supporting Reference Compounds 565 E-value 34.6429
Click to view 3D structure	D(2) dopamine receptor	P14416	Humans	Known	Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
Click to view 3D structure	D(4) dopamine receptor	P21917	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 2A	P28223	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 6	P50406	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M2	P08172	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 2C	P28335	Humans	Known	Not Available
Click to view 3D structure	Alpha-2A adrenergic receptor	P08913	Humans	Known	Not Available
Click to view 3D structure	D(1A) dopamine receptor	P21728	Humans	Known	Loxapine is a dopamine antagonist, and also a serotonin 5-HT2 blocker. The exact mode of action of Loxapine has not been established, however changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such manifestations of tranquilization as calming effects and suppression of aggressive behavior.
Click to view 3D structure	D(3) dopamine receptor	P35462	Humans	Known	Not Available
Click to view 3D structure	Histamine H1 receptor	P35367	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M1	P11229	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M3	P20309	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M4	P08173	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 1A	P08908	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 1B	P28222	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 1D	P28221	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 1E	P28566	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 3A	P46098	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 5A	P47898	Humans	Known	Not Available
Click to view 3D structure	5-hydroxytryptamine receptor 7	P34969	Humans	Known	Not Available
Click to view 3D structure	Alpha-1A adrenergic receptor	P35348	Humans	Known	Not Available
Click to view 3D structure	Alpha-1B adrenergic receptor	P35368	Humans	Known	Not Available
Click to view 3D structure	Alpha-2B adrenergic receptor	P18089	Humans	Known	Not Available
Click to view 3D structure	Alpha-2C adrenergic receptor	P18825	Humans	Known	Not Available
Click to view 3D structure	Beta-1 adrenergic receptor	P08588	Humans	Known	Not Available
Click to view 3D structure	D(1B) dopamine receptor	P21918	Humans	Known	Not Available
Click to view 3D structure	Histamine H2 receptor	P25021	Humans	Known	Not Available
Click to view 3D structure	Histamine H4 receptor	Q9H3N8	Humans	Known	Not Available
Click to view 3D structure	Muscarinic acetylcholine receptor M5	P08912	Humans	Known	Not Available
Click to view 3D structure	Sodium-dependent dopamine transporter	Q01959	Humans	Known	Not Available
Click to view 3D structure	Sodium-dependent noradrenaline transporter	P23975	Humans	Known	Not Available
Click to view 3D structure	Sodium-dependent serotonin transporter	P31645	Humans	Known	Not Available

Concentrations

Not Available

External Links

DrugBank ID

DB00408

HMDB ID

HMDB0014552

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Chemspider ID

ChEBI ID

PubChem Compound ID

Kegg Compound ID

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

U.S. Patents 3,412,193; 3,546,226.

MSDS

Not Available

General References

Glazer WM: Does loxapine have "atypical" properties? Clinical evidence. J Clin Psychiatry. 1999;60 Suppl 10:42-6. [PubMed: 10340686]
Cheung SW, Tang SW, Remington G: Simultaneous quantitation of loxapine, amoxapine and their 7- and 8-hydroxy metabolites in plasma by high-performance liquid chromatography. J Chromatogr. 1991 Mar 8;564(1):213-21. [PubMed: 1860915]
Drugs.com - http://www.drugs.com/cons/Loxapine.html
RxList: The Internet Drug Index (2009). - http://www.rxlist.com/

Loxapine (CED0006987)

Structure for CHEM002188: Loxapine

Structure